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Molecular basis for the inhibition of β-hydroxyacyl-ACP dehydratase HadAB complex from Mycobacterium tuberculosis by flavonoid inhibitors

-resistant. COMPLIANCE WITH ETHICS GUIDELINES Yu Dong, Xiaodi Qiu, Neil Shaw, Yueyang Xu, Yuna Sun, Xuemei Li, Jun Li and Zihe Rao declare that they have no conflict of interest. This article does not

Binding of bacterial secondary messenger molecule c di-GMP is a STING operation

Initial skirmishes between the host and pathogen result in spillage of the contents of the bacterial cell. Amongst the spillage, the secondary messenger molecule, cyclic dimeric guanosine monophosphate (c di-GMP), was recently shown to be bound by stimulator of interferon genes (STING). Binding of c di-GMP by STING activates the Tank Binding Kinase (TBK1) mediated signaling...

Structural View of a Non Pfam Singleton and Crystal Packing Analysis

Background Comparative genomic analysis has revealed that in each genome a large number of open reading frames have no homologues in other species. Such singleton genes have attracted the attention of biochemists and structural biologists as a potential untapped source of new folds. Cthe_2751 is a 15.8 kDa singleton from an anaerobic, hyperthermophile Clostridium thermocellum. To...

Mechanism of the Rpn13-induced activation of Uch37

SAXS; Ub, ubiquitin; Ub-AMC, ubiquitin-7-amino-4methylcoumarin; UCH, ubiquitin C-terminal hydrolase. COMPLIANCE WITH ETHICS GUIDELINES Lianying Jiao, Songying Ouyang, Neil Shaw, Gaojie Song, Yingang

Structural analysis of asparaginyl endopeptidase reveals the activation mechanism and a reversible intermediate maturation stage

Academy of Sciences, Beijing 100101, ChinaLixia Zhao, Tian Hua, Heng Ru, Xiangmin Ni, Neil Shaw, Lianying Jiao, Wei Ding, Lu Qu, Songying Ouyang & Zhi-Jie LiuiHuman Institute, ShanghaiTech University ... ScholarSearch for Heng Ru in:Nature Research journals • PubMed • Google ScholarSearch for Xiangmin Ni in:Nature Research journals • PubMed • Google ScholarSearch for Neil Shaw in:Nature Research journals • PubMed

Structural Basis and Catalytic Mechanism for the Dual Functional Endo-β-N-Acetylglucosaminidase A

Mechanism for the Dual Functional Endo-b-N-Acetylglucosaminidase A Jie Yin Lei Li Neil Shaw Yang Li Jing Katherine Song Wenpeng Zhang Chengfeng Xia Rongguang Zhang Andrzej Joachimiak Hou-Cheng Zhang Lai-Xi

(NZ)CH...O Contacts assist crystallization of a ParB-like nuclease

Background The major bottleneck for determination of 3 D structures of proteins using X-rays is the production of diffraction quality crystals. Often proteins are subjected to chemical modification to improve the chances of crystallization Results Here, we report the successful crystallization of a nuclease employing a reductive methylation protocol. The key to crystallization...