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Closed Reduction in a “Hyperextended Supine Position” with Percutaneous Transsacral-Transiliac and Iliosacral Screw Fixation for Denis Zone III Sacral Fractures

Nobuyuki Takahashi,2 Mitsumasa Chiba,2 and Toshihiko Yamashita2 1Department of Emergency Medicine Advanced Critical Care and Emergency Center, Sapporo Medical University School of Medicine, Sapporo, Japan

Preference and strategy in proposer’s prosocial giving in the ultimatum game

, Nobuyuki Takahashi. 13 / 15 Formal analysis: Misato Inaba, Toshio Yamagishi. Funding acquisition: Toshio Yamagishi. Investigation: Misato Inaba, Yumi Inoue, Toshio Yamagishi. Project administration ... : Satoshi Akutsu, Toshio Yamagishi. Resources: Nobuyuki Takahashi. Software: Misato Inaba. Supervision: Toshio Yamagishi. Writing ± original draft: Misato Inaba. Writing ± review & editing: Yumi Inoue

Hepatic dysfunction and thrombocytopenia induced by excess sFlt1 in mice lacking endothelial nitric oxide synthase

Research journals • PubMed • Google Scholar Search for Nobuyuki Takahashi in:Nature Research journals • PubMed • Google Scholar Contributions Y.O., K.M., T.F. and E.S. performed experiments. Y.O. and N.T ... Correspondence to Nobuyuki Takahashi. Electronic supplementary material Supporting information Rights and permissions Open Access This article is licensed under a Creative Commons Attribution 4.0

Comment on Kramer et al. Glucagon Response to Oral Glucose Challenge in Type 1 Diabetes: Lack of Impact of Euglycemia. Diabetes Care 2014;37:1076–1082

Nobuyuki Takahashi Tetsuro Tsujimoto Hiroshi Kajio - We have read the study by Kramer et al. (1) concerning glucagon response to oral glucose challenge in type 1 diabetes with great interest

Fish oil intake induces UCP1 upregulation in brown and white adipose tissue via the sympathetic nervous system

Food, Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Uji, Kyoto 611-0011, JapanMinji Kim, Tsuyoshi Goto, Nobuyuki Takahashi & Teruo KawadaResearch Unit for ... Physiological Chemistry, Kyoto University, Kyoto 606-8501, JapanTsuyoshi Goto, Nobuyuki Takahashi & Teruo KawadaDepartment of Food Science and Nutrition, University of Ulsan, Ulsan 680-749, South KoreaRina

Reduced Uterine Perfusion Pressure (RUPP) Model of Preeclampsia in Mice

Preeclampsia (PE) is a pregnancy-induced hypertension with proteinuria that typically develops after 20 weeks of gestation. A reduction in uterine blood flow causes placental ischemia and placental release of anti-angiogenic factors such as sFlt-1 followed by PE. Although the reduced uterine perfusion pressure (RUPP) model is widely used in rats, investigating the role of genes...

Absence of in vivo selection for K13 mutations after artemether–lumefantrine treatment in Uganda

Background Individual drug treatment may select resistant parasites in the human body, a process termed in vivo selection. Some single nucleotide polymorphisms in Plasmodium falciparum chloroquine-resistance transporter (pfcrt) and multidrug resistance gene 1 (pfmdr1) genes have been reportedly selected after artemether–lumefantrine treatment. However, there is a paucity of data...

Network Homophily and the Evolution of the Pay-It-Forward Reciprocity

The pay-it-forward reciprocity is a type of cooperative behavior that people who have benefited from others return favors to third parties other than the benefactors, thus pushing forward a cascade of kindness. The phenomenon of the pay-it-forward reciprocity is ubiquitous, yet how it evolves to be part of human sociality has not been fully understood. We develop an evolutionary...

Metabolic alterations by indoxyl sulfate in skeletal muscle induce uremic sarcopenia in chronic kidney disease

Daisuke Saigusa Daisuke Miura Tomomi Morikawa-Ichinose Ritsumi Saito Ikuko Oba-Yabana Yuji Oe Kiyomi Kisu Eri Naganuma Kenji Koizumi Takayuki Mokudai Yoshimi Niwano Tai Kudo Chitose Suzuki Nobuyuki ... Takahashi Hiroshi Sato Takaaki Abe Toshimitsu Niwa Sadayoshi Ito OPEN Sarcopenia is associated with increased morbidity and mortality in chronic kidney disease (CKD). Pathogenic mechanism of skeletal muscle

Various Terpenoids Derived from Herbal and Dietary Plants Function as PPAR Modulators and Regulate Carbohydrate and Lipid Metabolism

Several herbal plants improve medical conditions. Such plants contain many bioactive phytochemicals. Terpenoids (also called “isoprenoids“) constitute one of the largest families of natural products accounting for more than 40,000 individual compounds of both primary and secondary metabolisms. In particular, terpenoids are contained in many herbal plants, and several terpenoids...

Functional Food Targeting the Regulation of Obesity-Induced Inflammatory Responses and Pathologies

Obesity is associated with a low-grade systemic chronic inflammatory state, characterized by the abnormal production of pro- and anti-inflammatory adipocytokines. It has been found that immune cells such as macrophages can infiltrate adipose tissue and are responsible for the majority of inflammatory cytokine production. Obesity-induced inflammation is considered a potential...

Decreased plasma level of vitamin C in chronic kidney disease: comparison between diabetic and non-diabetic patients

Background. A decreased plasma level of vitamin C has been reported to be associated with an increased risk of cardiovascular morbidity and mortality. Here, we sought to determine the vitamin C status of patients with chronic kidney disease and the pathophysiological role of vitamin C in these patients. Methods. We studied 58 patients and evaluated the relationship between renal...

Maxi-anion channel as a candidate pathway for osmosensitive ATP release from mouse astrocytes in primary culture

In the present study, we aimed to evaluate the pathways contributing to ATP release from mouse astrocytes during hypoosmotic stress. We first examined the expression of mRNAs for proteins constituting possible ATP-releasing pathways that have been suggested over the past several years. In RT-PCR analysis using both control and osmotically swollen astrocytes, amplification of cDNA...

Limited Geographical Origin and Global Spread of Sulfadoxine-Resistant dhps Alleles in Plasmodium falciparum Populations

Toshihiro Mita Meera Venkatesan Jun Ohashi Richard Culleton Nobuyuki Takahashi Takahiro Tsukahara Mathieu Ndounga Lek Dysoley Hiroyoshi Endo Francis Hombhanje Marcelo U. Ferreira Christopher V. Plowe

Potent PPARα Activator Derived from Tomato Juice, 13-oxo-9,11-Octadecadienoic Acid, Decreases Plasma and Hepatic Triglyceride in Obese Diabetic Mice

Dyslipidemia is a major risk factor for development of several obesity-related diseases. The peroxisome proliferator-activated receptor α (PPARα) is a ligand-activated transcription factor that regulates energy metabolism. Previously, we reported that 9-oxo-10,12-octadecadienoic acid (9-oxo-ODA) is presented in fresh tomato fruits and acts as a PPARα agonist. In addition to 9-oxo...

Large-scale survey for novel genotypes of Plasmodium falciparum chloroquine-resistance gene pfcrt

Background In Plasmodium falciparum, resistance to chloroquine (CQ) is conferred by a K to T mutation at amino acid position 76 (K76T) in the P. falciparum CQ transporter (PfCRT). To date, at least 15 pfcrt genotypes, which are represented by combinations of five amino acids at positions 72-76, have been described in field isolates from various endemic regions. To identify novel...

Efficacy of an L- and N-type calcium channel blocker in hypertensive patients with neurovascular compression of the rostral ventrolateral medulla

, JapanYasuko Aota, Satoshi Morimoto, Takao Sakuma, Tatsuyori Morita, Fusakazu Jo, Nobuyuki Takahashi & Toshiji IwasakaDepartment of Radiology, Kansai Medical University, Osaka, JapanMinoru Maehara, Koshi Ikeda ... ScholarSearch for Nobuyuki Takahashi in:Nature Research journals • PubMed • Google ScholarSearch for Minoru Maehara in:Nature Research journals • PubMed • Google ScholarSearch for Koshi Ikeda in:Nature Research

Pulmonary-renal syndrome in systemic sclerosis: a report of three cases and review of the literature

We describe three cases of acute renal failure with diffuse alveolar hemorrhage, which is designated pulmonary-renal syndrome (PRS), in systemic sclerosis (SSc) and review the literature to better define this rare but severe complication of SSc. The clinical course of three SSc patients with acute renal failure and concomitant diffuse alveolar hemorrhage are reported, and the...

Failure to detect Plasmodium vivax in West and Central Africa by PCR species typing

Giacomo M Paganotti 4 Nobuyuki Takahashi 1 Akira Kaneko 5 Hideaki Eto 1 Halidou Tinto 2 Corine Karema 10 Umberto D'Alessandro 8 Virgilio do Rosário 6 Takatoshi Kobayakawa 1 Francine Ntoumi 9 Richard