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Genetic diversity maintained among fragmented populations of a tree undergoing range contraction

in:Nature Research journals • PubMed • Google Scholar Search for Nian Wang in:Nature Research journals • PubMed • Google Scholar Search for Richard A. Nichols in:Nature Research journals • PubMed • Google ... This work was funded by NERC Fellowship NE/G01504X/1 to Richard Buggs. James Borrell was funded by NERC CASE studentship NE/J017388/1 in collaboration with Trees for Life and Highland Birchwoods. Nian

An equation-of-state-meter of quantum chromodynamics transition from deep learning

A primordial state of matter consisting of free quarks and gluons that existed in the early universe a few microseconds after the Big Bang is also expected to form in high-energy heavy-ion collisions. Determining the equation of state (EoS) of such a primordial matter is the ultimate goal of high-energy heavy-ion experiments. Here we use supervised learning with a deep...

Genome-wide analysis and expression profiles of glyoxalase gene families in Chinese cabbage (Brassica rapa L)

. Data curation: Xiaoming Wu. Formal analysis: Guixin Yan, Jiangwei Qiao. Funding acquisition: Xiaoming Wu. Investigation: Xin Xiao, Guizhen Gao, Kun Xu. Methodology: Guixin Yan, Nian Wang. Project ... administration: Xiaoming Wu. Software: Guixin Yan, Nian Wang, Jiangwei Qiao. Supervision: Guixin Yan, Xiaoming Wu. Validation: Guixin Yan, Xin Xiao, Fugui Zhang, Guizhen Gao, Kun Xu, Biyun Chen. Visualization

The Mechanism of Sharing Tacit Knowledge Based on Multi-Agent Systems

The effective application of knowledge management in organizations is an essential factor in their successful operation. Furthermore, it is more important that how people exploit tacit knowledge, how they make tacit knowledge beneficial to the organization. Sharing tacit knowledge within an organization is critical to the organization among the individuals and between the...

Transcriptome analysis of root response to citrus blight based on the newly assembled Swingle citrumelo draft genome

Wang 0 0 Citrus Research and Education Center, Department of Microbiology and Cell Science, IFAS, University of Florida , Lake Alfred, FL , USA 1 Citrus Research and Education Center, Department of

Development of a Microemulsion Formulation for Antimicrobial SecA Inhibitors

In our previous study, we have identified five antimicrobial small molecules via structure based design, which inhibit SecA of Candidatus Liberibacter asiaticus (Las). SecA is a critical protein translocase ATPase subunit and is involved in pre-protein translocation across and integration into the cellular membrane in bacteria. In this study, eleven compounds were identified...

Budesonide ameliorates lung injury induced by large volume ventilation

Background Ventilation-induced lung injury (VILI) is a health problem for patients with acute respiratory dysfunction syndrome. The aim of this study was to investigate the effectiveness of budesonide in treating VILI. Methods Twenty-four rats were randomized to three groups: a ventilation group, ventilation/budesonide group, and sham group were ventilated with 30 ml/kg tidal...

Budesonide ameliorates lung injury induced by large volume ventilation

Ventilation-induced lung injury (VILI) is a health problem for patients with acute respiratory dysfunction syndrome. The aim of this study was to investigate the effectiveness of budesonide in treating VILI. Twenty-four rats were randomized to three groups: a ventilation group, ventilation/budesonide group, and sham group were ventilated with 30 ml/kg tidal volume or only...

An effector from the Huanglongbing-associated pathogen targets citrus proteases

A. L. van der Hoorn in:Nature Research journals • PubMed • Google Scholar Search for Nian Wang in:Nature Research journals • PubMed • Google Scholar Search for Gitta Coaker in:Nature Research

Targeted Genome Editing of Sweet Orange Using Cas9/sgRNA

Genetic modification, including plant breeding, has been widely used to improve crop yield and quality, as well as to increase disease resistance. Targeted genome engineering is expected to contribute significantly to future varietal improvement, and genome editing technologies using zinc finger nucleases (ZFNs), transcription activator-like effector nucleases (TALENs), and...

The ATP-dependent RNA helicase HrpB plays an important role in motility and biofilm formation in Xanthomonas citri subsp. citri

Background RNA helicases are enzymes that catalyze the separation of double-stranded RNA (dsRNA) using the free energy of ATP binding and hydrolysis. DEAD/DEAH families participate in many different aspects of RNA metabolism, including RNA synthesis, RNA folding, RNA-RNA interactions, RNA localization and RNA degradation. Several important bacterial DEAD/DEAH-box RNA helicases...

Host immune responses accelerate pathogen evolution

Pathogens face a hostile and often novel environment when infecting a new host, and adaptation is likely to be an important determinant of the success in colonization and establishment. We hypothesized that resistant hosts will impose stronger selection on pathogens than susceptible hosts, which should accelerate pathogen evolution through selection biased toward effector genes...

Synchronized Dual Pulse Gastric Electrical Stimulation Induces Activation of Enteric Glial Cells in Rats with Diabetic Gastroparesis

Objective. The aims of this study were to investigate the effects of synchronized dual pulse gastric electrical stimulation (SGES) on gastric motility in different periods for diabetic rats and try to explore the possible mechanisms of the effects. Methods. Forty-six rats were used in the study. Gastric slow waves were recorded at baseline, 7–14-day diabetes and 56–63-day...

The Post-transcriptional Regulator rsmA/csrA Activates T3SS by Stabilizing the 5′ UTR of hrpG, the Master Regulator of hrp/hrc Genes, in Xanthomonas

The RsmA/CsrA family of the post-transcriptional regulators of bacteria is involved in the regulation of many cellular processes, including pathogenesis. In this study, we demonstrated that rsmA not only is required for the full virulence of the phytopathogenic bacterium Xanthomonas citri subsp. citri (XCC) but also contributes to triggering the hypersensitive response (HR) in...

Leptin promotes epithelial-mesenchymal transition of breast cancer via the upregulation of pyruvate kinase M2

Background Accumulating researches have shown that epithelial-mesenchymal transition (EMT) contributes to tumor metastasis. Leptin, a key adipokine secreted from adipocytes, shapes the tumor microenvironment, potentiates the migration of breast cancer cells and angiogenesis, and is also involved in EMT. However, the potential mechanism remains unknown. This study aims to explore...

Breeding histories and selection criteria for oilseed rape in Europe and China identified by genome wide pedigree dissection

journals • PubMed • Google Scholar Search for Yan Long in:Nature Research journals • PubMed • Google Scholar Search for Nian Wang in:Nature Research journals • PubMed • Google Scholar Search for Jun Zou

The gpsX gene encoding a glycosyltransferase is important for polysaccharide production and required for full virulence in Xanthomonas citri subsp. citri

Background The Gram-negative bacterium Xanthomonas citri subsp. citri (Xac) causes citrus canker, one of the most destructive diseases of citrus worldwide. In our previous work, a transposon mutant of Xac strain 306 with an insertion in the XAC3110 locus was isolated in a screening that aimed at identifying genes related to biofilm formation. The XAC3110 locus was named as bdp24...

The Development and Verification of a Novel ECMS of Hybrid Electric Bus

This paper presents the system modeling, control strategy design, and hardware-in-the-loop test for a series-parallel hybrid electric bus. First, the powertrain mathematical models and the system architecture were proposed. Then an adaptive ECMS is developed for the real-time control of a hybrid electric bus, which is investigated and verified in a hardware-in-the-loop simulation...

Construction of a high-density genetic map and QTLs mapping for sugars and acids in grape berries

Background QTLs controlling individual sugars and acids (fructose, glucose, malic acid and tartaric acid) in grape berries have not yet been identified. The present study aimed to construct a high-density, high-quality genetic map of a winemaking grape cross with a complex parentage (V. vinifera × V. amurensis) × ((V. labrusca × V. riparia) × V. vinifera), using next-generation...

Informative gene selection using the Algebraic Connectivity Strength of Point and Scoring Criteria

This paper presents a novel method that integrates the Algebraic Connectivity Strength of Point (ACSP) and Scoring Criteria to identify genes associated with tumor type. First, for each gene, the ACSP is used to identify reliable expression levels of the gene in all the samples. The informative genes are then selected using Scoring Criteria based on these reliable expression...