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Gut microbiota and butyrate level changes associated with the long-term administration of proton pump inhibitors to old rats

The association between adverse effects of PPI and gut microbiota in old age has yet to be elucidated. We assessed changes in the gut microbiota and butyrate levels following the long-term administration of PPIs to old rats and investigated their associations. F344 aged male rats were fed a PPI-supplemented diet for 50 weeks. The ileal microbiota was analysed by metagenomic...

Correlation between macrophage migration inhibitory factor and autophagy in Helicobacter pylori-associated gastric carcinogenesis

. pylori-associated gastric carcinogenesis. - Data Availability Statement: All relevant data are within the manuscript and its Supporting Information files. Funding: Nayoung Kim - This work was supported ... obtained from the antrum and the mid-body of the stomach, respectively [ 17 ], performed solely by Nayoung Kim. Tissue sections were stained with hematoxylin and eosin (H&E) stain for histological

Trends in emergency department visits and hospitalization rates for inflammatory bowel disease in the era of biologics

: Hyuk Yoon. Resources: Yoon Jin Choi, Cheol Min Shin, Young Soo Park. Supervision: Hyuk Yoon, Nayoung Kim, Dong Ho Lee, Joo Sung Kim. Writing ? original draft: Gunn Huh. Writing ? review & editing: Hyuk

Is nonalcoholic fatty liver disease associated with the development of prostate cancer? A nationwide study with 10,516,985 Korean men

. Funding acquisition: Dong Ho Lee. Supervision: Dong Ho Lee, Nayoung Kim. Writing ? original draft: Yoon Jin Choi, Young Soo Park. Writing ? review & editing: Hyuk Yoon, Cheol Min Shin. 11 / 13 12 / 13 1

Correction: The relationship between drinking alcohol and esophageal, gastric or colorectal cancer: A nationwide population-based cohort study of South Korea

Han Hyun Soo Kim Hyuk Yoon Cheol Min Shin Young Soo Park Nayoung Kim There is an error in Tables 2 and 3. The values ?Mild to moderate? in the footnote "a" in the legends of Tables 2 and 3 are defined

Trends in the seroprevalence of Helicobacter pylori infection and its putative eradication rate over 18 years in Korea: A cross-sectional nationwide multicenter study

Contributions Conceptualization: Seon Hee Lim, Nayoung Kim. Data curation: Seon Hee Lim, Nayoung Kim, Sung Eun Kim, Gwang Ho Baik, Ju Yup Lee, Kyung Sik Park, Jeong Eun Shin, Hyun Joo Song, Dae-Seong Myung ... , Suck Chei Choi, Hyun Jin Kim, Jeong Yoon Yim. Formal analysis: Seon Hee Lim, Nayoung Kim, Jin Won Kwon. Funding acquisition: Nayoung Kim. 16 / 18 Investigation: Seon Hee Lim, Sung Eun Kim, Gwang Ho

Effects of Alkaline-Reduced Drinking Water on Irritable Bowel Syndrome with Diarrhea: A Randomized Double-Blind, Placebo-Controlled Pilot Study

Choi,1 Cheol Min Shin,1 Young Soo Park,1 Nayoung Kim,1 and Dong Ho Lee1,2 1Department of Internal Medicine and Seoul National University Bundang Hospital, Seongnam, Gyeonggi-do, Republic of Korea ... drafted the manuscript. Hyuk Yoon and Dong Ho Lee designed the study and revised the manuscript. Hyun Soo Kim, Yoon Jin Choi, Cheol Min Shin, Young Soo Park, and Nayoung Kim critically reviewed the

Is endoscopic surveillance necessary for patients who undergo total gastrectomy for gastric cancer?

. Formal analysis: Sung Jae Park, Young Soo Park, Hyuk Yoon, Cheol Min Shin. Supervision: Young Soo Park, Nayoung Kim, Dong Ho Lee. Writing ? original draft: Sung Jae Park. Writing ? review & editing ... : Young Soo Park, Hyuk Yoon, Cheol Min Shin, Nayoung Kim. 10 / 11 1. Marrelli D , De Stefano A , de Manzoni G , Morgagni P , Di Leo A , Roviello F . Prediction of recurrence after radical surgery for

Molecular checkpoints controlling natural killer cell activation and their modulation for cancer immunotherapy

for Nayoung Kim in:Nature Research journals • PubMed • Google ScholarSearch for Hun Sik Kim in:Nature Research journals • PubMed • Google Scholar Competing interests The authors declare no conflict of ... interest. Corresponding authors Correspondence to Nayoung Kim or Hun Sik Kim. Rights and permissions This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International

The relationship between drinking alcohol and esophageal, gastric or colorectal cancer: A nationwide population-based cohort study of South Korea

: Hyun Soo Kim. Software: Kyung-Do Han. Supervision: Nayoung Kim. Writing ± original draft: Yoon Jin Choi. Writing ± review & editing: Hyun Soo Kim, Hyuk Yoon, Cheol Min Shin, Young Soo Park. 11 / 13

Probiotics reduce repeated water avoidance stress-induced colonic microinflammation in Wistar rats in a sex-specific manner

: Nayoung Kim, Hyuk Yoon. Data curation: Ju Yup Lee. Formal analysis: Ju Yup Lee. Funding acquisition: Nayoung Kim. Investigation: Ryoung Hee Nam, Sung Hwa Sohn, Sun Min Lee, Daeun Choi, Hye Seung Lee ... . Methodology: Hyuk Yoon, Yong Sung Kim. Supervision: Nayoung Kim, Dong Ho Lee. Writing ± original draft: Ju Yup Lee. Writing ± review & editing: Nayoung Kim, Yong Sung Kim. 12 / 14 13 / 14 1. Longstreth GF

Elevated serum gamma-glutamyltransferase is associated with an increased risk of oesophageal carcinoma in a cohort of 8,388,256 Korean subjects

Gamma-glutamyltransferase (GGT) is a marker for hepatic injury and alcohol consumption. However, the association of GGT with the risk of oesophageal carcinoma (OC) has not been fully recognized to date. Therefore, this study aimed to determine the association between elevated GGT and OC, by also considering the body mass index (BMI) of the subjects. Clinical data from 8,388,256...

Changes in the interstitial cells of Cajal and neuronal nitric oxide synthase positive neuronal cells with aging in the esophagus of F344 rats

peristalsis and LES relaxation. Author Contributions Conceptualization: Nayoung Kim. Data curation: Ryoung Hee Nam, Sun Min Lee, Ji Hyun Park, Daeun Choi. Formal analysis: Hee Jin Kim, Ryoung Hee Nam, Sun ... Min Lee, Ji Hyun Park, Daeun Choi, Min-Seob Kim, Moon Young Lee. Investigation: Ryoung Hee Nam, Ji Hyun Park, Daeun Choi, Min-Seob Kim, Moon Young Lee. 14 / 17 Methodology: Nayoung Kim, Hye Seung

Transmission of Porcine Endogenous Retrovirus Produced from Different Recipient Cells In Vivo

Humanized pigs have been developed to reduce the incidence of immune rejection in xenotransplantation, but significant concerns remain, such as transmission of viral zoonosis. Porcine endogenous retroviruses (PERV), which exist in the genome of pigs, are produced as infectious virions from all porcine cells and cause zoonosis. Here, we examined the possibility of zoonosis of...

Basal joint arthroplasty decreases carpal tunnel pressure

Background There is a well-documented association between carpal tunnel syndrome (CTS) and thumb carpometacarpal (CMC) arthritis, and these conditions commonly coexist. We have observed that patients who have previously undergone thumb basal joint arthroplasty (BJA) seem rarely to present subsequently with CTS. Our hypothesis is that BJA decreases the pressure within the carpal...

Measurement of the radiographic anatomy of the small and ring metacarpals using computerized tomographic scans

Background To date, only plain radiographic definitions of normal anatomical parameters have been described. Our study aims to describe normal anatomic measurements of small and ring metacarpals using a novel digital reconstruction technique based on raw CT image data. We hypothesize that current plain radiographic data incorrectly describes normal metacarpal anatomy in the...

Change in the Interstitial Cells of Cajal and nNOS Positive Neuronal Cells with Aging in the Stomach of F344 Rats

The gastric accommodation reflex is an important mechanism in gastric physiology. However, the aging-associated structural and functional changes in gastric relaxation have not yet been established. Thus, we evaluated the molecular changes of interstitial cell of Cajal (ICC) and neuronal nitric oxide synthase (nNOS) and the function changes in the corpus of F344 rats at different...

Routine use of locking shaft screws is not necessary in volar plate fixation of distal radius fractures

Hypothesis Volar locking plate fixation is a common treatment method for distal radius fractures. Recently, implants have been designed with an option to use locking screws in the shaft portion of the plate. While there is a high incidence of low bone mineral density in patients who sustain fragility fractures of the distal radius, the need for locking shaft screws is not well...

HIV-1 Tat second exon limits the extent of Tat-mediated modulation of interferon-stimulated genes in antigen presenting cells

Kim Mariana Manrique Anna Aldovini 0 Equal contributors Department of Pediatrics, Harvard Medical School, Department of Medicine, Boston Children's Hospital , 300 Longwood Avenue, Boston, MA 02115