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The significance of selected tree species age in their efficiency in elements phytoextraction from wastes mixture

The phytoextraction of toxic elements present in industrial wastes by selected tree species seems to offer an interesting alternative to hyperaccumulators, which are generally highly effective but small. For this reason, the study aimed to compare the potential of 1- and 2-year-old Tilia cordata Miller and Ulmus laevis Pall seedlings growing on a mixture of wastes (flotation...

Diversity of low-molecular weight organic acids synthesized by Salix growing in soils characterized by different Cu, Pb and Zn concentrations

The aim of the study was to evaluate the biosynthesis and exudation of 10 low-molecular weight organic acids (LMWOAs) into the rhizosphere with a simultaneous analysis of the acid contents in the roots and leaves of 9 Salix taxa growing on two experimental areas, differing in their concentrations of copper (Cu), lead (Pb) and zinc (Zn) in the soil (Area 1—low, Area 2—high...

HES factors regulate specific aspects of chondrogenesis and chondrocyte hypertrophy during cartilage development

RBPjκ-dependent Notch signaling regulates multiple processes during cartilage development, including chondrogenesis, chondrocyte hypertrophy and cartilage matrix catabolism. Select members of the HES- and HEY-families of transcription factors are recognized Notch signaling targets that mediate specific aspects of Notch function during development. However, whether particular HES...

Thermal stability and conductivity of hot-pressed Si3N4–graphene composites

P. Rutkowski 0 L. Stobierski 0 G. Gorny 0 0 P. Rutkowski (&) L. Stobierski G. Gorny Department of Ceramics and Refractories, Faculty of Materials Science and Ceramics, AGH University of Science and

Miejsce menedżera produktu w nowoczesnych strukturach organizacyjnych w procesach zarządzania produktem


Anisotropy of elastic properties and thermal conductivity of Al2O3/h-BN composites

, Krakow, Poland 1 P. Rutkowski (&) W. Piekarczyk L. Stobierski G. Gorny Department of Ceramics and Refractories, Faculty of Materials Science and Ceramics, AGH University of Science and Technology , Krakow

Effect of nivolumab on health-related quality of life in patients with treatment-naïve advanced melanoma: results from the phase III CheckMate 066 study

C. Robert 7 J. C. Hassel 6 P. Rutkowski 5 K. J. Savage 4 F. Taylor 9 C. Coon 9 I. Gilloteau 8 H. B. Dastani 8 I. M. Waxman 8 A. P. Abernethy 2 0 Istituto Nazionale Tumori Fondazione Pascale , Napoli

Prospective assessment of a gene signature potentially predictive of clinical benefit in metastatic melanoma patients following MAGE-A3 immunotherapeutic (PREDICT)

. Ascierto 9 M. Maio 16 J.-J. Grob 15 P. Murawa 14 B. Dreno 13 M. Ross 18 J. Weber 17 A. Hauschild 12 P. Rutkowski 7 A. Testori 8 E. Levchenko 5 A. Enk 6 L. Misery 2 C. Vanden Abeele 3 I. Vojtek 3 O. Peeters 0

Patient perception of the benefit of a BRAF inhibitor in metastatic melanoma: quality-of-life analyses of the BREAK-3 study comparing dabrafenib with dacarbazine

Background In a randomized phase III study (BREAK-3), dabrafenib showed prolonged progression-free survival (PFS) (median 5.1 versus 2.7 months; hazard ratio = 0.30; 95% confidence interval 0.18–0.53; P < 0.0001) compared with dacarbazine (DTIC) in patients with BRAF V600E metastatic melanoma. Assessing how these results are transformed into a real health benefit for patients is...

Phase III study of nilotinib versus best supportive care with or without a TKI in patients with gastrointestinal stromal tumors resistant to or intolerant of imatinib and sunitinib

Background This phase III open-label trial investigated the efficacy of nilotinib in patients with advanced gastrointestinal stromal tumors following prior imatinib and sunitinib failure.

Surgery and radiotherapy in the treatment of cutaneous melanoma

Adequate surgical management of primary melanoma and regional lymph node metastasis, and rarely distant metastasis, is the only established curative treatment. Surgical management of primary melanomas consists of excisions with 1–2 cm margins and primary closure. The recommended method of biopsy is excisional biopsy with a 2 mm margin and a small amount of subcutaneous fat. In...

Functional and symptom impact of trametinib versus chemotherapy in BRAF V600E advanced or metastatic melanoma: quality-of-life analyses of the METRIC study

Background In a randomized phase III study, trametinib prolonged progression-free survival and improved overall survival versus chemotherapy in patients with BRAF V600 mutation-positive melanoma.

Prognostic value of KIT/PDGFRA mutations in gastrointestinal stromal tumours (GIST): Polish Clinical GIST Registry experience

A. Wozniak E-mail: P. Rutkowski A. Piskorz M. Ciwoniuk C. Osuch E. Bylina J. Sygut M. Chosia J. Rys K. Urbanczyk W. Kruszewski P. Sowa J. Siedlecki M. Debiec-Rychter J. Limon on behalf of Polish

MiR-17-92 and miR-221/222 cluster members target KIT and ETV1 in human gastrointestinal stromal tumours

Background:Gastrointestinal stromal tumours (GIST) are characterised by high expression of KIT and ETV1, which cooperate in GIST oncogenesis. Our aim was to identify microRNAs that are deregulated in GIST, have a role in GIST pathogenesis, and could potentially be used as therapeutic tool.Methods:Differentially expressed microRNAs between primary GIST (n=50) and gastrointestinal...

—to: Rippin JD, Patel A, Belyaev ND, Gill GV, Barnett AH, Bain SC (2003) Nitric oxide synthase gene polymorphisms and diabetic nephropathy. Diabetologia 46:426–428

0 M. J. Zychma, J. Gumprecht, P. Rutkowski, W. Grzeszczak Department of Internal Medicine , Diabetology and Nephrolo- gy, Silesian School of Medicine , Zabrze, Poland To the Editor: Regarding Dr

Miscanthus × Giganteus straw and pellets as sustainable fuels and raw material for activated carbon

Miscanthus × Giganteus is an excellent candidate for energy cultivation. Here we report, for the first time, the results of the pyrolysis of Miscanthus × Giganteus straw or pellets both in tubular reactor (3–6 g) and in rotary kiln (10–30 g). At 400–600°C the fractions obtained from both reactors are: solid 16–25 (wt.%); liquids 25–40; water 15–20 and gases 15–50. GC-MS analyses...

Alterations of routine blood tests in adult patients with soft tissue sarcomas: Relationships to cytokine serum levels and prognostic significance

. Sklodowska-Curie Memorial Cancer Center and Institute oj Oncologv Warsaw , Poland 1 Abbreviation. NS - not significant 2 P. Rutkowski, MD M. Sklodowska-Curie Memorial Cancer Center and Institute of Oncology

Guidelines for time-to-event end point definitions in sarcomas and gastrointestinal stromal tumors (GIST) trials: results of the DATECAN initiative (Definition for the Assessment of Time-to-event Endpoints in CANcer trials)†

Background The use of potential surrogate end points for overall survival, such as disease-free survival (DFS) or time-to-treatment failure (TTF) is increasingly common in randomized controlled trials (RCTs) in cancer. However, the definition of time-to-event (TTE) end points is rarely precise and lacks uniformity across trials. End point definition can impact trial results by...

IS3. Gastric Cancer

Background The highest rates of gastric cancer occur in Eastern Asia. Fluoropyrimidine-based therapy is used initially in unresectable and metastatic disease, following progression, 60–70% of patients in Asian countries subsequently receive second-line chemotherapy. However, there is no standard treatment in this setting. Ixabepilone, an epothilone B analog, is a non-taxane...