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Distributed analysis of interacting soil and structural systems under dynamic loading

Accurate, verifiable, and efficient analytical models for interacting soil and structure systems are still very challenging. While geotechnical software usually has limited capacity for structural analysis in the inelastic response range, the converse is true for structural analysis packages. In this paper, a multi-platform analytical approach is developed and verified. The...

An mRNA-specific tRNAi carrier eIF2A plays a pivotal role in cell proliferation under stress conditions: stress-resistant translation of c-Src mRNA is mediated by eIF2A

c-Src, a non-receptor protein tyrosine kinase, activates NF-κB and STAT3, which in turn triggers the transcription of anti-apoptosis- and cell cycle-related genes. c-Src protein regulates cell proliferation, cell motility and programmed cell death. And the elevated level of activated c-Src protein is related with solid tumor generation. Translation of c-Src mRNA is directed by an...

Antiangiogenic Effect of Ethanol Extract of Vigna angularis via Inhibition of Phosphorylation of VEGFR2, Erk, and Akt

, Republic of Korea Received 19 June 2015; Revised 3 August 2015; Accepted 4 August 2015 Academic Editor: Shun-Wan Chan Copyright © 2015 Oh Sung Kwon et al. This is an open access article distributed ... . Authors’ Contribution Oh Sung Kwon, Myoung Seok Jeong, and Bonglee Kim are co-first authors. Acknowledgment This work was supported by The Korea Science and Engineering Foundation (KOSEF) grant funded by

Antiangiogenic Effect of Ethanol Extract of Vigna angularis via Inhibition of Phosphorylation of VEGFR2, Erk, and Akt

, Republic of Korea Received 19 June 2015; Revised 3 August 2015; Accepted 4 August 2015 Academic Editor: Shun-Wan Chan Copyright © 2015 Oh Sung Kwon et al. This is an open access article distributed ... . Authors’ Contribution Oh Sung Kwon, Myoung Seok Jeong, and Bonglee Kim are co-first authors. Acknowledgment This work was supported by The Korea Science and Engineering Foundation (KOSEF) grant funded by

Prostate-specific extracellular vesicles as a novel biomarker in human prostate cancer

Extracellular vesicles (EVs) may play an important role in cancer development and progression. We aimed to investigate the prognostic potential of prostate-specific EVs in prostate cancer (PCa) patients. Plasma and prostate tissue were collected from patients who underwent surgery for PCa (n = 82) or benign prostatic hyperplasia (BPH, n = 28). To analyze the quantity of EVs in...

Blockage of the Ryanodine Receptor via Azumolene Does Not Prevent Mechanical Ventilation-Induced Diaphragm Atrophy

Mechanical ventilation (MV) is a life-saving intervention for patients in respiratory failure. However, prolonged MV causes the rapid development of diaphragm muscle atrophy, and diaphragmatic weakness may contribute to difficult weaning from MV. Therefore, developing a therapeutic countermeasure to protect against MV-induced diaphragmatic atrophy is important. MV-induced...

eIF4GI Facilitates the MicroRNA-Mediated Gene Silencing

MicroRNAs (miRNAs) are small noncoding RNAs that mediate post-transcriptional gene silencing by binding to complementary target mRNAs and recruiting the miRNA-containing ribonucleoprotein complexes to the mRNAs. However, the molecular basis of this silencing is unclear. Here, we show that human Ago2 associates with the cap-binding protein complex and this association is mediated...

Discovery of Cellular Proteins Required for the Early Steps of HCV Infection Using Integrative Genomics

Successful viral infection requires intimate communication between virus and host cell, a process that absolutely requires various host proteins. However, current efforts to discover novel host proteins as therapeutic targets for viral infection are difficult. Here, we developed an integrative-genomics approach to predict human genes involved in the early steps of hepatitis C...