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Development and characterization of a novel luciferase based cytotoxicity assay

Hittu Matta, Ramakrishnan Gopalakrishnan and Sunju Choi contributed equally to this work. AffiliationsJane Anne Nohl Division of Hematology and Center for the Study of Blood Diseases, University of ... Southern California, Keck School of Medicine, Los Angeles, California, United States of AmericaHittu Matta, Ramakrishnan Gopalakrishnan, Sunju Choi, Rekha Prakash, Venkatesh Natarajan, Ruben Prins, Songjie

Kaposi’s Sarcoma Associated Herpesvirus Encoded Viral FLICE Inhibitory Protein K13 Activates NF-κB Pathway Independent of TRAF6, TAK1 and LUBAC

Background Kaposi’s sarcoma associated herpesvirus encoded viral FLICE inhibitory protein (vFLIP) K13 activates the NF-κB pathway by binding to the NEMO/IKKγ subunit of the IκB kinase (IKK) complex. However, it has remained enigmatic how K13-NEMO interaction results in the activation of the IKK complex. Recent studies have implicated TRAF6, TAK1 and linear ubiquitin chains...