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11 papers found.
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Excess genistein suppresses the synthesis of extracellular matrix in female rat mandibular condylar cartilage

individuals, the proper genistein dose should be studied further if genistein is to be widely used to treat OA or osteoporosis. Author contribution Mei-qing WANG and Shi-bin YU designed the study and wrote ... -hui Xing, Guang-ying Dong, Xi-li Weng & Mei-qing Wang AuthorsSearch for Shi-bin Yu in:Nature Research journals • PubMed • Google ScholarSearch for Xiang-hui Xing in:Nature Research journals • PubMed

The mineralocorticoid receptor-p38MAPK-NFκB or ERK-Sp1 signal pathways mediate aldosterone-stimulated inflammatory and profibrotic responses in rat vascular smooth muscle cells

diseases. Author contribution Zhuo-wei HU directed the research; Chuan-jiang ZHU conducted the research and wrote and revised the manuscript; Qing-qing WANG, Jun-lan ZHOU, and Han-zhi LIU assisted with ... -jiang Zhu, Qing-qing Wang, Jun-lan Zhou, Han-zhi Liu, Fang Hua, Hong-zheng Yang & Zhuo-wei Hu AuthorsSearch for Chuan-jiang Zhu in:Nature Research journals • PubMed • Google ScholarSearch for Qing-qing

Protective effects of tiopronin against high fat diet-induced non-alcoholic steatohepatitis in rats

Jun LI, Yu-hong ZOU, and Jian-qing WANG designed and apoptosis in patients with nonalcoholic steatohepatitis. Liver Int research; Jian-qing WANG and Cheng HUANG performed 2009; 29: 1184?8. research ... , Xiong-wen L?, and Li-ping LIU study. J Gastrointestin Liver Dis 2007; 16: 39?46. analyzed data; Jian-qing WANG wrote the paper; and Yu- 19 Laurin J, Lindor KD, Crippin JS, Gossard A, Gores GJ, Ludwig J

Pioglitazone ameliorates memory deficits in streptozotocin-induced diabetic mice by reducing brain β-amyloid through PPARγ activation

ZHANG, Yan LONG, diabetes. Proc Natl Acad Sci U S A 2010 ; 107: 7036?41. Jiang-qing WANG, Yong-qi LI, and Mei HU participated in 18 Sood V, Colleran K, Burge MR. Thiazolidinediones: a comparative ELISA

Strontium ranelate reduces cartilage degeneration and subchondral bone remodeling in rat osteoarthritis model

performed the micro-CT imaging experiments. Bo YU, Xiao-qing WANG, Yang LI, and Guang-wang LIU performed the Raman and nanoindentation analysis. Shao-bo NIE, Shen LIU, and Zhen-an ZHU conceived the study ... Mao, Ming Liu, Xin Zhao, Xiao-qing Wang, Yang Li, Guang-wang Liu & Zhen-an ZhuDepartment of Orthopedics, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Ji-nan 250014

Immunostimulatory and anti-neoplasm effects of a novel palindrome CpG oligodeoxynucleotide in mice

Aim:DNAs containing unmethylated CpG motifs can stimulate innate and adaptive immunity. The aim of this study was to investigate the immunostimulatory and anti-neoplasm effects of a novel CpG oligodeoxynucleotide, ODN10, in tumor-bearing mice.Methods:B16 melanoma-bearing C57BL/6 mice were administered ip or sc with ODN10 or conventional CpG ODN1826 on the indicated days post...

Efficacy of zoledronic acid in treatment of teoarthritis is dependent on the disease progression stage in rat medial meniscal tear model

immunohistochemical experiments. Yuan-qing MAO and Xin ZHAO performed micro-CT imaging experiments. Xiao-qing WANG, Hui-feng DING, Lei CAO, Guangwang LIU, Shao-bo NIE, Shen LIU, and Zhen-an ZHU conceived the study ... , designed the experiments, participated in data analysis and helped to draft the manuscript. Xiao-qing Wang and Guang-wang LIU performed H&E staing and synovial reaction evaluation in the supplementary study

Interleukin-17A is involved in development of spontaneous pulmonary emphysema caused by Toll-like receptor 4 mutation

, Hui-min YAN, Yong-gang MA, and Xiao-xing WANG performed part of the research experiments together with Qing-qing WANG; and Zhuo-wei HU conceived and designed the experiments, edited and modified the ... the CheungKong Scholars Programme from the Ministry of Education and the Senior Oversea Chinese Scholar Fund from the Ministry of Personnel of People?s Republic of China. Author contribution Qing-qing

Effect of telmisartan on expression of protein kinase C-α in kidneys of diabetic mice

Aim:To investigate the effects of angiotensin receptor blocker (ARB) telmisartan on the expression and distribution of protein kinase C (PKC)-α in the kidneys of diabetic mice.Methods:Diabetic mice were induced with streptozotocin and a group of them were randomly selected for treatment with telmisartan. After 6 weeks, the expression and localization of PKC-α in the renal cortex...

The anti-endotoxic effect of o-aminobenzoic acid from Radix Isatidis

Aim:To study the anti-endotoxic effect of o-aminobenzoic acid (OABA) isolated from Banlangen(BLG).Methods:OABA was extracted and isolated from BLG and diluted into 0.5% solution. The concentration of endotoxin (ET) pretreated with OABA was quantitatively detected using Limulus test. The inhibition of ET-induced fever by OABA was measured in rabbits. The rates of...

Structure-efficacy relationships of immunostimulatory activity of CpG-containing oligodeoxynucleotides on mouse spleen cells

Aim:To study the relationship between primary structures of oligodeoxynucleo-tides (ODN) containing unmethylated deoxycytidyl-deoxyguanosine (CpG) dinucleotide motifs and their immunostimulatory activities in mouse spleen cells.Methods:A series of CpG ODN with different primary structures were synthesized. Their capabilities to stimulate mouse spleen cell proliferation were...