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15 papers found.
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Structural changes in renal arterioles in Type I diabetic patients

Aims/hypothesis. We aimed to obtain data on arteriolar structure in a follow-up study of microalbuminuric diabetic patients. Methods. Kidney biopsies were obtained at baseline and after 8 years in 18 Type I (insulin-dependent) diabetic patients. Albumin excretion rate, blood pressure and HbA1C were measured regularly, and the glomerular filtration rate (GFR) was measured at the...

Glomerular structural changes in Type 1 (insulin-dependent) diabetes mellitus: causes, consequences, and prevention

SummaryDiabetic nephropathy is caused primarily by advanced glomerulopathy, the renal expression of diabetic microangiopathy. With stereological methods a quantitative description of the structural changes is achieved. The glomerulopathy is characterized by an increase in basement membrane material: thickening of the capillary wall and an increase in mesangial volume relative to...

Kidney function and glomerulopathy over 8 years in young patients with Type I (insulin-dependent) diabetes mellitus and microalbuminuria

Aims/hypothesis We aimed to investigate prospectively the interrelation between kidney function and glomerular morphological changes over 8 years in young patients with Type I (insulin-dependent) diabetes mellitus and microalbuminuria. Methods Kidney biopsies were taken at baseline and after 8 years in 18 subjects who were 20 years of age (19–29 mean and range), had duration of...

Effect of angiotensin converting enzyme inhibitor or beta blocker on glomerular structural changes in young microalbuminuric patients with Type I (insulin-dependent) diabetes mellitus

Aims/hypothesis. To investigate the influence of angiotensin converting enzyme inhibitors and beta blockers on the progression of early diabetic glomerulopathy. Methods. Thirteen patients with Type I (insulin-dependent) diabetes mellitus (mean age 18.8 years) with microalbuminuria 31 (19–160) μg/min were randomised to treatment with enalapril (group 1, n = 7) or metoprolol (group...

Effect of octreotide and insulin on manifest renal and glomerular hypertrophy and urinary albumin excretion in long-term experimental diabetes in rats

SummaryTreatment of diabetic rats with octreotide can inhibit early diabetic renal hypertrophy. Octreotide administration for 6 months from the day of diabetes induction inhibits renal hypertrophy and diminishes increase in urinary albumin excretion. To investigate the effect of octreotide on manifest diabetic renal changes, octreotide treatment was given for 3 weeks after an...

Glomerular ultrastructure in kidneys transplanted simultaneously with a segmental pancreas to patients with type 1 diabetes

Background. Pancreas transplantation has been reported to prevent development and progression of diabetic glomerulopathy. Study design. Kidneys transplanted to type 1 diabetic patients were investigated for signs of diabetic glomerulopathy. Biopsies were obtained from 11 patients 2–4 years after simultaneous pancreas and kidney transplantation and from six patients 2–6 years...

Kidney transplantation in Type 1 (insulin-dependent) diabetic patients

SummaryThe development of diabetic glomerulopathy in kidneys transplanted to diabetic patients was estimated in transplant biopsies and evaluated in relation to suspected clinical risk factors for diabetic nephropathy. Surgical biopsies were taken at baseline and at 24–36 months post-transplantation in 16 Type 1 (insulin-dependent) diabetic patients and 8 non-diabetic control...

Morphometric studies of the peripheral glomerular basement membrane

SummaryGlomerular basement membrane thickness has been estimated by quantitative electron-microscopic study in control subjects and in juvenile diabetics at onset and with short-term diabetes. — The juxta-mesangial part of the basement membrane as well as basement membranes located close to the vascular pole were considered separately and their thickness compared with the...

Glomerular size and structure in diabetes mellitus

SummaryThe volume of the glomerular tuft and its components was estimated in juvenile diabetics at onset and after one to six years' duration of the disease. An enlargement of the glomerular tuft was demonstrated in the newly diagnosed diabetics. In these patients the volume of both the individual capillary lumina and of the individual glomerular cells was enlarged, whereas the...

Glomerular size and structure in diabetes mellitus. II. Late abnormalities

A study of autopsy kidney material from six long-term diabetics and four controls was performed in order to elucidate the mechanism of the glomerular enlargement in long-term diabetics. The volume and the severity of the glomerular lesion were measured in each of a number of randomly selected, open glomeruli. The relative amount of solid material was taken as an expression of the...

Early glomerulopathy is present in young, Type 1 (insulin-dependent) diabetic patients with microalbuminuria

Increased urinary albumin excretion, microalbuminuria, may be the first sign of early diabetic nephropathy. We examined glomeruli by morphometric methods in 17 patients with Type 1 (insulin-dependent) diabetes mellitus and microalbuminuria. The median age was 19 (range 18–29) years, duration of diabetes 12 (8–15) years, mean blood pressure 93 (87–115) mm Hg, glomerular filtration...

A strong correlation between glomerular filtration rate and filtration surface in diabetic nephropathy

SummaryQuantitative structural studies were performed in kidney biopsy specimens from 24 long-term Type 1 (insulin-dependent) diabetic patients with persistent albuminuria due to diabetic glomerulopathy. Ten patients were receiving antihypertensive treatment, and among the remaining patients the mean blood pressure was 142/91 mmHg (SD = 11/9). The urinary albumin excretion rate...

Early functional and morphologic vascular renal consequences of the diabetic state

Renal hyperfunction and hypertrophy are characteristic findings in the early diabetic state, both in diabetes mellitus and in experimental diabetes. A number of structure-function relationships and their likely mechanisms are discussed. The metabolically induced hypertrophy of glomerular capillaries possibly plays a central role. Its cause is not known, but recent results on its...

Glomerular size and structure in diabetes mellitus

The present electron microscopic study shows that the kidney hyperfunction in early diabetes can be due to a significant morphological change: an increased glomerular filtration surface. Applying standard stereological methods, the area of the peripheral wall of the glomerular capillaries was measured in biopsy specimens obtained from 7 patients with early diabetes and 7 controls...