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Clinical benefit from afatinib in an advanced squamous cell lung carcinoma patient harboring HER2 S310Y mutation: a case report

Clinical benefit from afatinib in an advanced squamous cell lung carcinoma patient harboring HER2 S310Y mutation: a case report Yan Gao,1 Aihong Zheng,2 Xiuming Zhu,2 Jia Song,3 Qian Xue2 1Department of Western Medicine, Wenxin Community Health Service Center, Hangzhou 310016, China; 2The Department of Medical Oncology, Zhejiang Provincial People’s Hospital, Hangzhou 310014...

3D Progressive Damage Based Macro-Mechanical FE Simulation of Machining Unidirectional FRP Composite

manufacturing, etc. E?mail: . Hong? Qian Xue, born in 1967, is currently a professor at School of Mechanical Engineering, Northwestern Polytechnical University, China. He received his PhD degree from

Transcriptomic profile of leg muscle during early growth in chicken

The early growth pattern, especially the age of peak growth, of broilers affects the time to market and slaughter weight, which in turn affect the profitability of the poultry industry. However, the underlying mechanisms regulating chicken growth and development have rarely been studied. This study aimed to identify candidate genes involved in chicken growth and investigated the...

Antidepressant Effects of (+)-MK-801 and (-)-MK-801 in the Social Defeat Stress Model

Current data on antidepressant action of the N-methyl-D-aspartate receptor antagonist, (+)-MK-801, is inconsistent. This study was conducted to examine the effects of (+)-MK-801 and its less potent stereoisomer, (-)-MK-801, in the social defeat stress model of depression.

Analysis of long noncoding RNA and mRNA using RNA sequencing during the differentiation of intramuscular preadipocytes in chicken

Long noncoding RNAs (lncRNAs) regulate metabolic tissue development and function, including adipogenesis. However, little is known about the function and profile of lncRNAs in intramuscular preadipocyte differentiation in chicken. Here, we identified lncRNAs in chicken intramuscular preadipocytes at different differentiation stages using RNA sequencing. A total of 1,311,382,604...

The cut-off value of tumor size and appropriate timing of follow-up for management of minimal EUS-suspected gastric gastrointestinal stromal tumors

Backgroud The detectable rate of minimal gastric GISTs has continuously increased. While the surveillance and management of GIST <2 cm have been deemed controversial or lack evidence-based approaches.  The aim of the current study is to propose a cut-off value of tumor size for treatment policy and the appropriate timing for endoscopic ultrasonography (EUS) follow-up in the...

Comparison of R-ketamine and rapastinel antidepressant effects in the social defeat stress model of depression

Rationale The N-methyl-d-aspartate (NMDA) receptor antagonists, including R-ketamine and rapastinel (formerly GLYX-13), show rapid antidepressant effects in animal models of depression. Objective We compared the rapid and sustained antidepressant effects of R-ketamine and rapastinel in the social defeat stress model. Results In the tail suspension and forced swimming tests, R...

miR-9 and miR-124 synergistically affect regulation of dendritic branching via the AKT/GSK3β pathway by targeting Rap2a

A single microRNA (miRNA) can regulate expression of multiple proteins, and expression of an individual protein may be controlled by numerous miRNAs. This regulatory pattern strongly suggests that synergistic effects of miRNAs play critical roles in regulating biological processes. miR-9 and miR-124, two of the most abundant miRNAs in the mammalian nervous system, have important...

Engineering optical mode ferromagnetic resonance in FeCoB films with ultrathin Ru insertion

Ferromagnetic resonance (FMR) in soft magnetic films (SMFs) to a large extent determines the maximum working frequency of magnetic devices. The FMR frequency (fr) in an optical mode is usually much higher than that in the corresponding acoustic mode for exchange coupled ferromagnet/nonmagnet/ferromagnet (FM/NM/FM) trilayers. In this study, we prepared a 50 nm FeCoB film with...

Discovery and structural optimization of 4-(4-(benzyloxy)phenyl)-3,4-dihydropyrimidin-2(1H)-ones as RORc inverse agonists

, and Yan-li XING, performed the experiments. All authors participated in data acquisition, analysis, and interpretation. Xi-shan WU, Rui WANG, Yan-li XING, Xiao-qian XUE, Yan ZHANG, and Yong XU wrote the

A soybean MADS-box protein modulates floral organ numbers, petal identity and sterility

Background The MADS-box transcription factors play fundamental roles in reproductive developmental control. Although the roles of many plant MADS-box proteins have been extensively studied, there are almost no functional studies of them in soybean, an important protein and oil crop in the world. In addition, the MADS-box protein orthologs may have species-specific functions...

Spatial and temporal variations of C3/C4 relative abundance in global terrestrial ecosystem since the Last Glacial and its possible driving mechanisms

The primary factor controlling C3/C4 relative abundance in terrestrial ecosystem since the Last Glacial has been widely debated. Now more and more researchers recognize that climate, rather than atmospheric CO2 concentration, is the dominant factor. However, for a specific area, conflicting viewpoints regarding the more influential one between temperature and precipitation still...

MiR-568 inhibits the activation and function of CD4+ T cells and Treg cells by targeting NFAT5

CD4+ T cells play critical roles in orchestrating adaptive immune responses. Their activation and proliferation are critical steps that occur before they execute their biological functions. Despite the important role of this process, the underlying molecular events are not fully understood. MicroRNAs (miRNAs) have been shown to play important roles in lymphocyte development and...

Evidence for transcriptional interference in a dual-luciferase reporter system

Shangtang Road, Hangzhou, Zhejiang 310014, ChinaGuo-Qing Wu, Xiao Wang, Hong-Ying Zhou, Qian Xue, Ai-Hong Zheng, Xiu-Ming Zhu, Fu-Wei Wang, Tao Rui, Li-Qin Lu & Dong-Sheng HuangZhejiang Academy of Traditional ... Zhou in:Nature Research journals • PubMed • Google ScholarSearch for Ke-Qun Chai in:Nature Research journals • PubMed • Google ScholarSearch for Qian Xue in:Nature Research journals • PubMed • Google

TLR3 and TLR7 Modulate IgE Production in Antigen Induced Pulmonary Inflammation via Influencing IL-4 Expression in Immune Organs

Background Toll-like receptors (TLRs) as pattern recognition receptors, participate in both innate and adaptive immune responses, and seem to play an important role in the pathogenesis of asthma. This study aimed to identify key TLRs involved in antigen induced pulmonary inflammation (AIPI), a rat model for asthma, and to explore the role of TLRs in the disease development...