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15 papers found.
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Molecular imaging of multiple sclerosis: from the clinical demand to novel radiotracers

BackgroundBrain PET imaging with different tracers is mainly clinically used in the field of neurodegenerative diseases and brain tumors. In recent years, the potential usefulness of PET has also gained attention in the field of MS. In fact, MS is a complex disease and several processes can be selected as a target for PET imaging. The use of PET with several different tracers has...

Enlarged Virchow Robin spaces associate with cognitive decline in multiple sclerosis

: Alice Favaretto, Andrea Lazzarotto, Stefano Pravato, Monica Margoni, Paolo Gallo. Data curation: Alice Favaretto, Andrea Lazzarotto, Stefano Pravato, Paolo Gallo. Formal analysis: Dario Seppi, Davide ... Poggiali, Paolo Gallo. Investigation: Alice Favaretto, Andrea Lazzarotto, Alice Riccardi, Stefano Pravato, Francesco Causin, Maria Giulia Anglani, Paolo Gallo. Methodology: Alice Favaretto, Andrea

Trans-synaptic degeneration in the optic pathway. A study in clinically isolated syndrome and early relapsing-remitting multiple sclerosis with or without optic neuritis

, Lisa Federle, Davide Poggiali, Silvia Miante, Elisabetta Pilotto, Francesca Rinaldi, Paola Perini, Maria Pia Sormani, Edoardo Midena, Paolo Gallo. Data curation: Marco Puthenparampil, Lisa Federle ... , Davide Poggiali, Silvia Miante, Alessio Signori, Elisabetta Pilotto. Formal analysis: Marco Puthenparampil, Lisa Federle, Elisabetta Pilotto, Francesca Rinaldi. Funding acquisition: Paolo Gallo

Combining Genetic Variants to Improve Risk Prediction for NAFLD and Its Progression to Cirrhosis: A Proof of Concept Study

Andrea Baiocchini,2 Marco Delle Monache,3 Roberto Cecere,3 Adriano Maria Pellicelli,4 Valerio Giannelli,4 Simone Carotti,5 Giovanni Galati,1 Paolo Gallo,1 Francesco Valentini,1 Franca Del Nonno,2 Davide

Efficacy of fingolimod and interferon beta-1b on cognitive, MRI, and clinical outcomes in relapsing–remitting multiple sclerosis: an 18-month, open-label, rater-blinded, randomised, multicentre study (the GOLDEN study)

Cognitive impairment (CI) affects 40–65% of multiple sclerosis (MS) patients. This study attempted evaluating the effects of fingolimod and interferon beta-1b (IFN β-1b) on CI progression, magnetic resonance imaging (MRI) and clinical outcomes in relapsing–remitting MS (RRMS) patients over 18 months. The GOLDEN study was a pilot study including RRMS patients with CI randomised (2...

The Parallel Analysis of Phase Sensitive Inversion Recovery (PSIR) and Double Inversion Recovery (DIR) Images Significantly Improves the Detection of Cortical Lesions in Multiple Sclerosis (MS) since Clinical Onset

. Francesco Causin has nothing to disclose. Prof. Paolo Gallo has received honoraria from Bayer Schering, Biogen Idec/Elan, Merck Serono, Novartis, Sanofi-Aventis and Teva; has been a consultant for Bayer

Disease-Modifying Drugs Reduce Cortical Lesion Accumulation and Atrophy Progression in Relapsing-Remitting Multiple Sclerosis: Results from a 48-Month Extension Study

, Matteo Atzori, Alice Favaretto, Dario Seppi, and Paolo Gallo Multiple Sclerosis Centre, Department of Neuroscience SNPSRR, University Hospital of Padova, Via Giustiniani 5, 35128 Padova, Italy Received ... , Teva, and Merck Serono. Paolo Gallo has received speaker fees and travel expenses from Biogen Idec, Merck Serono, Bayer Schering, Genzyme, Novartis, and Sanofi-Aventis. Acknowledgments This study was

Natalizumab in the pediatric MS population: results of the Italian registry

Background Natalizumab is a promising option for pediatric multiple sclerosis (MS) patients with active evolution and a poor response to Interferon-beta or Glatiramer Acetate. However, no data are available in large cohorts of patients and after a long-term follow up. Our study was planned to shed lights on this topic. Methods A registry was established in 2007 in Italy to...

Breath-print analysis by e-nose for classifying and monitoring chronic liver disease: a proof-of-concept study

Giovanni Galati Paolo Gallo Chiara Vernile Claudio Pedone Raffaele?Antonelli?Incalzi Antonio Picardi Since the liver plays a key metabolic role, volatile organic compounds in the exhaled breath might change

Coexistence of HBsAg and HBsAb in a difficult-to-treat chronic hepatitis B: loss of HBsAg with entecavir plus tenofovir combination

Background Some reports have documented the coexistence of Hepatitis B surfage Antigen (HBsAg) and anti-HBsAg antibodies (HBsAb) in patients with chronic hepatitis B (CHB), often in the absence of amino acid substitutions in the HBsAg sequences of the Hepatitis B Virus (HBV) genome able to explain an immunological escape variant. HBV genome has a very compact coding organization...

Lysosomal Acid Lipase Activity Is Reduced Both in Cryptogenic Cirrhosis and in Cirrhosis of Known Etiology

Lysosomal acid lipase deficiency (LAL-d) is a rare autosomal recessive disease in which LAL activity is almost absent, with consequent massive microvesicular steatosis evolving to cirrhosis and liver failure. We aimed to determine LAL-activity, and to investigate the most common single nucleotide polymorphism (SNP) affecting the LIPA gene and responsible for 50–70% of LAL-d cases...

Anatomical Correlates of Cognitive Functions in Early Parkinson's Disease Patients

Background Cognitive deficits may occur early in Parkinson's disease (PD) but the extent of cortical involvement associated with cognitive dysfunction needs additional investigations. The aim of our study is to identify the anatomical pattern of cortical thickness alterations in patients with early stage PD and its relationship with cognitive disability. Methods We recruited 29...

Cortical Pathology in RRMS: Taking a Cue from Four Sisters

Background. Although grey matter pathology is a relevant aspect of multiple sclerosis (MS) both with physical and cognitive rebounds, its pathogenesis is still under investigation. To what extent the familial and sporadic cases of MS differ in cortical pathology has not been elucidated yet. Here we present a multiple case report of four sisters affected by MS, all of them having...

Modeling the Distribution of New MRI Cortical Lesions in Multiple Sclerosis Longitudinal Studies

Objective Recent studies have shown the relevance of the cerebral grey matter involvement in multiple sclerosis (MS). The number of new cortical lesions (CLs), detected by specific MRI sequences, has the potential to become a new research outcome in longitudinal MS studies. Aim of this study is to define the statistical model better describing the distribution of new CLs...

Neurofunctional Modulation of Brain Regions by the Observation of Pointing and Grasping Actions

Previous neuroimaging research on healthy humans has provided evidence for a neural system underlying the observation of another person's hand actions. However, whether the neural processes involved in this capacity are activated by the observation of other transitive hand actions such as pointing remains unknown. Therefore, using functional magnetic resonance imaging we...