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Search: authors:"Naotaka Tsutsumi"

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An innate interaction between IL-18 and the propeptide that inactivates its precursor form

Uncontrolled secretion of mature interleukin (IL)-1β and IL-18 is responsible for severe autoinflammatory or autoimmune disorders and various allergic diseases. Here we report an intramolecular interaction between IL-18 and its propeptide, which is proteolytically removed from its precursor proIL-18 during maturation. The intramolecular interaction was recapitulated...

The structural basis for receptor recognition of human interleukin-18

, Gifu University, Gifu 501-1194, JapanZenichiro Kato AuthorsSearch for Naotaka Tsutsumi in:Nature Research journals • PubMed • Google ScholarSearch for Takeshi Kimura in:Nature Research journals • PubMed