Advanced search    

Search: authors:"Noorjahan Panjwani"

12 papers found.
Use AND, OR, NOT, +word, -word, "long phrase", (parentheses) to fine-tune your search.

Dynasore protects the ocular surface against damaging stress

: Noorjahan Panjwani, Pablo Argu?eso, Joseph T. Barr, Shinwu Jeong, M. Elizabeth Fini. Data curation: Andrew Webster, Shravan K. Chintala, Shinwu Jeong, M. Elizabeth Fini. Formal analysis: Andrew Webster ... Jeong, M. Elizabeth Fini. Methodology: Andrew Webster, Shravan K. Chintala, Jasmine Kim, Michelle Ngan, Tatsuo Itakura, Noorjahan Panjwani, Pablo Argu?eso, Joseph T. Barr, Shinwu Jeong, M. Elizabeth Fini

Glycobiology of ocular angiogenesis

Ocular neovascularization can affect almost all the tissues of the eye: the cornea, the iris, the retina, and the choroid. Pathological neovascularization is the underlying cause of vision loss in common ocular conditions such as diabetic retinopathy, retinopathy of prematurity and age-related macular neovascularization. Glycosylation is the most common covalent posttranslational...

Molecular basis for MMP9 induction and disruption of epithelial cell–cell contacts by galectin-3

Zhiyi Cao Noorjahan Panjwani Pablo Argu eso () Dynamic modulation of the physical contacts between neighboring cells is integral to epithelial processes such as tissue repair and cancer dissemination

Erratum: Pathological lymphangiogenesis is modulated by galectin-8-dependent crosstalk between podoplanin and integrin-associated VEGFR-3

Sugaya Maria J. Lopez Victor G. Sendra Nora Laver Hakon Leffler Ulf J. Nilsson Jianxin Fu Jianhua Song Lijun Xia Pedram Hamrah Noorjahan Panjwani Nature Communications 7:11302 doi: 10.1038/ncomms11302

Pathological lymphangiogenesis is modulated by galectin-8-dependent crosstalk between podoplanin and integrin-associated VEGFR-3

in:Nature Research journals • PubMed • Google ScholarSearch for Pedram Hamrah in:Nature Research journals • PubMed • Google ScholarSearch for Noorjahan Panjwani in:Nature Research journals • PubMed • Google ... author Correspondence to Noorjahan Panjwani. Supplementary information PDF files1.Supplementary Information Supplementary Figures 1-11, Supplementary Methods and Supplementary References Excel files1

Galectin-8 Ameliorates Murine Autoimmune Ocular Pathology and Promotes a Regulatory T Cell Response

Galectins have emerged as potent immunoregulatory agents that control chronic inflammation through distinct mechanisms. Here, we report that treatment with Galectin-8 (Gal-8), a tandem-repeat member of the galectin family, reduces retinal pathology and prevents photoreceptor cell damage in a murine model of experimental autoimmune uveitis. Gal-8 treatment increased the number of...

Modulation of Ocular Surface Glycocalyx Barrier Function by a Galectin-3 N-terminal Deletion Mutant and Membrane-Anchored Synthetic Glycopolymers

Background Interaction of transmembrane mucins with the multivalent carbohydrate-binding protein galectin-3 is critical to maintaining the integrity of the ocular surface epithelial glycocalyx. This study aimed to determine whether disruption of galectin-3 multimerization and insertion of synthetic glycopolymers in the plasma membrane could be used to modulate glycocalyx barrier...

Clusterin Seals the Ocular Surface Barrier in Mouse Dry Eye

Dry eye is a common disorder caused by inadequate hydration of the ocular surface that results in disruption of barrier function. The homeostatic protein clusterin (CLU) is prominent at fluid-tissue interfaces throughout the body. CLU levels are reduced at the ocular surface in human inflammatory disorders that manifest as severe dry eye, as well as in a preclinical mouse model...

Galectin-8 Promotes Cytoskeletal Rearrangement in Trabecular Meshwork Cells through Activation of Rho Signaling

0 Noorjahan Panjwani 0 Kin-Sang Cho, Schepens Eye Research Institute, Harvard Medical School, United States of America 0 1 Program in Cell, Molecular & Developmental Biology, Sackler School of

Analysis of differential expression of glycosyltransferases in healing corneas by glycogene microarrays

It is generally accepted that the glycans on the cell surface and extracellular matrix proteins play a pivotal role in the events that mediate re-epithelialization of wounds. Yet, the global alteration in the structure and composition of glycans, specifically occuring during corneal wound closure remains unknown. In this study, GLYCOv2 glycogene microarray technology was used for...

The role of integrin glycosylation in galectin-8-mediated trabecular meshwork cell adhesion and spreading

Primary open angle glaucoma (POAG) is a major blindness-causing disease, characterized by elevated intraocular pressure due to an insufficient outflow of aqueous humor. The trabecular meshwork (TM) lining the aqueous outflow pathway modulates the aqueous outflow facility. TM cell adhesion, cell–matrix interactions, and factors that influence Rho signaling in TM cells are thought...