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A new coumarin derivative, IMM-H004, attenuates okadaic acid-induced spatial memory impairment in rats

; Xiu-yun SONG and Yingying WANG performed the main experiments; Xiu-yun SONG and Peng-fei YANG analyzed the data and wrote the paper; Wei ZUO, Lian-Kun SONG and Shuai ZHANG assisted in the experiments

Parent artery reconstruction for large or giant cerebral aneurysms using a Tubridge flow diverter (PARAT): study protocol for a multicenter, randomized, controlled clinical trial

Yu Zhou 0 Peng-Fei Yang 0 Yi-Bin Fang Yi Xu Bo Hong Wen-Yuan Zhao Qiang Li Rui Zhao Qing-Hai Huang Jian-Min Liu 0 Equal contributors Department of Neurosurgery, Changhai Hospital, Second Military

Downregulation of CD147 expression alters cytoskeleton architecture and inhibits gelatinase production and SAPK pathway in human hepatocellular carcinoma cells

Background CD147 plays a critical role in the invasive and metastatic activity of hepatocellular carcinoma (HCC) cells by stimulating the surrounding fibroblasts to express matrix metalloproteinases (MMPs). Tumor cells adhesion to extracellular matrix (ECM) proteins is the first step to the tumor metastasis. MMPs degrade the ECM to promote tumor metastasis. The aim of this study...

Downregulation of CD147 expression alters cytoskeleton architecture and inhibits gelatinase production and SAPK pathway in human hepatocellular carcinoma cells

CD147 plays a critical role in the invasive and metastatic activity of hepatocellular carcinoma (HCC) cells by stimulating the surrounding fibroblasts to express matrix metalloproteinases (MMPs). Tumor cells adhesion to extracellular matrix (ECM) proteins is the first step to the tumor metastasis. MMPs degrade the ECM to promote tumor metastasis. The aim of this study is to...