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Search: authors:"Nobuharu Tamaki"

9 papers found.
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New diagnostic technique to evaluate hepatic steatosis using the attenuation coefficient on ultrasound B mode

) Author Contributions Conceptualization: Masashi Hirooka, Yoichi Hiasa. Data curation: Yohei Koizumi, Masashi Hirooka. Formal analysis: Yohei Koizumi, Osamu Nakashima. Supervision: Nobuharu Tamaki

Real-life experience of lusutrombopag for cirrhotic patients with low platelet counts being prepared for invasive procedures

Background and aims The present study aimed to report our real-life experience of the TPO receptor agonist lusutrombopag for cirrhotic patients with low platelet counts. Methods We studied platelet counts in 1,760 cirrhotic patients undergoing invasive procedures at our hospital between January 2014 and December 2017. In addition, we studied 25 patients who were administered...

Impact of pre-sarcopenia in sorafenib treatment for advanced hepatocellular carcinoma

Takahashi, Jun Itakura, Kaoru Tsuchiya, Yutaka Yasui, Nobuharu Tamaki, Kenta Takaura, Yasuyuki Komiyama, Mayu Higuchi, Youhei Kubota, Wann Wang, Mao Okada, Nobuyuki Enomoto, Namiki Izumi. 10 / 12 11 / 12 1

Prediction of diuretic response to tolvaptan by a simple, readily available spot urine Na/K ratio

Background Tolvaptan is vasopressin type 2 receptor antagonist that inhibits water reabsorption. It is used in combination with standard diuretics to treat ascites unresponsive to standard diuretic therapy or hyponatremia because of liver cirrhosis. This study evaluated the effectiveness and safety of tolvaptan in clinical practice and aimed to determine the factors related to...

Correction: Elastin Fiber Accumulation in Liver Correlates with the Development of Hepatocellular Carcinoma

Yoshida Tsuguru Hayashi Konomi Kuwabara Kenta Takaura Natsuko Nakakuki Hitomi Takada Nobuharu Tamaki Shoko Suzuki Hiroyuki Nakanishi Kaoru Tsuchiya Jun Itakura Yuka Takahashi Akinori Hashiguchi Michiie

Resistance-Associated NS5A Variants of Hepatitis C Virus Are Susceptible to Interferon-Based Therapy

Background & Aims The presence of resistance-associated variants (RAVs) of hepatitis C virus (HCV) attenuates the efficacy of direct acting antivirals (DAAs). The objective of this study was to characterize the susceptibility of RAVs to interferon-based therapy. Methods Direct and deep sequencing were performed to detect Y93H RAV in the NS5A region. Twenty nine genotype 1b...

Genetic Polymorphisms of IL28B and PNPLA3 Are Predictive for HCV Related Rapid Fibrosis Progression and Identify Patients Who Require Urgent Antiviral Treatment with New Regimens

The assessment of individual risk of fibrosis progression in patients with chronic hepatitis C is an unmet clinical need. Recent genome-wide association studies have highlighted several genetic alterations as predictive risk factors of rapid fibrosis progression in chronic hepatitis C. However, most of these results require verification, and whether the combined use of these...

Pretreatment Gastric Lavage Reduces Postoperative Bleeding after Endoscopic Submucosal Dissection for Gastric Neoplasms

Aim For patients receiving endoscopic submucosal dissection (ESD), there is urgent need pertaining to the prevention of postoperative bleeding. We conducted a retrospective propensity score-matched study that evaluated whether pre-ESD gastric lavage prevents postoperative bleeding after ESD for gastric neoplasms. Methods From September 2002 to October 2015, the 760 consecutive...

Elastin Fiber Accumulation in Liver Correlates with the Development of Hepatocellular Carcinoma

Background & Aims The fibrosis stage, which is evaluated by the distribution pattern of collagen fibers, is a major predictor for the development of hepatocellular carcinoma (HCC) for patients with hepatitis C. Meanwhile, the role of elastin fibers has not yet been elucidated. The present study was conducted to determine the significance of quantifying both collagen and elastin...