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24 papers found.
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Manfred Eigen: the realization of his vision of Biophysical Chemistry

(Bert Sakmann), Molecular Genetics (Dieter Gallwitz), Molecular Cell Biology (Peter Gruss), Spectroscopy and Photochemical Kinetics (Jürgen Troe) as well as Molecular Developmental Biology (Herbert Jäckle

Emx2 and Pax6 Control Regionalization of the Pre-neuronogenic Cortical Primordium

It has recently been demonstrated that the transcription factor genes Emx2 and Pax6, expressed in the developing cerebral cortex along two complementary tangential gradients, are essential for the shaping of the cortical areal profile at late developmental ages, when cortical neuronogenesis is almost completed. In this study we addressed the question of whether cortical...

Sp8 controls the anteroposterior patterning at the midbrain-hindbrain border

Gundula Griesel Dieter Treichel Patrick Collombat Jens Krull Andreas Zembrzycki Willem M. R. van den Akker Peter Gruss Antonio Simeone Ahmed Mansouri The specification of neuronal cell types in the

Pax-3-DNA interaction: flexibility in the DNA binding and induction of DNA conformational changes by paired domains

The mouse Pax-3 gene encodes a protein that is a member of the Pax family of DNA binding proteins. Pax-3 contains two DNA binding domains: a paired domain (PD) and a paired type homeodomain (HD). Both domains are separated by 53 amino acids and interact synergistically with a sequence harboring an ATTA motif (binding to the HD) and a GTTCC site (binding to the PD) separated by 5...

Temporal Control of the Cre Recombinase in Transgenic Mice by a Tetracycline Responsive Promoter

Gene-targeted mice derived from embryonic stem cells are a useful tool to study gene function during development. However, if the mutation is embryonic lethal and the gene is deleted from the onset of development, later functions in adult animals cannot be studied. Recently, the bacterial Cre-loxP site-specific recombination system has successfully been used in transgenic animals...

Pax genes in development

Ahmed Mansouri 0 Anastassia Stoykova 0 Peter Gruss 0 0 Max-Plank-Institut fur biophysikalische Chemie, Abteilung Molekulare Zellbiologie , Am Fassberg, D-37077 Gottingen , Germany The Pax gene

Evidence for the Stochastic Integration of Gene Trap Vectors into the Mouse Germline

A large scale insertional mutagenesis experiment was performed in embryonic stem (ES) cells by introducing two types of gene trap vectors into the genome. These cell lines carrying mutations were introduced into the mouse germline. In order to assess the feasibility of a large scale cloning of the targeted genes from these lines, we have isolated and characterized 55 trapped...