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Morphine coordinates SST and PV interneurons in the prelimbic cortex to disinhibit pyramidal neurons and enhance reward

Opioids, such as morphine, are clinic analgesics which induce euphoria. Morphine exposure modifies the excitability and functional interactions between neurons, while the underlying cellular and molecular mechanisms, especially how morphine assembles heterogeneous interneurons (INs) in prelimbic cortex (PrL) to mediate disinhibition and reward, are not clear. Using approaches of...

MiR-218 targets MeCP2 and inhibits heroin seeking behavior

, Institutes of Brain Science and The Collaborative Innovation Center for Brain Science, Fudan University, 138 Yixueyuan Road, Shanghai 200032, ChinaBiao Yan, Zhaoyang Hu, Wenqing Yao, Qiumin Le, Bo Xu, Xing Liu ... Research journals • PubMed • Google ScholarSearch for Qiumin Le in:Nature Research journals • PubMed • Google ScholarSearch for Bo Xu in:Nature Research journals • PubMed • Google ScholarSearch for Xing Liu

GRK6 regulates ROS response and maintains hematopoietic stem cell self-renewal

G protein-coupled receptor kinases (GRKs) are critically involved in immune response through regulation of cytokine receptors in mature leukocytes, but their role in hematopoiesis is largely unknown. Here, we demonstrate that GRK6 knockout (GRK6−/−) mice exhibit lymphocytopenia, loss of the hematopoietic stem cell (HSC) and multiple progenitor populations. GRK6 deficiency leads...

Astroglial β-Arrestin1-mediated Nuclear Signaling Regulates the Expansion of Neural Precursor Cells in Adult Hippocampus

200032, ChinaYezheng Tao, Li Ma, Zhaohui Liao, Qiumin Le, Jialing Yu, Xing Liu, Haohong Li, Yuejun Chen, Ping Zheng, Zhengang Yang & Lan Ma AuthorsSearch for Yezheng Tao in:Nature Research journals ... • PubMed • Google ScholarSearch for Li Ma in:Nature Research journals • PubMed • Google ScholarSearch for Zhaohui Liao in:Nature Research journals • PubMed • Google ScholarSearch for Qiumin Le in:Nature