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24 papers found.
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Using distant supervision to augment manually annotated data for relation extraction

Conceptualization: Gang Li, K. Vijay-Shanker. Data curation: Peng Su, Gang Li. Formal analysis: Peng Su, K. Vijay-Shanker. Funding acquisition: Cathy Wu, K. Vijay-Shanker. Methodology: Peng Su, Gang Li, K. Vijay ... -Shanker. Software: Peng Su, Gang Li. Writing ? original draft: Peng Su, Cathy Wu, K. Vijay-Shanker. Writing ? review & editing: Peng Su, Gang Li, Cathy Wu, K. Vijay-Shanker. 15 / 17 10. 11. Peng Y, Gupta

CUL4B promotes prostate cancer progression by forming positive feedback loop with SOX4

How to distinguish indolent from aggressive disease remains a great challenge in prostate cancer (PCa) management. Cullin 4B (CUL4B) is a scaffold protein and exhibits oncogenic activity in a variety of human malignancies. In this study, we utilized PCa tissue specimens, cell lines and xenograft models to determine whether CUL4B contributes to PCa progression and metastasis. Here...

Hyperbaric oxygen treatment of spinal cord injury in rat model

The purpose of this study was to investigate the therapeutic effects and mechanisms of hyperbaric oxygen (HBO) treatment on rats following spinal cord injury (SCI). A total of 45 Sprague-Dawley (SD) rats were randomly divided into three groups. Sham-SCI group was surgically exposed but not subjected to the SCI procedure. SCI-control group was administered SCI and treated with...

A Novel Gene RNF138 Expressed in Human Gliomas and Its Function in the Glioma Cell Line U251

Background: The gliomas represent the most common primary malignant brain tumors; however, little is known about the molecular pathogenesis of these tumors. Recent research reveals that the oncogenesis and development of gliomas have a close relation to the overexpression of several oncogenes and the inactivation of tumor suppressor genes. Whether the RING finger protein, RNF138...

A Novel Gene RNF138 Expressed in Human Gliomas and Its Function in the Glioma Cell Line U251

Background: The gliomas represent the most common primary malignant brain tumors; however, little is known about the molecular pathogenesis of these tumors. Recent research reveals that the oncogenesis and development of gliomas have a close relation to the overexpression of several oncogenes and the inactivation of tumor suppressor genes. Whether the RING finger protein, RNF138...

A New Approach for Resolving Conflicts in Actionable Behavioral Rules

Received 7 April 2014; Accepted 29 April 2014; Published 5 August 2014 Academic Editor: Zheng Xu Copyright © 2014 Peng Su et al. This is an open access article distributed under the Creative Commons

A New Approach for Resolving Conflicts in Actionable Behavioral Rules

Received 7 April 2014; Accepted 29 April 2014; Published 5 August 2014 Academic Editor: Zheng Xu Copyright © 2014 Peng Su et al. This is an open access article distributed under the Creative Commons

Identification of the Key Genes and Pathways in Esophageal Carcinoma

Copyright © 2016 Peng Su et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium

Identification of the Key Genes and Pathways in Esophageal Carcinoma

Copyright © 2016 Peng Su et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium

Design and Analysis of Tubular Permanent Magnet Linear Wave Generator

Due to the lack of mature design program for the tubular permanent magnet linear wave generator (TPMLWG) and poor sinusoidal characteristics of the air gap flux density for the traditional surface-mounted TPMLWG, a design method and a new secondary structure of TPMLWG are proposed. An equivalent mathematical model of TPMLWG is established to adopt the transformation relationship...

Design and Analysis of Tubular Permanent Magnet Linear Wave Generator

Due to the lack of mature design program for the tubular permanent magnet linear wave generator (TPMLWG) and poor sinusoidal characteristics of the air gap flux density for the traditional surface-mounted TPMLWG, a design method and a new secondary structure of TPMLWG are proposed. An equivalent mathematical model of TPMLWG is established to adopt the transformation relationship...

Long-Term Clinical Outcomes of Invasive Giant Prolactinomas after a Mean Ten-Year Followup

Objective. The aim of this study is to observe clinical outcomes after more than ten years of followup in a group of patients with invasive giant prolactinomas (IGPs) treated with dopamine agonists (DAs). Methods. Twenty-five patients met the criteria of IGPs, among which 16 patients primarily received bromocriptine (BRC) and the other nine had undergone unsuccessful microsurgery...

The association of multimorbidity and disability in a community-based sample of elderly aged 80 or older in Shanghai, China

Background Both multimorbidity and activities of daily living (ADL) disability and instrument activities of daily living (IADL) disability are common among elderly individuals. ADL/IADL disability may reduce individuals’ capacities for independent living and quality of life. This study aimed to examine the association between multimorbidity and ADL/IADL disability. Methods A...

Association of TRPS1 gene with different EMT markers in ERα-positive and ERα-negative breast cancer

Background Breast cancer is a heterogeneous disease consisting of different subtypes. Trichorhinophalangeal syndrome type 1 (TRPS1) gene, a GATA-type transcription factor, has been found to be highly expressed in breast cancer. Epithelial-to-mesenchymal transition (EMT) is known to play an important role in tumour invasion and metastasis. Our objective was to elucidate the...

Overexpression of CARM1 in breast cancer is correlated with poorly characterized clinicopathologic parameters and molecular subtypes

Background Coactivator-associated arginine methyltransferase 1 (CARM1) belongs to the protein arginine methyltransferase family. CARM1 has been reported to be associated with high grade tumors in breast cancer. It still remains unknown the expression pattern of CARM1 in breast cancer and its relationships with clinicopathological characteristics and molecular subtypes. Methods...

Antiproliferative and apoptosis-inducing activity of schisandrin B against human glioma cells

Wu Qi-chuan Zhuge Wei-ming Zheng Zhi-peng Su 0 Equal contributors Department of Neurosurgery, The First Affiliated Hospital of Wenzhou Medical University , Wenzhou 325000 , China Background: Malignant

Immunohistochemical analysis of Metadherin in proliferative and cancerous breast tissue

Background Metadherin (MTDH) has been reported to be associated with cancer progression in various types of human cancers including breast cancer. Whether MTDH contributes to carcinogenesis of breast cancer is still unknown. In the present study, we investigated the expression of MTDH in normal, UDH (usual ductal hyperplasia), ADH (atypical ductal hyperplasia), DCIS (ductal...

Immunohistochemical analysis of Metadherin in proliferative and cancerous breast tissue

Metadherin (MTDH) has been reported to be associated with cancer progression in various types of human cancers including breast cancer. Whether MTDH contributes to carcinogenesis of breast cancer is still unknown. In the present study, we investigated the expression of MTDH in normal, UDH (usual ductal hyperplasia), ADH (atypical ductal hyperplasia), DCIS (ductal carcinoma in...

The Untranslated Regions of Classic Swine Fever Virus RNA Trigger Apoptosis

Classical swine fever virus (CSFV) causes a broad range of disease in pigs, from acute symptoms including high fever and hemorrhages, to chronic disease or unapparent infection, depending on the virus strain. CSFV belongs to the genus Pestivirus of the family Flaviviridae. It carries a single-stranded positive-sense RNA genome. An internal ribosomal entry site (IRES) in the 5...

53BP1 functions as a tumor suppressor in breast cancer via the inhibition of NF-κB through miR-146a

p53-binding protein-1 (53BP1) plays a critical role in cell cycle checkpoint and DNA repair activities. Recently, 53BP1 was recognized as a potential tumor suppressor gene. In this study, we investigated its tumor suppressor function in breast cancer. In clinical samples, we observed a lower level of 53BP1 expression in the cancer lesions than in the matched non-tumor tissues...