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A comparison of different methods to handle missing data in the context of propensity score analysis

Propensity score analysis is a popular method to control for confounding in observational studies. A challenge in propensity methods is missing values in confounders. Several strategies for handling missing values exist, but guidance in choosing the best method is needed. In this simulation study, we compared four strategies of handling missing covariate values in propensity...

Effect modification, interaction and mediation: an overview of theoretical insights for clinical investigators [Corrigendum]

Effect modification, interaction and mediation: an overview of theoretical insights for clinical investigators [Corrigendum] Corraini P, Olsen M, Pedersen L, Dekkers OM, Vandenbroucke JP, Clin Epidemiol. 2017;9:331–338.On pages 333–334, the interaction contrast appeared incorrectly as 1.5 per 1,000 person-years, where it should read –1.5 per 1,000 person-years. This occurred from...

Endoscopic vs. microscopic transsphenoidal surgery for Cushing’s disease: a systematic review and meta-analysis

PurposeSystematic review and meta-analysis comparing endoscopic and microscopic transsphenoidal surgery for Cushing’s disease regarding surgical outcomes (remission, recurrence, and mortality) and complication rates. To stratify the results by tumor size.MethodsNine electronic databases were searched in February 2017 to identify potentially relevant articles. Cohort studies...

Effect modification, interaction and mediation: an overview of theoretical insights for clinical investigators

Effect modification, interaction and mediation: an overview of theoretical insights for clinical investigators Priscila Corraini,1 Morten Olsen,1 Lars Pedersen,1 Olaf M Dekkers,1,2 Jan P

Ribotype 078 Clostridium difficile infection incidence in Dutch hospitals is not associated with provincial pig farming: Results from a national sentinel surveillance, 2009-2015

. J. G. Sanders, Greetje A. Kam Methodology: Sofie M. van Dorp, Sabine C. de Greeff, Olaf M. Dekkers, Cornelis W. Knetsch, Project administration: Sofie M. van Dorp, CeÂline Harmanus. Software: Sofie ... . Writing ± review & editing: Sofie M. van Dorp, Sabine C. de Greeff, CeÂline Harmanus, Ingrid M. J. G. Sanders, Olaf M. Dekkers, Cornelis W. Knetsch, Greetje A. Kampinga, Daan W. Notermans, Ed J. Kuijper

Philosophy of Epidemiology

Epidemiology © The Author 2014. Published by Oxford University Press on behalf of the Johns Hopkins Bloomberg School of Public Health. All rights reserved. For permissions , please 2 Olaf M. Dekkers

An Outbreak of Clostridium difficile Ribotype 027 Associated with Length of Stay in the Intensive Care Unit and Use of Selective Decontamination of the Digestive Tract: A Case Control Study

Background An outbreak of Clostridium difficile ribotype 027 infection (CDI) occurred at an university hospital, involving 19 departments. To determine what hospital-associated factors drove the outbreak of this particular strain we performed a case-control study. Methods Cases (n = 79), diagnosed with CDI due to C. difficile ribotype 027 were matched for age and treating medical...

Insulin Resistance and Risk of Incident Cardiovascular Events in Adults without Diabetes: Meta-Analysis

Background Glucose, insulin and Homeostasis Model Assessment Insulin Resistance (HOMA-IR) are markers of insulin resistance. The objective of this study is to compare fasting glucose, fasting insulin concentrations and HOMA-IR in strength of association with incident cardiovascular disease. Methods We searched the PubMed, MEDLINE, EMBASE, Web of Science, ScienceDirect and...

Predicting Mortality in Patients with Diabetes Starting Dialysis

Background While some prediction models have been developed for diabetic populations, prediction rules for mortality in diabetic dialysis patients are still lacking. Therefore, the objective of this study was to identify predictors for 1-year mortality in diabetic dialysis patients and use these results to develop a prediction model. Methods Data were used from the Netherlands...

All-Cause and Disease-Specific Mortality in Hospitalized Patients With Clostridium difficile Infection: A Multicenter Cohort Study

Background. Mortality among patients with Clostridium difficile infection (CDI) is high. Because of high age and multiple underlying diseases, CDI-related mortality is difficult to estimate. We estimated CDI-related mortality in an endemic situation, not influenced by outbreaks and consequently certain patients and C. difficile strains. Methods. Between 2006 and 2009, 13 Dutch...

High Prevalence of Metabolic Syndrome Features in Patients Previously Treated for Nonfunctioning Pituitary Macroadenoma

funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Competing Interests: Olaf M. Dekkers is a PLOS ONE Editorial Board member. This

Infection with Soil-Transmitted Helminths Is Associated with Increased Insulin Sensitivity

Objective Given that helminth infections have been shown to improve insulin sensitivity in animal studies, which may be explained by beneficial effects on energy balance or by a shift in the immune system to an anti-inflammatory profile, we investigated whether soil-transmitted helminth (STH)-infected subjects are more insulin sensitive than STH-uninfected subjects. Design We...

Treatment Strategies and Survival of Older Breast Cancer Patients – An International Comparison between the Netherlands and Ireland

Objectives Forty percent of breast cancers occur among older patients. Unfortunately, there is a lack of evidence for treatment guidelines for older breast cancer patients. The aim of this study is to compare treatment strategy and relative survival for operable breast cancer in the elderly between The Netherlands and Ireland. Material and Methods From the Dutch and Irish...

Risk factors and outcomes after unplanned extubations on the ICU: a case-control study

Introduction Unplanned extubation (UE) is a frequent event during mechanical ventilation in critically ill patients and might be associated with increased morbidity and mortality. However, detailed knowledge of risk factors and outcomes after UE is lacking. Methods A case-control study was performed with a case to control ratio of 1:4. Incidence density sampling was applied...

Risk factors and outcomes after unplanned extubations on the ICU: a case-control study

Unplanned extubation (UE) is a frequent event during mechanical ventilation in critically ill patients and might be associated with increased morbidity and mortality. However, detailed knowledge of risk factors and outcomes after UE is lacking. A case-control study was performed with a case to control ratio of 1:4. Incidence density sampling was applied. Seventy-four cases and...

Survival in dialysis patients is not different between patients with diabetes as primary renal disease and patients with diabetes as a co-morbid condition

Background On dialysis, survival among patients with diabetes mellitus is inferior to survival of non-diabetic patients. We hypothesized that patients with diabetes as primary renal disease have worse survival compared to patients with diabetes as a co-morbid condition and aimed to compare all-cause mortality between these patient groups. Methods Data were collected from the...

Survival in dialysis patients is not different between patients with diabetes as primary renal disease and patients with diabetes as a co-morbid condition

On dialysis, survival among patients with diabetes mellitus is inferior to survival of non-diabetic patients. We hypothesized that patients with diabetes as primary renal disease have worse survival compared to patients with diabetes as a co-morbid condition and aimed to compare all-cause mortality between these patient groups. Data were collected from the Netherlands Cooperative...

All That Glitters Isn't Gold: A Survey on Acknowledgment of Limitations in Biomedical Studies

A. Akl Lizzy Brewster Olaf M. Dekkers Ingrid Mu hlhauser Bernd Richter Sonal Singh Steven Goodman Milo A. Puhan Christos A. Ouzounis, The Centre for Research and Technology, Hellas, Greece Background