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36 papers found.
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Is intraindividual reaction time variability an independent cognitive predictor of mortality in old age? Findings from the Sydney Memory and Ageing Study

: Nicole A. Kochan, Sarah Pont. Formal analysis: Nicole A. Kochan, Sarah Pont. Funding acquisition: Henry Brodaty, Perminder S. Sachdev. Investigation: Nicole A. Kochan. Methodology: Nicole A. Kochan ... , David Bunce, John D. Crawford, Henry Brodaty, Perminder S. Sachdev. Project administration: Henry Brodaty, Perminder S. Sachdev. Resources: David Bunce. Supervision: David Bunce, John D. Crawford

Exercise for Individuals with Lewy Body Dementia: A Systematic Review

Background Individuals with Lewy body Dementia (LBD), which encompasses both Parkinson disease dementia (PDD) and Dementia with Lewy Bodies (DLB) experience functional decline through Parkinsonism and sedentariness exacerbated by motor, psychiatric and cognitive symptoms. Exercise may improve functional outcomes in Parkinson’s disease (PD), and Alzheimer’s disease (AD). However...

Distinct Genetic Influences on Cortical and Subcortical Brain Structures

. Wright 5 6 David Ames 7 Perminder S. Sachdev 0 1 0 Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales , Sydney, NSW 2052 , Australia 1 Neuropsychiatric Institute, Prince

A Naturalistic Study of the Acceptability and Effectiveness of Internet-Delivered Cognitive Behavioural Therapy for Psychiatric Disorders in Older Australians

Objectives The current study investigates the acceptability, effectiveness and uptake of internet-delivered cognitive behavioural therapy (iCBT) amongst older individuals (>60 years) seeking psychiatric treatment in general practice. Methods The sample consisted of 2413 (mean age 39.5; range 18–83 years) patients prescribed iCBT through This Way Up clinic by their primary care...

Psychological well-being in individuals with mild cognitive impairment

Psychological well-being in individuals with mild cognitive impairment Nicola Gates,1–3 Michael Valenzuela,3 Perminder S Sachdev,1,2,4 Maria A Fiatarone Singh5,61School of Psychiatry, 2Centre for ... , University of sydney , sydney, nsW, Australi a 1 Centre for healthy Brain Ageing (CheBA), University of n ew south Wales , sydney, nsW , Australia 2 Maria A Fiatarone singh 3 school of Psychiatry 4 Perminder s

Deep Brain Stimulation of the Antero-Medial Globus Pallidus Interna for Tourette Syndrome

Background We have previously reported the results of Deep Brain Stimulation (DBS) of the antero-medial globus pallidus interna (GPi) for severe Tourette Syndrome (TS) in 11 patients. We extend this case series to 17 patients and a longer follow-up to a maximum of 46 months. Methods 17 patients (14 male; mean age 29.1 years, range 17–51 years) with severe and medically...

High “Normal” Blood Glucose Is Associated with Decreased Brain Volume and Cognitive Performance in the 60s: The PATH through Life Study

Context Type 2 diabetes is associated with cerebral atrophy, cognitive impairment and dementia. We recently showed higher glucose levels in the normal range not to be free of adverse effects and to be associated with greater hippocampal and amygdalar atrophy in older community-dwelling individuals free of diabetes. Objective This study aimed to determine whether blood glucose...

A Combined Epigenetic and Non-Genetic Approach for Reprogramming Human Somatic Cells

Reprogramming of somatic cells to different extents has been reported using different methods. However, this is normally accompanied by the use of exogenous materials, and the overall reprogramming efficiency has been low. Chemicals and small molecules have been used to improve the reprogramming process during somatic cell nuclear transfer (SCNT) and induced pluripotent stem (iPS...

The Relationship of Serum Macrophage Inhibitory Cytokine – 1 Levels with Gray Matter Volumes in Community-Dwelling Older Individuals

Using circulating inflammatory markers and magnetic resonance imaging (MRI), recent studies have associated inflammation with brain volumetric measures. Macrophage Inhibitory Cytokine–1 (MIC-1/GDF15) is a divergent transforming growth factor – beta (TGF-β) superfamily cytokine. To uncover the underlying mechanisms of the previous finding of a negative association between MIC-1...

Microstructural White Matter Changes, Not Hippocampal Atrophy, Detect Early Amnestic Mild Cognitive Impairment

Cognitive Impairment Lin Zhuang Perminder S. Sachdev Julian N. Trollor Simone Reppermund Nicole A. Kochan Henry Brodaty Wei Wen Wang Zhan, University of Maryland, College Park, United States of America

Cognitive and memory training in adults at risk of dementia: A Systematic Review

Background Effective non-pharmacological cognitive interventions to prevent Alzheimer's dementia or slow its progression are an urgent international priority. The aim of this review was to evaluate cognitive training trials in individuals with mild cognitive impairment (MCI), and evaluate the efficacy of training in memory strategies or cognitive exercises to determine if...

Genetics of Microstructure of the Corpus Callosum in Older Adults

The current study sought to examine the relative influence of genetic and environmental factors on corpus callosum (CC) microstructure in a community sample of older adult twins. Analyses were undertaken in 284 healthy older twins (66% female; 79 MZ and 63 DZ pairs) from the Older Australian Twins Study. The average age of the sample was 69.82 (SD = 4.76) years. Brain imaging...

Grey Matter Correlates of Three Language Tests in Non-demented Older Adults

Language has been extensively investigated by functional neuroimaging studies. However, only a limited number of structural neuroimaging studies have examined the relationship between language performance and brain structure in healthy adults, and the number is even less in older adults. The present study sought to investigate correlations between grey matter volumes and three...

Age Differences in Neural Activity during Slot Machine Gambling: An fMRI Study

This study aimed to assess the potential association between age-related prefrontal brain changes and slot machine gambling, an activity that has become increasingly popular among older adults. Functional magnetic resonance imaging was used to assess healthy older and younger adults whilst playing a slot machine. Results revealed that the older group over-recruited several...

Impact of Load-Related Neural Processes on Feature Binding in Visuospatial Working Memory

Background The capacity of visual working memory (WM) is substantially limited and only a fraction of what we see is maintained as a temporary trace. The process of binding visual features has been proposed as an adaptive means of minimising information demands on WM. However the neural mechanisms underlying this process, and its modulation by task and load effects, are not well...

Investigating the Genetics of Hippocampal Volume in Older Adults without Dementia

Hippocampal atrophy is observed with ageing and age-related neurodegenerative disease. Identification of the genetic correlates of hippocampal volume (HV) and atrophy may assist in elucidating the mechanisms of ageing and age-related neurodegeneration. Using two community cohorts of older Caucasians we estimated the heritability of HV and examined associations of HV with...

The Brain Effects of Laser Acupuncture in Healthy Individuals: An fMRI Investigation

Background As laser acupuncture is being increasingly used to treat mental disorders, we sought to determine whether it has a biologically plausible effect by using functional magnetic resonance imaging (fMRI) to investigate the cerebral activation patterns from laser stimulation of relevant acupoints. Methodology/Principal Findings Ten healthy subjects were randomly stimulated...

In Vivo Hippocampal Measurement and Memory: A Comparison of Manual Tracing and Automated Segmentation in a Large Community-Based Sample

glade-Meslin 0 Perminder S. Sachdev 0 Mark W. Greenlee, University of Regensburg, Germany 0 1 Centre for Mental Health Research, Australian National University , Canberra , Australian Capital Territory

The Association between Pulse Wave Velocity and Cognitive Function: The Sydney Memory and Ageing Study

Objectives Pulse wave velocity (PWV) is a measure of arterial stiffness and its increase with ageing has been associated with damage to cerebral microvessels and cognitive impairment. This study examined the relationship between carotid-femoral PWV and specific domains of cognitive function in a non-demented elderly sample. Method Data were drawn from the Sydney Memory and Ageing...