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26 papers found.
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Iα to Iβ mechano-conversion and amorphization in native cellulose simulated by crystal bending

The bending of rod-like native cellulose crystals with degree of polymerization 40 and 160 using molecular dynamics simulations resulted in a deformation-induced local amorphization at the kinking point and allomorphic interconversion between cellulose Iα and Iβ in the unbent segments. The transformation mechanism involves a longitudinal chain slippage of the hydrogen-bonded...

NEAT1_2—SFPQ axis mediates cisplatin resistance in liver cancer cells in vitro

NEAT1-2-SFPQ axis mediates cisplatin resistance in liver cancer cells in vitro Yi Ru,1–4 Xiao-Jie Chen,5 Wen-Zhi Guo,1–4 She-Gan Gao,5 Yi-Jun Qi,5 Pan Chen,5 Xiao-Shan Feng,5 Shui-Jun Zhang1–4 1Henan

The J-curve Association between Systolic Blood Pressure and Clinical Outcomes in Ischemic Stroke or TIA: The BOSS Study

We aimed to assess the association between systolic blood pressure (SBP) and clinical outcome in 2,397 ischemic stroke (IS) or transient ischemic attack (TIA) patients from the Blood Pressure and Clinical Outcome in TIA or Ischemic Stroke (BOSS) study. BOSS study was a hospital-based, prospective cohort study. The SBP was defined as mean value of 90 days self-measured SBP after...

On The Lash Bar Count Algorithm Based on Image Recognition

This paper solved the problem that lash bars were difficult to be quickly and accurately counted,and proposed a kind of lash bar count algorithm based on image recognition through observation and study of the morphology of lash bars, namely the algorithm that combines cross type algorithm and flexible T type algorithm. Firstly,the color image is processed by graying and threshold...

Extreme obesity induces massive beta cell expansion in mice through self-renewal and does not alter the beta cell lineage

Aims/hypothesis Understanding the developmental biology of beta cell regeneration is critical for developing new diabetes therapies. Obesity is a potent but poorly understood stimulus for beta cell expansion. Current models of obesity are complicated by developmental compensation or concurrent diabetes, limiting their usefulness for identifying the lineage mechanism(s) of beta...

Serotonin-Exacerbated DSS-Induced Colitis Is Associated with Increase in MMP-3 and MMP-9 Expression in the Mouse Colon

Background. 5-HT enhances dextran sulfate sodium- (DSS-) induced colitis and is involved in inflammatory bowel disease (IBD). Matrix metalloproteinases (MMPs) play roles in the process of intestinal inflammation. Aims. To examine whether 5-HT induces MMPs expression in mouse colon to enhance DSS-induced colitis. Materials and Methods. C57BL/6J (B6) mice were treated with either...

A Non-sulfided flower-like Ni-PTA Catalyst that Enhances the Hydrotreatment Efficiency of Plant Oil to Produce Green Diesel

performance in the hydrotreatment of Jatropha oil (autoclave was drawn by Pan Chen). Full size image Characterization of flower-like Ni-PTA catalyst The morphology of the catalyst was characterized by ... of Lignocellulosic Chemistry, Beijing Forestry University, Beijing 100083, P. R. ChinaJing Liu, Pan Chen, Lihong Deng, Jing He, Luying Wang & Jiandu LeiKey Laboratory for Biomechanics and

NiO-PTA supported on ZIF-8 as a highly effective catalyst for hydrocracking of Jatropha oil

, Luying Wang, Rong Li, Pan Chen, Xin Rao, Lihong Deng & Jiandu LeiKey Laboratory for Biomechanics and Mechanobiology of Ministry of Education, School of Biological Science and Medical Engineering, Beihang ... for Luying Wang in:Nature Research journals • PubMed • Google ScholarSearch for Rong Li in:Nature Research journals • PubMed • Google ScholarSearch for Pan Chen in:Nature Research journals • PubMed

Short-Fragment DNA Residue from Vaccine Purification Processes Promotes Immune Response to the New Inactivated EV71 Vaccine by Upregulating TLR9 mRNA

To reduce potential oncogenic long genomic DNA in vaccines, nuclease treatment has been applied in the purification processes. However, this action increased the residue of short-fragment DNA and its effect on vaccine potency was still elusive. In this study, we found residual sf-DNA in an inactivated EV71 vaccine could enhance humoral immune response in mice. Ag stimulation in...

Comparing the Primary and Recall Immune Response Induced by a New EV71 Vaccine Using Systems Biology Approaches

Three inactivated EV71 whole-virus vaccines have completed Phase III clinical trials in mainland China, with high efficacy, satisfactory safety, and sustained immunogenicity. However, the molecular mechanisms how this new vaccine elicit potent immune response remain poorly understood. To characterize the primary and recall responses to EV71 vaccines, PBMC from 19 recipients...

The use of targeted exome sequencing in genetic diagnosis of young patients with severe hypercholesterolemia

Familial hypercholesterolemia (FH) is an autosomal dominant disorder. Although genetic testing is an important tool for detecting FH-causing mutations in patients, diagnostic methods for young patients with severe hypercholesterolemia are understudied. This study compares the target exome sequencing (TES) technique with the DNA resequencing array technique on young patients with...

The Gastric Mucosa from Patients Infected with CagA+ or VacA+ Helicobacter pylori Has a Lower Level of Dual Oxidase-2 Expression than Uninfected or Infected with CagA−/VacA− H. pylori

Background Helicobacter pylori (H. pylori) is a well-recognized gastroduodenal pathogen and class I carcinogen. Dual oxidase-2 (DUOX2), a member of NADPH oxidase family, has several critical physiological functions, including thyroid hormone biosynthesis and host mucosal defense.AimTo investigate the effect of H. pylori infection on DUOX2 gene expression in human stomach...

Lactoferrin suppresses the Epstein–Barr virus-induced inflammatory response by interfering with pattern recognition of TLR2 and TLR9

, Ministry of Education, Changsha, ChinaYing Zheng, Zailong Qin, Qiurong Ye, Pan Chen, Zhaohui Luo, Xiaoping Liu, Yanhong Zhou, Wei Xiong, Jian Ma & Guiyuan LiCenter for Medical Research, Second Xiangya ... • Google ScholarSearch for Zailong Qin in:Nature Research journals • PubMed • Google ScholarSearch for Qiurong Ye in:Nature Research journals • PubMed • Google ScholarSearch for Pan Chen in:Nature Research

TorsinA rescues ER-associated stress and locomotive defects in C. elegans models of ALS

Molecular mechanisms underlying neurodegenerative diseases converge at the interface of pathways impacting cellular stress, protein homeostasis and aging. Targeting the intrinsic capacities of neuroprotective proteins to restore neuronal function and/or attenuate degeneration represents a potential means toward therapeutic intervention. The product of the human DYT1 gene, torsinA...

Complete Genome Analysis of a Haemophilus parasuis Serovar 12 Strain from China

Haemophilus parasuis is the etiological agent of Glässer's disease in pigs and 15 standard serovars were identified. The widespread disease causes great economic loss in the swine industry worldwide. Aiming to investigate the differences in genome composition and functions among various strains, a highly virulent strain ZJ0906 of H. parasuis serovar 12 from China was analyzed and...

Development and Evaluation of a Pseudovirus-Luciferase Assay for Rapid and Quantitative Detection of Neutralizing Antibodies against Enterovirus 71

The level of neutralizing antibodies (NtAb) induced by vaccine inoculation is an important endpoint to evaluate the efficacy of EV71 vaccine. In order to evaluate the efficacy of EV71 vaccine, here, we reported the development of a novel pseudovirus system expression firefly luciferase (PVLA) for the quantitative measurement of NtAb. We first evaluated and validated the...

SPLUNC1 Regulates Cell Progression and Apoptosis through the miR-141-PTEN/p27 Pathway, but Is Hindered by LMP1

Chen Xiaofang Guo Houde Zhou Wenling Zhang Zhaoyang Zeng Qianjin Liao Xiayu Li Bo Xiang Jianbo Yang Jian Ma Ming Zhou Shuping Peng Juanjuan Xiang Xiaoling Li Colvin Wanshura LE Wei Xiong James B

Sodium taurocholate cotransporting polypeptide is a functional receptor for human hepatitis B and D virus

Human hepatitis B virus (HBV) infection and HBV-related diseases remain a major public health problem. Individuals coinfected with its satellite hepatitis D virus (HDV) have more severe disease. Cellular entry of both viruses is mediated by HBV envelope proteins. The pre-S1 domain of the large envelope protein is a key determinant for receptor(s) binding. However, the identity of...