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Cholesterol contributes to dopamine-neuronal loss in MPTP mouse model of Parkinson’s disease: Involvement of mitochondrial dysfunctions and oxidative stress

Hypercholesterolemia is a known contributor to the pathogenesis of Alzheimer’s disease while its role in the occurrence of Parkinson’s disease (PD) is only conjecture and far from conclusive. Altered antioxidant homeostasis and mitochondrial functions are the key mechanisms in loss of dopaminergic neurons in the substantia nigra (SN) region of the midbrain in PD...

Evaluation of antioxidant activity and total phenol in different varieties of Lantana camara leaves

BackgroundPhytochemicals like carotenoids, tocopherols, ascorbates and phenols present in the plants are strong antioxidants and have an important role in the health care system. There is growing interest in correlating the phytochemical constituents of a plant with its pharmacological activity. Therefore, the present study investigates the content of total phenolics, flavonoids...

Identification of Guanosine 5′-diphosphate as Potential Iron Mobilizer: Preventing the Hepcidin-Ferroportin Interaction and Modulating the Interleukin-6/Stat-3 Pathway

• Google ScholarSearch for Geeta Shukla in:Nature Research journals • PubMed • Google ScholarSearch for Rajat Sandhir in:Nature Research journals • PubMed • Google ScholarSearch for Vikas Rishi in:Nature ... under the supervision of Prof. Rajat Sandhir. The article is written by Stanzin Angmo, Neha Tripathi, Sheenu Abbat, Prof. P.V. Bharatam, Dr. Hariom Yadav and Dr. Nitin Kumar Singhal. Competing interests

Capsaicin Induces “Brite” Phenotype in Differentiating 3T3-L1 Preadipocytes

Objective Targeting the energy storing white adipose tissue (WAT) by pharmacological and dietary means in order to promote its conversion to energy expending “brite” cell type holds promise as an anti-obesity approach. Present study was designed to investigate/revisit the effect of capsaicin on adipogenic differentiation with special reference to induction of “brite” phenotype...