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Validation of clinical control in COPD as a new tool for optimizing treatment

Validation of clinical control in COPD as a new tool for optimizing treatment Juan José Soler-Cataluña,1,2 Maribel Marzo,3 Pablo Catalán,1 Cristina Miralles,1 Bernardino Alcazar,2,4 Marc

toyLIFE: a computational framework to study the multi-level organisation of the genotype-phenotype map

The genotype-phenotype map is an essential object to understand organismal complexity and adaptability. However, its experimental characterisation is a daunting task. Thus, simple models have been proposed and investigated. They have revealed that genotypes differ in their robustness to mutations; phenotypes are represented by a broadly varying number of genotypes, and simple...