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Is early detection of late-onset Pompe disease a pneumologist’s affair? A lesson from an Italian screening study

Late-onset Pompe disease (LOPD) is a recessive disease caused by α-glucosidase (GAA) deficiency, leading to progressive muscle weakness and/or respiratory failure in children and adults. Respiratory derangement can be the first indication of LOPD, but the diagnosis may be difficult for pneumologists. We hypothesize that assessing the GAA activity in suspected patients by a dried...

Blood MCP-1 levels are increased in chronic obstructive pulmonary disease patients with prevalent emphysema

Ceriana 3 0 Department of Molecular and Developmental Medicine, University of siena , siena , Italy 1 l aboratory of experimental and Clinical Toxicology, Toxicology Unit, ICs Maugeri s pa s ocietà Benefit

Short-term effects of a nicotine-free e-cigarette compared to a traditional cigarette in smokers and non-smokers

Background A few studies have assessed the short-term effects of low-dose nicotine e-cigarettes, while data about nicotine-free e-cigarettes (NF e-cigarettes) are scanty. Concerns have been expressed about the use of NF e-cigarettes, because of the high concentrations of propylene glycol and other compounds in the e-cigarette vapor. Methods This laboratory-based study was aimed...

Patient-ventilator asynchronies: may the respiratory mechanics play a role?

Introduction The mechanisms leading to patient/ventilator asynchrony has never been systematically assessed. We studied the possible association between asynchrony and respiratory mechanics in patients ready to be enrolled for a home non-invasive ventilatory program. Secondarily, we looked for possible differences in the amount of asynchronies between obstructive and restrictive...

Determinants of weaning success in patients with prolonged mechanical ventilation

Introduction Physiological determinants of weaning success and failure are usually studied in ventilator-supported patients, comparing those who failed a trial of spontaneous breathing with those who tolerated such a trial and were successfully extubated. A major limitation of these studies was that the two groups may be not comparable concerning the severity of the underlying...