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Bioactive Components of the Traditionally used Mushroom Podaxis pistillaris

In the course of an ethnobotanical study on fungi used in Yemeni ethnomedicine the fungus Podaxis pistillaris (Podaxales, Podaxaceae, Basidiomycetes) was found to exhibit antibacterial activity against Staphylococcus aureus, Micrococcus flavus, Bacillus subtilis, Proteus mirabilis, Serratia marcescens and Escherichia coli. In the culture medium of P. pistillaris three...

Longitudinal echocardiographic and clinical follow-up of patients undergoing mitral valve surgery without concomitant tricuspid valve repair

repair in this specific patient cohort. KeywordsTricuspid valve repair Functional tricuspid regurgitation Mitral valve surgery Mitral valve aetiology  The Authors R. Jansen and B.R. van Klarenbosch

Estimating mean circulatory filling pressure in clinical practice: a systematic review comparing three bedside methods in the critically ill

The bedside hemodynamic assessment of the critically ill remains challenging since blood volume, arterial–venous interaction and compliance are not measured directly. Mean circulatory filling pressure (Pmcf) is the blood pressure throughout the vascular system at zero flow. Animal studies have shown Pmcf provides information on vascular compliance, volume responsiveness and...

Evaluation of mitral regurgitation by an integrated 2D echocardiographic approach in patients undergoing transcatheter aortic valve replacement

The purpose of this study was to evaluate mitral regurgitation (MR) severity in patients undergoing transcatheter aortic valve replacement (TAVR) by standardized assessment of two-dimensional (2D) transthoracic echocardiography (TTE) and 1-year echocardiographic and clinical outcomes. Pre- and post-procedural TTE’s of patients undergoing TAVR between 2008 and 2014 were analyzed...

Serum proteomic profiles of depressive subtypes

Depression is a highly heterogeneous disorder. Accumulating evidence suggests biological and genetic differences between subtypes of depression that are homogeneous in symptom presentation. We aimed to evaluate differences in serum protein profiles between persons with atypical and melancholic depressive subtypes, and compare these profiles with serum protein levels of healthy...

Febrile neutropenia: significance of elaborated screening for respiratory viruses, and the comparison of different sampling methods, in neutropenic patients with hematological malignancies

Background During febrile neutropenia in only 30 to 60 percent an infectious agent is identified. This diagnostic gap could hypothetically be reduced with the broad implementation of molecular detection techniques like PCR, which has revolutionized the detection of infectious diseases during the last two decades. Findings We performed a longitudinal prospective study (N = 81) of...

Estimation of mean systemic filling pressure in postoperative cardiac surgery patients with three methods

Jacinta J. Maas Michael R. Pinsky Bart F. Geerts Rob B. de Wilde Jos R. Jansen 0 1 0 B. F. Geerts Department of Anesthesiology, Leiden University Medical Center , Leiden, The Netherlands 1 M. R

The role of exercise echocardiography in the management of mitral valve disease

Purpose Exercise echocardiography can assess the dynamic component of mitral valve (MV) disease and may therefore be helpful for the clinical decision-making by the heart team. The purpose of this study is to determine the role of exercise echocardiography in the management of disproportionately symptomatic or otherwise atypical patients with mitral regurgitation (MR) and...

Molecular Epidemiology and Evolution of Human Respiratory Syncytial Virus and Human Metapneumovirus

Human respiratory syncytial virus (HRSV) and human metapneumovirus (HMPV) are ubiquitous respiratory pathogens of the Pneumovirinae subfamily of the Paramyxoviridae. Two major surface antigens are expressed by both viruses; the highly conserved fusion (F) protein, and the extremely diverse attachment (G) glycoprotein. Both viruses comprise two genetic groups, A and B. Circulation...

Targeted manipulation of the sortilin–progranulin axis rescues progranulin haploinsufficiency

Progranulin (GRN) mutations causing haploinsufficiency are a major cause of frontotemporal lobar degeneration (FTLD-TDP). Recent discoveries demonstrating sortilin (SORT1) is a neuronal receptor for PGRN endocytosis and a determinant of plasma PGRN levels portend the development of enhancers targeting the SORT1–PGRN axis. We demonstrate the preclinical efficacy of several...

A tool for tracking visual attention: The Restricted Focus Viewer

addressed to A. R. Jansen, School of Computer Science and Software Engineering, Monash University, VIC 3800, Australia (e-mail: ). pense: Typically, the better the resolution accuracy and sampling rate, the

Midtrimester preterm prelabour rupture of membranes (PPROM): expectant management or amnioinfusion for improving perinatal outcomes (PPROMEXIL – III trial)

Augustinus S P van Teeffelen 0 David P van der Ham Christine Willekes 0 Salwan Al Nasiry 0 Jan G Nijhuis 0 Sander van Kuijk Ewoud Schuyt Twan L M Mulder Maureen T M Franssen Dick Oepkes Fenna A R ... Jansen Mallory D Woiski Mireille N Bekker Caroline J Bax Martina M Porath Monique W M de Laat Ben W Mol Eva Pajkrt 0 Department of Obstetrics and Gynaecology, GROW - School for Oncology and Developmental

An isoform of the vacuolar (H+)-ATPase accessory subunit Ac45

The vacuolar (H+)-ATPase (V-ATPase) is the main regulator of intraorganellar pH and in neuroendocrine cells is controlled by its accessory subunit, Ac45. Here, we report the discovery of the first isoform of a V-ATPase accessory subunit, namely an Ac45-like protein, denoted Ac45LP. Phylogenetic analysis revealed a lineage-dependent evolutionary history: Ac45 is absent in birds...

Azole-Resistant Central Nervous System Aspergillosis

Three patients with central nervous system aspergillosis due to azole-resistant Aspergillus fumigatus (associated with a leucine substitution for histidine at codon 98 [L98H] and a 34–base pair repeat in tandem in the promoter region) are described. The patients were treated with combination therapy or with polyenes, but all patients died. Azole resistance significantly...

The Promises of Art Appreciation: The Foundations of Aesthetic Education

A history of appreciation could quickly multiply into a collection of histories, some tracing theories of appreciation as a phenomenon of mind and some tracing appreciation as a pedagogical subject or goal. In order to limit the directions a history of appreciation could take, this paper assumes that art appreciation in pedagogy encompasses and reflects various theories of art...

BRAIN GROWTH FOLLOWING WHEAT PROTEIN SUPPLEMENTATION

The supplementation of wheat with its limiting amino acids, lysine (1ys) and threonine (threo) has been shown to improve the growth of children receiving low protein diets. If supplementation also improves brain growth, it might provide a strong argument for routine amino acid addition.In the present study, 3 pregnant rats were given one of 3 diets: A) bread only, B) bread + lys...

MEDICAL RADIATION THERAPIES

We assessed the clinical features and treatment outcome in immunocompetent patients of primary central nervous system lymphoma (PCNSL) by retrospective chart review from 2005–12. Overall survival was analyzed by Kaplan-Meier method. 17 patients met the study criterion (male: female = 11:6). Median age at presentation was 47 years (range 15–74 years). Presenting features included...