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16 papers found.
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Therapeutic hypothermia and coronary angiography are mandatory after out-of-hospital cardiac arrest: No

Hans Friberg Niklas Nielsen - Fig. 1 KaplanMeier estimates for time to death in the TTM trial intervention groups. From New England Journal of Medicine, Nielsen et al, Targeted Temperature

Evaluation of the Impact of Alveolar Nitrogen Excretion on Indices Derived from Multiple Breath Nitrogen Washout

Background A large body of evidence has now accumulated describing the advantages of multiple breath washout tests over conventional spirometry in cystic fibrosis (CF). Although the majority of studies have used exogenous sulphur hexafluoride (SF6) as the tracer gas this has also led to an increased interest in nitrogen washout tests, despite the differences between these methods...

MicroRNAs: new biomarkers and therapeutic targets after cardiac arrest?

Nielsen for the Biomarker subcommittee of the TTM trial (Target Temperature Management After Cardiac Arrest NCT 0 Laboratory of Cardiovascular Research, Luxembourg Institute of Health , L-1526 Luxembourg

Single versus Serial Measurements of Neuron-Specific Enolase and Prediction of Poor Neurological Outcome in Persistently Unconscious Patients after Out-Of-Hospital Cardiac Arrest – A TTM-Trial Substudy

Background Prediction of neurological outcome is a crucial part of post cardiac arrest care and prediction in patients remaining unconscious and/or sedated after rewarming from targeted temperature management (TTM) remains difficult. Current guidelines suggest the use of serial measurements of the biomarker neuron-specific enolase (NSE) in combination with other predictors of...

A structured approach to neurologic prognostication in clinical cardiac arrest trials

Brain injury is the dominant cause of death for cardiac arrest patients who are admitted to an intensive care unit, and the majority of patients die after withdrawal of life sustaining therapy (WLST) based on a presumed poor neurologic outcome. Mild induced hypothermia was found to decrease the reliability of several methods for neurological prognostication. Algorithms for...

Clinical review: Continuous and simplified electroencephalography to monitor brain recovery after cardiac arrest

There has been a dramatic change in hospital care of cardiac arrest survivors in recent years, including the use of target temperature management (hypothermia). Clinical signs of recovery or deterioration, which previously could be observed, are now concealed by sedation, analgesia, and muscle paralysis. Seizures are common after cardiac arrest, but few centers can offer high...

Intravascular versus surface cooling for targeted temperature management after out-of-hospital cardiac arrest – an analysis of the TTM trial data

Christian Hassager 5 Janneke Horn 5 Jesper Kjaergaard 5 Michael Kuiper 5 Tommaso Pellis 5 Pascal Stammet 5 Michael Wanscher 5 Jørn Wetterslev 5 Hans Friberg 5 Niklas Nielsen 5 0 Department of Critical Care

Electroencephalography (EEG) for neurological prognostication after cardiac arrest and targeted temperature management; rationale and study design

Erik Westhall 0 Ingmar Rosn 0 Andrea O Rossetti Anne-Fleur van Rootselaar Troels Wesenberg Kjaer Janneke Horn Susann Ulln Hans Friberg Niklas Nielsen Tobias Cronberg 0 Department of Clinical

Association of gender to outcome after out-of-hospital cardiac arrest – a report from the International Cardiac Arrest Registry

Niklas Nielsen 1 Karl B Kern Michael R Mooney Richard R Riker Sten Rubertsson David B Seder Pascal Stammet Kjetil Sunde Eldar Sreide Barbara T Unger Hans Friberg 0 1 0 Department of Anaesthesiology and

Cognitive function after cardiac arrest and temperature management; rationale and description of a sub-study in the Target Temperature Management trial

Background Mild to moderate cognitive impairment is common amongst long-term survivors of cardiac arrest. In the Target Temperature Management trial (TTM-trial) comatose survivors were randomized to 33°C or 36°C temperature control for 24 hours after cardiac arrest and the effects on survival and neurological outcome assessed. This protocol describes a sub-study of the TTM-trial...

Detailed statistical analysis plan for the target temperature management after out-of-hospital cardiac arrest trial

Background Animal experimental studies and previous randomized trials suggest an improvement in mortality and neurological function with temperature regulation to hypothermia after cardiac arrest. According to a systematic review, previous trials were small, had a risk of bias, evaluated select populations, and did not treat hyperthermia in the control groups. The optimal target...

Management and outcome of mechanically ventilated patients after cardiac arrest

Iole Brunetti 0 Konstantinos Raymondos Davide D'Antini Niklas Nielsen Niall D Ferguson Bernd W Böttiger Arnaud W Thille Andrew R Davies Javier Hurtado Fernando Rios Carlos Apezteguía Damian A Violi Nahit ... Dr Bernd W Böttiger is a director of Science and Research of European Resuscitation Council. Dr Niklas Nielsen received payment for lecture from BARD medical (not related to the current article). Dr

Transfusion requirements in septic shock (TRISS) trial - comparing the effects and safety of liberal versus restrictive red blood cell transfusion in septic shock patients in the ICU: protocol for a randomised controlled trial

Elsebeth Haunstrup Omar Rian Anders Oldner Asger Bendtsen Susanne Iversen Jrn-ge Langva Rasmus B Johansen Niklas Nielsen Ville Pettil Matti Reinikainen Dorte Keld Siv Leivdal Jan-Michael Breider Inga Tjder