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33 papers found.
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Primary Biliary Cirrhosis in A Patient with Turner Syndrome

P Milkiewicz, J Heathcote. Primary biliary cirrhosis in a patient with Turner syndrome. Can J Gastroenterol Primary biliary cirrhosis in a patient with Turner syndrome Piotr Milkiewicz Jenny ... Correspondence: Dr Piotr Milkiewicz, Toronto Western Hospital, University Health Network, 399 Bathurst Street, 6B Fell Pavilon, Room 172, Toronto, Ontario M5T 2S8. Telephone 416-603-5800, fax 416-603-6281, e-mail

Primary Biliary Cirrhosis in A Patient with Turner Syndrome

P Milkiewicz, J Heathcote. Primary biliary cirrhosis in a patient with Turner syndrome. Can J Gastroenterol Primary biliary cirrhosis in a patient with Turner syndrome Piotr Milkiewicz Jenny ... Correspondence: Dr Piotr Milkiewicz, Toronto Western Hospital, University Health Network, 399 Bathurst Street, 6B Fell Pavilon, Room 172, Toronto, Ontario M5T 2S8. Telephone 416-603-5800, fax 416-603-6281, e-mail

Diffuse Skin Reaction in Patient with Hepatitis B, Treated with Two Different Formulations of Pegylated Interferon

reaction in a patient with hepatitis B, treated with two different formulations of pegylated interferon Piotr Milkiewicz Colina Yim RN Isabelle Pache Jenny Heathcote Diffuse skin reactions, commonly ... , University Health Network, Toronto, Ontario; 2Department of Gastroenterology, Pomeranian Medical School, Unii Lubelskiej 1, Poland. Correspondence: Dr Piotr Milkiewicz, Toronto Western Hospital, University

Diffuse Skin Reaction in Patient with Hepatitis B, Treated with Two Different Formulations of Pegylated Interferon

reaction in a patient with hepatitis B, treated with two different formulations of pegylated interferon Piotr Milkiewicz Colina Yim RN Isabelle Pache Jenny Heathcote Diffuse skin reactions, commonly ... , University Health Network, Toronto, Ontario; 2Department of Gastroenterology, Pomeranian Medical School, Unii Lubelskiej 1, Poland. Correspondence: Dr Piotr Milkiewicz, Toronto Western Hospital, University

PNPLA3 p.I148M and TM6SF2 p.E167K variants do not predispose to liver injury in cholestatic liver diseases: A prospective analysis of 178 patients with PSC

Conceptualization: Marcin Krawczyk. 9 / 11 Formal analysis: Beata Kruk, Roman Liebe, Piotr Milkiewicz, Marcin Krawczyk. Investigation: Beata Kruk, Marcin Krawczyk. Methodology: Beata Kruk, Maøgorzata Milkiewicz ... , Piotr Milkiewicz. Project administration: Beata Kruk, Piotr Milkiewicz, Marcin Krawczyk. Resources: Maøgorzata Milkiewicz, Piotr Milkiewicz. Supervision: Marcin Krawczyk. Validation: Ewa Wunsch

N-3 Polyunsaturated Fatty Acids Stimulate Bile Acid Detoxification in Human Cell Models

Cholestasis is characterized by the accumulation of toxic bile acids (BAs) in liver cells. The present study aimed to evaluate the effects of n-3 polyunsaturated fatty acids (n-3 PUFAs), such as docosahexaenoic (DHA) and eicosapentaenoic (EPA) acids, on BA homeostasis and toxicity in human cell models. The effects of EPA and/or DHA on the expression of genes involved in the...

Urinary Elimination of Bile Acid Glucuronides under Severe Cholestatic Situations: Contribution of Hepatic and Renal Glucuronidation Reactions

Trottier,1 Mélanie Verreault,1 Patrick Caron,1 Guy G. Poirier,3 Piotr Milkiewicz,4 and Olivier Barbier1 1Laboratory of Molecular Pharmacology, CHU-Québec Research Centre and the Faculty of Pharmacy, Laval ... Recherche en Santé du Québec” (FRSQ #23444). Olivier Barbier is holder of a salary grant from CIHR (New Investigator #MSH95330). Piotr Milkiewicz was supported by Grants #DEC-2011/01/B/NZ5/04216 and 2011/02/A

Urinary Elimination of Bile Acid Glucuronides under Severe Cholestatic Situations: Contribution of Hepatic and Renal Glucuronidation Reactions

Trottier,1 Mélanie Verreault,1 Patrick Caron,1 Guy G. Poirier,3 Piotr Milkiewicz,4 and Olivier Barbier1 1Laboratory of Molecular Pharmacology, CHU-Québec Research Centre and the Faculty of Pharmacy, Laval ... Recherche en Santé du Québec” (FRSQ #23444). Olivier Barbier is holder of a salary grant from CIHR (New Investigator #MSH95330). Piotr Milkiewicz was supported by Grants #DEC-2011/01/B/NZ5/04216 and 2011/02/A

Protection against oxidative stress mediated by the Nrf2/Keap1 axis is impaired in Primary Biliary Cholangitis

Declaration of Helsinki (6th revision, 2008). Acknowledgements Piotr Milkiewicz was supported by the grant no. 2011/02/A/NZ5/00321 from National Science Centre in Poland. Ma?gorzata Milkiewicz was supported

ApaI polymorphism of vitamin D receptor affects health-related quality of life in patients with primary sclerosing cholangitis

Background Polymorphisms of vitamin D receptor (VDR) contribute to the pathogenesis of multiple autoimmune conditions. Methods We investigated the incidence of VDR polymorphisms (rs1544410-BsmI; rs7975232-ApaI; rs731236-TaqI) in a group of patients with primary sclerosing cholangitis (PSC, n = 275) and in healthy controls (n = 376). Additionally, correlations of the VDR...

Good outcome following liver transplantation using pericardial-peritoneum window for hepato-atrial anastomosis to overcome advanced hepatic alveolar echinococcosis and secondary Budd-Chiari Syndrome - a case report

Background This report presents a case of a 57- year old female with advanced Hepatic Alveolar Echinococcosis causing a secondary Budd-Chiari Syndrome due to infiltration of the suprahepatic inferior vena cava treated successfully by liver transplantation. Case presentation A temporary veno-venous bypass was introduced, but a typical end to end cavo-caval anastomosis wasn’t...

Liver Expression of Sulphotransferase 2A1 Enzyme Is Impaired in Patients with Primary Sclerosing Cholangitis: Lack of the Response to Enhanced Expression of PXR

. Acknowledgments Ewa Wunsch was supported by the Foundation for Polish Science. Piotr Milkiewicz was supported by Grant nos. 2011/01/B/NZ5/04216 and 2011/02/A/NZ5/00321 from National Science Centre in Poland

Liver Expression of Sulphotransferase 2A1 Enzyme Is Impaired in Patients with Primary Sclerosing Cholangitis: Lack of the Response to Enhanced Expression of PXR

. Acknowledgments Ewa Wunsch was supported by the Foundation for Polish Science. Piotr Milkiewicz was supported by Grant nos. 2011/01/B/NZ5/04216 and 2011/02/A/NZ5/00321 from National Science Centre in Poland

Variant adiponutrin confers genetic protection against cholestatic itch

Wunsch 4 Piotr Milkiewicz 3 4 Frank Lammert 2 0 Sahlgrenska Academy, Institute of Medicine, Department of Molecular and Clinical Medicine, University of Gothenburg , Gothenburg , Sweden 1 Medical Biology

Mini-Mental State Examination in patients with hepatic encephalopathy and liver cirrhosis: a prospective, quantified electroencephalography study

Background Mini-Mental State Examination (MMSE) is one of the most commonly used methods in the assessment of cognitive mental status. MMSE has been used in hepatology but its usefulness in the evaluation of hepatic encephalopathy (HE) has never been properly assessed. The aim of the study was to investigate the value of MMSE in detection of HE in patients with cirrhosis. Methods...

Role of Glucuronidation for Hepatic Detoxification and Urinary Elimination of Toxic Bile Acids during Biliary Obstruction

Biliary obstruction, a severe cholestatic condition, results in a huge accumulation of toxic bile acids (BA) in the liver. Glucuronidation, a conjugation reaction, is thought to protect the liver by both reducing hepatic BA toxicity and increasing their urinary elimination. The present study evaluates the contribution of each process in the overall BA detoxification by...

Ursodeoxycholic Acid Influences the Expression of but Not FoxO1 in Patients with Non-Cirrhotic Primary Biliary Cirrhosis

Background. Enhanced expression of cell cycle inhibitor suppresses cell proliferation. Ursodeoxycholic acid (UDCA) delays progression of primary biliary cirrhosis (PBC) but its effect on expression is uncertain. Aims. To analyze the expression of and its transcription modulator FoxO1 in patients with PBC, and to assess the impact of UDCA on this pathway. Materials and Methods...

Factors Affecting Health-Related Quality of Life and Physical Activity after Liver Transplantation for Autoimmune and Nonautoimmune Liver Diseases: A Prospective, Single Centre Study

Background/Aim. With the improvement of the outcomes after liver transplantation (LTx), health-related quality of life (HRQoL) and physical activity are becoming significant outcome parameters. We prospectively assessed these parameters in patients with autoimmune and nonautoimmune liver disorders undergoing LTx. Materials and Methods. Patients () were subdivided into 3 groups...

The Efficacy and Safety of Endoscopic Ultrasound-Guided Celiac Plexus Neurolysis for Treatment of Pain in Patients with Pancreatic Cancer

Introduction. Celiac plexus neurolysis is used in pain management of patients with advanced and unresectable pancreatic cancer. We retrospectively analyzed efficacy and safety of endoscopic ultrasound- (EUS-) guided celiac plexus neurolysis in patients treated in our unit. Methods. Twenty nine subjects with unresectable pancreatic cancer and severe pain despite pharmacological...

The Efficacy and Safety of Endoscopic Ultrasound-Guided Celiac Plexus Neurolysis for Treatment of Pain in Patients with Pancreatic Cancer

Introduction. Celiac plexus neurolysis is used in pain management of patients with advanced and unresectable pancreatic cancer. We retrospectively analyzed efficacy and safety of endoscopic ultrasound- (EUS-) guided celiac plexus neurolysis in patients treated in our unit. Methods. Twenty nine subjects with unresectable pancreatic cancer and severe pain despite pharmacological...