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A high HIV-1 strain variability in London, UK, revealed by full-genome analysis: Results from the ICONIC project

Brown. Data curation: Jade Raffle, Jonathan Hubb, R. Bridget Ferns, Laura Waters, Zisis Kozlakidis, Andrew Hayward, Paul Kellam, Deenan Pillay, Duncan Clark, Eleni Nastouli. Formal analysis: Gonzalo ... , Jonathan Hubb, R. Bridget Ferns, Laura Waters, C. Y. William Tong, Zisis Kozlakidis, Andrew Hayward, Paul Kellam, Deenan Pillay, Duncan Clark, Eleni Writing ± original draft: Gonzalo Yebra, Andrew J. Leigh

Proof-of-Principle for Immune Control of Global HIV-1 Reactivation In Vivo

Background. Emerging data relating to human immunodeficiency virus type 1 (HIV-1) cure suggest that vaccination to stimulate the host immune response, particularly cytotoxic cells, may be critical to clearing of reactivated HIV-1–infected cells. However, evidence for this approach in humans is lacking, and parameters required for a vaccine are unknown because opportunities to...