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Salvianolic acid B inhibits mitochondrial dysfunction by up-regulating mortalin

, acquisition of data, analysis, interpretation of data and drafting the manuscript. Qiukai E was involved in acquisition of data. Ji Zuo revised the manuscript for important intellectual content. Ling Yang and

Targeting GRP75 Improves HSP90 Inhibitor Efficacy by Enhancing p53-Mediated Apoptosis in Hepatocellular Carcinoma

Heat shock protein 90 (HSP90) inhibitors are potential drugs for cancer therapy. The inhibition of HSP90 on cancer cell growth largely through degrading client proteins, like Akt and p53, therefore, triggering cancer cell apoptosis. Here, we show that the HSP90 inhibitor 17-AAG can induce the expression of GRP75, a member of heat shock protein 70 (HSP70) family, which, in turn...