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Search: authors:"Nana Fukuda"

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HHEX is a transcriptional regulator of the VEGFC/FLT4/PROX1 signaling axis during vascular development

Formation of the lymphatic system requires the coordinated expression of several key regulators: vascular endothelial growth factor C (VEGFC), its receptor FLT4, and a key transcriptional effector, PROX1. Yet, how expression of these signaling components is regulated remains poorly understood. Here, using a combination of genetic and molecular approaches, we identify the...

Evolutionary Transitions of MicroRNA-Target Pairs

How newly generated microRNA (miRNA) genes are integrated into gene regulatory networks during evolution is fundamental in understanding the molecular and evolutionary bases of robustness and plasticity in gene regulation. A recent model proposed that after the birth of a miRNA, the miRNA is generally integrated into the network by decreasing the number of target genes during...

Tissue- and Stage-Dependent Dosage Compensation on the Neo-X Chromosome in Drosophila pseudoobscura

Sex chromosome dosage compensation (DC) is widely accepted in various organisms. This concept is mostly supported by comparisons of gene expression between chromosomes and between sexes. However, genes on the X chromosome and autosomes are mostly not homologous, and the average gene expression level on these chromosomes may not be the same even under DC, which complicates...

No association between Helicobacter pylori infection and diabetes mellitus among a general Japanese population: a cross-sectional study

Kawai Tae Sasakabe Yuka Sugimoto Nana Fukuda Shino Suma Hiroko Nakagawa Rieko Okada Asahi Hishida Mariko Naito Nobuyuki Hamajima Kenji Wakai 0 Department of Epidemiology and Preventive Medicine, Gifu