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Targeted delivery of mannosylated-PLGA nanoparticles of antiretroviral drug to brain

Targeted delivery of mannosylated-PLGA nanoparticles of anti-retroviral drug to brain Bhavin K Patel, Rajesh H Parikh, Nilesh Patel Department of Pharmaceutics and Pharmaceutical Technology ... delivery of the drug into brain macrophages. - Bhavin K patel rajesh h parikh Nilesh patel Department of pharmaceutics and pharmaceutical Technology, r amanbhai patel College of pharmacy, Charotar

A Comparison of Drug Transport in Pulmonary Absorption Models: Isolated Perfused rat Lungs, Respiratory Epithelial Cell Lines and Primary Cell Culture

Purpose To evaluate the ability of human airway epithelial cell layers and a simple rat isolated perfused lung (IPL) model to predict pulmonary drug absorption in rats in vivo. Method The permeability of seven compounds selected to possess a range of lipophilicity was measured in two airway cell lines (Calu-3 and 16HBE14o-), in normal human bronchial epithelial (NHBE) cells and...

Our Experience in the Management of Traumatic Wound Myiasis: Report of 3 Cases and Review of the Literature

Compromised health and hygiene can lead to many complications and one among them is traumatic wound myiasis. Myiasis is the invasion of living tissues by larvae of flies. Three cases of traumatic orofacial wound myiasis and treatment strategies followed for the management of them are reported in this paper.

Use of 4-factor prothrombin complex concentrate in the treatment of a gastrointestinal hemorrhage complicated by dabigatran

Target-specific oral anticoagulants (TSOACs) provide patients and healthcare providers with an alternative to vitamin K antagonists (VKA). The TSOACs are of similar or superior efficacy to warfarin, but unlike VKAs, there are no approved ‘antidotes’ for rapid reversal of life-threatening bleeding on therapy. We report here the case of an 83-year-old gentleman, who presented to...