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Stem cell-secreted 14,15- epoxyeicosatrienoic acid rescues cholesterol homeostasis and autophagic flux in Niemann–Pick-type C disease

Kang, Byung-Chul Lee, Jin Young Lee, Jae-Jun Kim, Eun-Ah Sung, Seung Eun Lee, Nari Shin, Soon Won Choi & Kyung-Sun KangBK21 PLUS Program for Creative Veterinary Science Research and Research Institute ... for Veterinary Science, College of Veterinary Medicine, Seoul National University, Seoul, 08826, South KoreaInsung Kang, Byung-Chul Lee, Jin Young Lee, Jae-Jun Kim, Eun-Ah Sung, Seung Eun Lee, Nari Shin

Donor-dependent variation of human umbilical cord blood mesenchymal stem cells in response to hypoxic preconditioning and amelioration of limb ischemia

With the rapidly growing demand for mesenchymal stem cell (MSC) therapy, numerous strategies using MSCs for different diseases have been studied and reported. Because of their immunosuppressive properties, MSCs are commonly used as an allogeneic treatment. However, for the many donors who could potentially be used, it is important to understand the capacity for therapeutic usage...

Enhanced expression of two discrete isoforms of matrix metalloproteinase-2 in experimental and human diabetic nephropathy

Background We recently reported on the enhanced expression of two isoforms of matrix metalloproteinase-2 (MMP-2) in human renal transplantation delayed graft function. These consist of the conventional secreted, full length MMP-2 isoform (FL-MMP-2) and a novel intracellular N-Terminal Truncated isoform (NTT-MMP-2) generated by oxidative stress-mediated activation of an alternate...