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Total brachial artery reactivity and first time incident coronary heart disease events in a longitudinal cohort study: The multi-ethnic study of atherosclerosis

. Conceptualization: Joseph F. Polak, Pamela Ouyang, Dhananjay Vaidya. Investigation: Joseph F. Polak, Pamela Ouyang, Dhananjay Vaidya. Methodology: Joseph F. Polak, Pamela Ouyang, Dhananjay Vaidya. Project ... administration: Joseph F. Polak. Supervision: Joseph F. Polak. Validation: Joseph F. Polak. Writing ? original draft: Joseph F. Polak. Writing ? review & editing: Pamela Ouyang, Dhananjay Vaidya. 17 / 20 18

The Sex and Race Specific Relationship between Anthropometry and Body Fat Composition Determined from Computed Tomography: Evidence from the Multi-Ethnic Study of Atherosclerosis

Background Few studies have investigated the relationship of anthropometric measurements with computed tomography (CT) body fat composition, and even fewer determined if these relationships differ by sex and race. Methods CT scans from 1,851 participants in the population based Multi-Ethnic Study of Atherosclerosis were assessed for visceral and subcutaneous fat areas by semi...

Sex Differences in Diabetes and Risk of Incident Coronary Artery Disease in Healthy Young and Middle-Aged Adults

OBJECTIVE Controversy exists about the coronary artery disease (CAD) risk conveyed by diabetes in young and middle-aged women. We investigated sex differences in CAD by diabetes status among healthy individuals with different underlying risks of heart disease.

Progression of coronary artery atherosclerosis in rheumatoid arthritis: comparison with participants from the Multi-Ethnic Study of Atherosclerosis

Introduction In cross-sectional studies, patients with rheumatoid arthritis (RA) have higher coronary artery calcium (CAC) than controls. However, their rate of progression of CAC and the predictors of CAC progression have heretofore remained unknown. Methods Incidence and progression of CAC were compared in 155 patients with RA and 835 control participants. The association of...

Sex-Steroid Hormones and Electrocardiographic QT-Interval Duration: Findings From the Third National Health and Nutrition Examination Survey and the Multi-Ethnic Study of Atherosclerosis

Zhang, Wendy S. Post, Elena Blasco-Colmenares, Eliseo Guallar); Division of Cardiology, Department of Medicine, School of Medicine, Johns Hopkins University, Baltimore, Maryland (Pamela Ouyang, Wendy S

Fatness and fitness: how do they influence health-related quality of life in type 2 diabetes mellitus?

Objective We examined whether adiposity and fitness explain the decrease in health-related quality of life (HRQOL) associated with type 2 diabetes mellitus. Methods This was a cross-sectional study using baseline data from two exercise training interventions. One study enrolled people with and the other without type 2 diabetes. We assessed aerobic fitness ("fitness") as peak...

Low-Risk Lifestyle, Coronary Calcium, Cardiovascular Events, and Mortality: Results From MESA

Christopher T. Sibley 0 Pamela Ouyang 0 Roger S. Blumenthal 0 0 Baltimore , MD 21287 ( Unhealthy lifestyle habits are a major contributor to coronary artery disease. The purpose of the present study was to ... Clinical Center, Bethesda, Maryland (Christopher T. Sibley); and Johns Hopkins Bayview Medical Center, Johns Hopkins University, Baltimore, Maryland (Pamela Ouyang). This work was supported by the National

Defining the Metabolic Syndrome Construct: Multi-Ethnic Study of Atherosclerosis (MESA) cross-sectional analysis

DHANANJAY VAIDYA MBBS PHD MOYSES SZKLO DRPH KIANG LIU PHD PAMELA J. SCHREINER PHD ALAIN G. BERTONI PHD PAMELA OUYANG C a r d i o v a s c u l a r a n d OBJECTIVE - It is controversial whether the

Inflammation and the Incidence of Type 2 Diabetes: The Multi-Ethnic Study of Atherosclerosis (MESA)

ALAIN G. BERTONI GREGORY L. BURKE MSC JAMES A. OWUSU MERCEDES R. CARNETHON PHD DHANANJAY VAIDYA PHD R. GRAHAM BARR DRPH NANCY S. JENNY PHD PAMELA OUYANG MBBS JEROME I. ROTTER E p i d e m i o l o g y

Relationship of Metabolic Syndrome With Incident Aortic Valve Calcium and Aortic Valve Calcium Progression: The Multi-Ethnic Study of Atherosclerosis (MESA)*

Ronit Katz Matthew J. Budoff Junichiro Takasu David M. Shavelle Alain Bertoni Roger S. Blumenthal Pamela Ouyang Nathan D. Wong Kevin D. O'Brien OBJECTIVEMetabolic syndrome (MetS) has been associated

Association of Endogenous Sex Hormones With Diabetes andImpaired Fasting Glucose in Men: Multi-Ethnic Study of Atherosclerosis*

LAURA A. COLANGELO MS PAMELA OUYANG KIANG LIU PHD PETER KOPP SHERITA HILL GOLDEN ADRIAN S. DOBS MHS MOYSES SZKLO DRPH DHANANJAY VAIDYA PHD MARY CUSHMAN SUSAN M. GAPSTUR PHD E p i d e m i o l o g y

Association of Coronary Artery and Aortic Calcium With Lumbar Bone Density: The MESA Abdominal Aortic Calcium Study

The MESA Abdominal Aortic Calcium Study Joseph A. Hyder ) Matthew A. Allison Nathan Wong Agnes Papa Thomas F. Lang Claude Sirlin Susan M. Gapstur Pamela Ouyang J. Jeffrey Carr Michael H. Criqui ... , Illinois (Susan Gapstur); Division of Cardiology, School of Medicine, Johns Hopkins University, Baltimore, Maryland (Pamela Ouyang); Departments of Radiology and Public Health Sciences, School of Medicine

The Effect of Vitamin Therapy on the Progression of Coronary Artery Atherosclerosis Varies by Haptoglobin Type in Postmenopausal Women

OBJECTIVE—Antioxidant trials have not demonstrated efficacy in slowing cardiovascular disease but could not rule out benefit for specific patient subgroups. Antioxidant therapy reduces LDL oxidizability in haptoglobin 1 allele homozygotes (Hp 1-1), but not in individuals with the haptoglobin 2 allele (Hp 2-1 or Hp 2-2). We therefore hypothesized that haptoglobin type would be...

A Genome-Wide Association Meta-Analysis of Circulating Sex Hormone–Binding Globulin Reveals Multiple Loci Implicated in Sex Steroid Hormone Regulation

Sex hormone-binding globulin (SHBG) is a glycoprotein responsible for the transport and biologic availability of sex steroid hormones, primarily testosterone and estradiol. SHBG has been associated with chronic diseases including type 2 diabetes (T2D) and with hormone-sensitive cancers such as breast and prostate cancer. We performed a genome-wide association study (GWAS) meta...