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Search: authors:"Patrick M. Long"

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Acetate Supplementation Induces Growth Arrest of NG2/PDGFRα-Positive Oligodendroglioma-Derived Tumor-Initiating Cells

Cancer is associated with globally hypoacetylated chromatin and considerable attention has recently been focused on epigenetic therapies. N-acetyl-L-aspartate (NAA), the primary storage form of acetate in the brain, and aspartoacylase (ASPA), the enzyme responsible for NAA catalysis to generate acetate and ultimately acetyl-Coenzyme A for histone acetylation, are reduced in...

Cell Biology and Signaling

EXPRESSION IN NEUROBLASTOMA Patrick M. Long 8 Schepens Eye Research Institute 9 University of Texas Southwestern Medical Center 10 University of Pittsburgh 11 CB-16. SHP-2/PTPN11 IS A CRITICAL MEDIATOR OF