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mRNAs containing NMD-competent premature termination codons are stabilized and translated under UPF1 depletion

for Nara Shin in:Nature Research journals • PubMed • Google Scholar Search for Jiyoon Kim in:Nature Research journals • PubMed • Google Scholar Search for Hoguen Kim in:Nature Research journals

Effect of post-transplant glycemic control on long-term clinical outcomes in kidney transplant recipients with diabetic nephropathy: A multicenter cohort study in Korea

. Supporting information S1 File. Individual patient information. (XLSX) Author Contributions Conceptualization: Yong Chul Kim, Nara Shin, Young Hoon Kim, Hyosang Kim, Jang-Hee Cho, Chan-Duck Kim, Dong-Wan ... Chae, Jung Pyo Lee. Data curation: Nara Shin, Young Hoon Kim, Jang-Hee Cho, Chan-Duck Kim, Jongwon Ha. Formal analysis: Yong Chul Kim, Nara Shin, Sunhwa Lee, Jung Pyo Lee, Yon Su Kim. Methodology

Primary cilia modulate TLR4-mediated inflammatory responses in hippocampal neurons

The primary cilium is an organelle that can act as a master regulator of cellular signaling. Despite the presence of primary cilia in hippocampal neurons, their function is not fully understood. Recent studies have demonstrated that the primary cilium influences interleukin (IL)-1β-induced NF-κB signaling, ultimately mediating the inflammatory response. We, therefore...

CR6 interacting factor 1 deficiency promotes endothelial inflammation by SIRT1 downregulation

group). (TIF) Acknowledgments dQikwW Author Contributions Conceptualization: Jun Wan Lee. hee Kim, Nara Shin, Cuk-Seong Kim. Funding acquisition: Cuk-Seong Kim. Data curation: Shuyu Piao, Jun Wan

CD200R/Foxp3-mediated signalling regulates microglial activation

The heterogeneity of microglial functions have either beneficial or detrimental roles in specific physiological or pathological environments. However, the details of what transcriptional mechanisms induce microglia to take beneficial phenotypes remain unknown. Here, we report that Foxp3 is essential for beneficial outcome of the microglial response and depends upon signalling by...

Endoplasmic reticulum stress impairment in the spinal dorsal horn of a neuropathic pain model

National University School of Medicine, Daejeon 301-747, South KoreaEnji Zhang, Min-Hee Yi, Nara Shin, Hyunjung Baek, Sena Kim, Eunjee Kim, Kisang Kwon, O.-Yu Kwon & Dong Woon KimDepartment of Anesthesia and ... Zhang in:Nature Research journals • PubMed • Google ScholarSearch for Min-Hee Yi in:Nature Research journals • PubMed • Google ScholarSearch for Nara Shin in:Nature Research journals • PubMed • Google

Diagnostic Significance of Serum HMGB1 in Colorectal Carcinomas

High mobility group box 1 protein (HMGB1), a nuclear protein, can be translocated to the cytoplasm and secreted in colon cancer cells. However, the diagnostic significance of HMGB1 has not been evaluated in colorectal carcinomas. For this purpose, we have screened the expression and secretion of HMGB1 in 10 colon cancer cell lines and 1 control cell line and found that HMGB1 was...

Cinacalcet lowering of serum fibroblast growth factor-23 concentration may be independent from serum Ca, P, PTH and dose of active vitamin D in peritoneal dialysis patients: a randomized controlled study

Background Elevated serum level of fibroblast growth factor-23 (FGF23) is associated with adverse outcomes in dialyzed patients. Objectives The CUPID study compared the efficacy of a cinacalcet-based regimen with conventional care (vitamin D and P binders) for achieving the stringent NKF-K/DOQI targets for peritoneal dialysis (PD) patients. Additionally, we analyzed change in...