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Preoperative Sleep Disturbance Exaggerates Surgery-Induced Neuroinflammation and Neuronal Damage in Aged Mice

Postoperative cognitive dysfunction (POCD) is defined as new cognitive impairment (memory impairment and impaired performance) after surgery, especially in aged patients. Sleep disturbance is a common phenomenon before surgery that has been increasingly thought to affect patient recovery. However, little is known about the functional impact of preoperative sleep disturbance on...

Candida glabrata-Induced Refractory Infectious Arthritis: A Case Report and Literature Review

Yi-qin Zhou have contributed equally to this work. Handling Editor: Weida Liu. Introduction Candida glabrata mainly causes systemic or mucosal infections in immunosuppressed patients due to the

IL-17A contributes to perioperative neurocognitive disorders through blood-brain barrier disruption in aged mice

Perioperative neurocognitive disorders (PND) occur frequently after surgery, especially in aged patients. Surgery-induced neuroinflammation and blood-brain barrier (BBB) dysfunction play a crucial role in the pathogenesis of PND. Interleukin-17A (IL-17A) increases after surgical stress and will be involved in BBB dysfunction. However, the effect of IL-17A on BBB function during...

Protective effects of γ-aminobutyric acid against H 2 O 2 -induced oxidative stress in RIN-m5F pancreatic cells

γ-Aminobutyric acid (GABA) is a major inhibitory neurotransmitter in the central nervous system and reported to maintain the redox homeostasis and insulin secretion function of pancreatic β cells. This study tested the hypothesis that GABA maintains cellular redox status, and modulates glycogen synthase kinase (GSK)-3β and antioxidant-related nuclear factor erythroid 2-related...

Heat transfer across a nanoscale pressurized air gap and its application in magnetic recording

In this study, we investigated how a thermally actuated air bearing slider heats up a fast-spinning storage disk through a highly pressurized nanoscale air gap in a magnetic recording system. A Eulerian-description-based computational approach is developed considering heat conduction through a pressurized air film and near-field radiation across the gap. A set of field equations...

PQQ ameliorates D-galactose induced cognitive impairments by reducing glutamate neurotoxicity via the GSK-3β/Akt signaling pathway in mouse

Oxidative stress is known to be associated with various age-related diseases. D-galactose (D-gal) has been considered a senescent model which induces oxidative stress response resulting in memory dysfunction. Pyrroloquinoline quinone (PQQ) is a redox cofactor which is found in various foods. In our previous study, we found that PQQ may be converted into a derivative by binding...

Lack of human-like extracellular sortilin neuropathology in transgenic Alzheimer’s disease model mice and macaques

BackgroundAlzheimer’s disease (AD) is a devastating neurodegenerative disorder bearing multiple pathological hallmarks suggestive of complex cellular/molecular interplay during pathogenesis. Transgenic mice and nonhuman primates are used as disease models for mechanistic and translational research into AD; the extent to which these animal models recapitulate AD-type...

Leptin Promotes Allergic Airway Inflammation through Targeting the Unfolded Protein Response Pathway

, Xiang Wu, Qin Zhou, Cameron J. Chock & Xuexian O. YangDepartment of Biochemistry and Molecular Biology, University of New Mexico Health Sciences Center, Albuquerque, NM, 87131, USADandan Wu, Xing Zhang ... Search for Xiang Wu in:Nature Research journals • PubMed • Google Scholar Search for Xing Zhang in:Nature Research journals • PubMed • Google Scholar Search for Qin Zhou in:Nature Research journals

Nimotuzumab combined with concurrent chemoradiotherapy benefits patients with advanced nasopharyngeal carcinoma

Nimotuzumab combined with concurrent chemoradiotherapy benefits patients with advanced nasopharyngeal carcinoma Zhanzhan Li,1 Yanyan Li,2 Shipeng Yan,3 Jun Fu,1 Qin Zhou,1 Xinqiong Huang,1 Liangfang

Analysis of Seismic Soil-Structure Interaction for a Nuclear Power Plant (HTR-10)

The response of nuclear power plants (NPPs) to seismic events is affected by soil-structure interactions (SSI). In the present paper, a finite element (FE) model with transmitting boundaries is used to analyse the SSI effect on the response of NPP buildings subjected to vertically incident seismic excitation. Analysis parameters that affect the accuracy of the calculations...

Analysis of Seismic Soil-Structure Interaction for a Nuclear Power Plant (HTR-10)

The response of nuclear power plants (NPPs) to seismic events is affected by soil-structure interactions (SSI). In the present paper, a finite element (FE) model with transmitting boundaries is used to analyse the SSI effect on the response of NPP buildings subjected to vertically incident seismic excitation. Analysis parameters that affect the accuracy of the calculations...

Mild endoplasmic reticulum stress ameliorates lipopolysaccharide-induced neuroinflammation and cognitive impairment via regulation of microglial polarization

Neuroinflammation, which ultimately leads to neuronal loss, is considered to play a crucial role in numerous neurodegenerative diseases. The neuroinflammatory process is characterized by the activation of glial cells such as microglia. Endoplasmic reticulum (ER) stress is commonly associated with impairments in neuronal function and cognition, but its relationship and role in...

Mild endoplasmic reticulum stress ameliorates lipopolysaccharide-induced neuroinflammation and cognitive impairment via regulation of microglial polarization

Neuroinflammation, which ultimately leads to neuronal loss, is considered to play a crucial role in numerous neurodegenerative diseases. The neuroinflammatory process is characterized by the activation of glial cells such as microglia. Endoplasmic reticulum (ER) stress is commonly associated with impairments in neuronal function and cognition, but its relationship and role in...

Time to publication of oncology trials and why some trials are never published

, George J. Bosl, David R. Spriggs. Data curation: Paul B. Chapman, Nathan J. Liu, Sara Hanley. Formal analysis: Paul B. Chapman, Nathan J. Liu, Qin Zhou, Alexia Iasonos, David R. Spriggs. Methodology ... : Paul B. Chapman, Nathan J. Liu, Qin Zhou, Alexia Iasonos, Sara Hanley. Resources: George J. Bosl. 11 / 13 Supervision: Paul B. Chapman, Sara Hanley, David R. Spriggs. Writing ± original draft: Paul B

Sulforaphane Attenuates Contrast-Induced Nephropathy in Rats via Nrf2/HO-1 Pathway

Background. Oxidative stress plays an important role in the pathogenesis of contrast-induced nephropathy (CIN). The aim of this study was to investigate the antioxidant effects of sulforaphane (SFN) in a rat model of CIN and a cell model of oxidative stress in HK2 cells. Methods. Rats were randomized into four groups ( per group): control group, Ioversol group (Ioversol-induced...

Sulforaphane Attenuates Contrast-Induced Nephropathy in Rats via Nrf2/HO-1 Pathway

Background. Oxidative stress plays an important role in the pathogenesis of contrast-induced nephropathy (CIN). The aim of this study was to investigate the antioxidant effects of sulforaphane (SFN) in a rat model of CIN and a cell model of oxidative stress in HK2 cells. Methods. Rats were randomized into four groups ( per group): control group, Ioversol group (Ioversol-induced...

rLj-RGD3, a Novel Recombinant Toxin Protein from Lampetra japonica, Protects against Cerebral Reperfusion Injury Following Middle Cerebral Artery Occlusion Involving the Integrin-PI3K/Akt Pathway in Rats

Background The RGD-toxin protein Lj-RGD3 is a naturally occurring 118 amino acid peptide that can be obtained from the salivary gland of the Lampetra japonica fish. This unique peptide contains 3 RGD (Arg-Gly-Asp) motifs in its primary structure. Lj-RGD3 is available in recombinant form (rLj-RGD3) and can be produced in large quantities using DNA recombination techniques. The...

MicroRNA Array Normalization: An Evaluation Using a Randomized Dataset as the Benchmark

MicroRNA arrays possess a number of unique data features that challenge the assumption key to many normalization methods. We assessed the performance of existing normalization methods using two microRNA array datasets derived from the same set of tumor samples: one dataset was generated using a blocked randomization design when assigning arrays to samples and hence was free of...

Edaravone attenuates hippocampal damage in an infant mouse model of pneumococcal meningitis by reducing HMGB1 and iNOS expression via the Nrf2/HO-1 pathway

agent for therapeutic interventions in BM. Author contribution Zheng LI designed the study; Qian-qian MA and Yan YAN performed the experiments; Wei-qin ZHOU contributed new reagents or analytical tools