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c-FLIP is a target of the E3 ligase deltex1 in gastric cancer

in:Nature Research journals • PubMed • Google Scholar Search for Ping-Ning Hsu in:Nature Research journals • PubMed • Google Scholar Search for Ming-Zong Lai in:Nature Research journals • PubMed • Google

Estimating the Economic Burden of Rheumatoid Arthritis in Taiwan Using the National Health Insurance Database

manuscript. Ya-Wen Yang is an employee of Pfizer Taiwan. Chi-Hui Fang was an employee of Pfizer during the development of the study and manuscript. Chao-Hsiun Tang and Ping-Ning Hsu have no conflicts of

IL-6, through p-STAT3 rather than p-STAT1, activates hepatocarcinogenesis and affects survival of hepatocellular carcinoma patients: a cohort study

Background Biologic activities of functional mediators activate downstream transducers regulating inflammation and carcinogenesis. Correlation among mediators (IL-6, IL-27, TNF-α, and VEGF) with STAT proteins at diverse clinical-pathologic stages of hepatocellular carcinoma (HCC) remains limited. Methods Serum mediators assayed from 147 untreated HCC cases (HCC-total group...

Tumor Necrosis Factor-Alpha Induced by Hepatitis B Virus Core Mediating the Immune Response for Hepatitis B Viral Clearance in Mice Model

Persistent hepatitis B viral (HBV) infection results in chronic hepatitis, liver cirrhosis, and hepatocellular carcinoma (HCC). An efficient control of virus infections requires the coordinated actions of both innate and adaptive immune responses. In order to define the role of innate immunity effectors against HBV, viral clearance was studied in a panel of immunodeficient mouse...

TRAF-6 Dependent Signaling Pathway Is Essential for TNF-Related Apoptosis-Inducing Ligand (TRAIL) Induces Osteoclast Differentiation

Human osteoclast formation from mononuclear phagocyte precursors involves interactions between tumor necrosis factor (TNF) ligand superfamily members and their receptors. Recent evidence indicates that in addition to triggering apoptosis, the TNF-related apoptosis-inducing ligand (TRAIL) induces osteoclast differentiation. To understand TRAIL-mediated signal transduction...

Spontaneous inflammatory pain model from a mouse line with N-ethyl-N-nitrosourea mutagenesis

BackgroundN-ethyl-N-nitrosourea mutagenesis was used to induce a point mutation in C57BL/6 J mice. Pain-related phenotype screening was performed in 915 G3 mice. We report the detection of a heritable recessive mutant in meiotic recombinant N1F1 mice that caused an abnormal pain sensitivity phenotype with spontaneous skin inflammation in the paws and ears.MethodsWe investigated...

PD-1 Blockage Reverses Immune Dysfunction and Hepatitis B Viral Persistence in a Mouse Animal Model

Persistent hepatitis B viral (HBV) infection results in chronic hepatitis, liver cirrhosis, and hepatocellular carcinoma (HCC). Recent studies in animal models of viral infection indicate that the interaction between the inhibitory receptor, programmed death (PD)-1, on lymphocytes and its ligand (PD-L1) play a critical role in T-cell exhaustion by inducing T-cell inactivation...

Inhibition of Helicobacter pylori CagA-Induced Pathogenesis by Methylantcinate B from Antrodia camphorata

 David T. W. Tzeng,5 Ping-Ning Hsu,6 Chih-Ho Lai,1,7 and Yew-Min Tzeng2 1Graduate Institute of Clinical Medical Science, China Medical University, Taichung 40402, Taiwan 2Institute of Biochemical Sciences ... Dr. Ping-Ning Hsu of the Graduate Institute of Immunology, College of Medicine, National Taiwan University [19]. All Hp strains were cultured and maintained on Brucella agar plates (Becton Dickinson

Preferential Induction of Transforming Growth Factor—β Production in Gastric Epithelial Cells and Monocytes by Helicobacter pylori Soluble Proteins

Background. The cytokines induced by Helicobacter pylori, as well as the intricate balance of proinflammatory and anti-inflammatory cytokines, are relevant to the outcomes of H. pylori infection. Transforming growth factor (TGF)—β and interleukin (IL)—10 are 2 vital anti-inflammatory cytokines that regulate mucosal immunity in various inflammatory and infectious diseases. Methods...