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Expression of Ik6 and Ik8 Isoforms and Their Association with Relapse and Death in Mexican Children with Acute Lymphoblastic Leukemia

Expression of the 6 and 8 dominant-negative Ikaros isoforms in pediatric patients with acute lymphoblastic leukemia has been associated with a high risk of relapse and death; due to these isoforms disrupting the differentiation and proliferation of lymphoid cells. The aim of this study was to know the frequency of Ik6 and Ik8 in 113 Mexican ALL-children treated within the...

Signaling Proteins and Transcription Factors in Normal and Malignant Early B Cell Development

, 06720 México, DF, Mexico Received 11 March 2011; Accepted 8 April 2011 Academic Editor: Philip L. McCarthy Copyright © 2011 Patricia Pérez-Vera et al. This is an open access article distributed under