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Steroid Receptor Coactivator-2 Controls the Pentose Phosphate Pathway through RPIA in Human Endometrial Cancer Cells

, USAFrancesco J. DeMayo AuthorsSearch for Maria M. Szwarc in:Nature Research journals • PubMed • Google Scholar Search for Ramakrishna Kommagani in:Nature Research journals • PubMed • Google Scholar Search for

A bioluminescence reporter mouse that monitors expression of constitutively active β-catenin

This short technical report describes the generation and characterization of a bioluminescence reporter mouse that is engineered to detect and longitudinally monitor the expression of doxycycline-induced constitutively active β-catenin. The new responder transgenic mouse contains the TetO-ΔN89β-CatTMILA transgene, which consists of the tet-operator followed by a bicistronic...

Aberrant Activation of the RANK Signaling Receptor Induces Murine Salivary Gland Tumors

Unlike cancers of related exocrine tissues such as the mammary and prostate gland, diagnosis and treatment of aggressive salivary gland malignancies have not markedly advanced in decades. Effective clinical management of malignant salivary gland cancers is undercut by our limited knowledge concerning the key molecular signals that underpin the etiopathogenesis of this rare and...

Perturbing the Cellular Levels of Steroid Receptor Coactivator-2 Impairs Murine Endometrial Function

As pleiotropic coregulators, members of the p160/steroid receptor coactivator (SRC) family control a broad spectrum of transcriptional responses that underpin a diverse array of physiological and pathophysiological processes. Because of their potent coregulator properties, strict controls on SRC expression levels are required to maintain normal tissue functionality. Accordingly...

Acceleration of the Glycolytic Flux by Steroid Receptor Coactivator-2 Is Essential for Endometrial Decidualization

Early embryo miscarriage is linked to inadequate endometrial decidualization, a cellular transformation process that enables deep blastocyst invasion into the maternal compartment. Although much of the cellular events that underpin endometrial stromal cell (ESC) decidualization are well recognized, the individual gene(s) and molecular pathways that drive the initiation and...

Differential effects of p63 mutants on transactivation of p53 and/or p63 responsive genes

p63, known to play a role in development, has more recently also been implicated in cancer progression. Mutations in p63 have been shown to be responsible for several human developmental diseases. Differential splicing of the p63 gene gives rise to p63 isoforms, which can act either as tumor suppressors or as oncogene. In this report, we studied the effects of naturally occurring...

Pediatrics Laboratory Research

MEDULLOBLASTOMA CELLS TO ETOPOSIDE-MEDIATED APOPTOSIS Chandra M. Das 1, Pete Taylor 1, Xiaohua Su 1, Ramakrishna Kommagani 2, Dolly G. Aguilera 1, Johannes E. Wolff 1, Madhavi P. Kadakia 2, Elsa R. Flores 1, and