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Gut microbiota and butyrate level changes associated with the long-term administration of proton pump inhibitors to old rats

The association between adverse effects of PPI and gut microbiota in old age has yet to be elucidated. We assessed changes in the gut microbiota and butyrate levels following the long-term administration of PPIs to old rats and investigated their associations. F344 aged male rats were fed a PPI-supplemented diet for 50 weeks. The ileal microbiota was analysed by metagenomic...

Class I histone deacetylase inhibitor MS-275 attenuates vasoconstriction and inflammation in angiotensin II-induced hypertension

. (TIF) Author Contributions Conceptualization: Hae Jin Kee. Data curation: Yuhee Ryu, Young Mi Seok, Gwi Ran Kim, Hyung-Seok Kim. Formal analysis: Yuhee Ryu, Hae Jin Kee, Young Mi Seok, Seung-Jung Kee

A novel taping therapy for pain after arthroscopic shoulder surgery: study protocol for a randomised controlled pilot trial

In recent years, the number of arthroscopic shoulder surgeries has increased given that the intervention is minimally invasive. However, postoperative pain is one of the most common symptoms of patients who undergo arthroscopic surgery. Although pharmacological treatments and brachial plexus blocks for reducing pain are currently used, the adherence rate of interventions is low...

Gallic acid improves cardiac dysfunction and fibrosis in pressure overload-induced heart failure

National University Hospital, Gwangju, 61469, Republic of KoreaLi Jin, Simei Sun, Yuhee Ryu, Sin Young Choi, Gwi Ran Kim, Hae Jin Kee & Myung Ho JeongZhengjiang Rongjun Hospital, 352 Zhongshan road, Jiaxing ... Center, Chonnam National University Hospital, Gwangju, 61469, Republic of KoreaSimei Sun, Yuhee Ryu, Sin Young Choi, Gwi Ran Kim, Hae Jin Kee & Myung Ho JeongThe Second Hospital of Jilin University

Association of genetic variations with pharmacokinetics and lipid-lowering response to atorvastatin in healthy Korean subjects

Association of genetic variations with pharmacokinetics and lipid-lowering response to atorvastatin in healthy Korean subjects Hye In Woo,1 Suk Ran Kim,2 Wooseong Huh,3,4 Jae-Wook Ko,4 Soo-Youn ... Woo 1 suk ran Kim 2 Wooseong huh 3,4 ABCC2 Introduction As therapeutic agents administered to reduce the risk of cardiovascular disease and manage hypercholesterolemia,1 statins upregulate low

The general PTS component HPr determines the preference for glucose over mannitol

Preferential sugar utilization is a widespread phenomenon in biological systems. Glucose is usually the most preferred carbon source in various organisms, especially in bacteria where it is taken up via the phosphoenolpyruvate:sugar phosphotransferase system (PTS). The currently proposed model for glucose preference over non-PTS sugars in enteric bacteria including E. coli is...

Effects of Pyrogallol on Growth and Cytotoxicity of Wild-Type and katG Mutant Strains of Vibrio vulnificus

Vibrio vulnificus is a causative agent of fatal septicemia and necrotic wound infection and the pathogen infection became an important public health problem in many counties. Vibrio vulnificus causes RtxA1 toxin-induced acute cell death. We tried to identify natural products that inhibit the acute cytotoxicity of V. vulnificus using a lactate hydrogenase assay. A polyphenol...

Measurements of 6-thioguanine nucleotide levels with TPMT and NUDT15 genotyping in patients with Crohn’s disease

curation: Ji Hyeon Lee, Tae Jun Kim, Eun Ran Kim. Formal analysis: Ji Hyeon Lee, Tae Jun Kim, Eun Ran Kim, Sung Noh Hong, Li-Hwa Choi, Hye In Woo. Funding acquisition: Young-Ho Kim. Investigation: Hye In ... Woo. Methodology: Eun Ran Kim, Dong Kyung Chang, Li-Hwa Choi, Hye In Woo, Soo-Youn Lee. Resources: Young-Ho Kim. Supervision: Dong Kyung Chang, Soo-Youn Lee, Young-Ho Kim. Validation: Sung Noh Hong

Gallic Acid Reduces Blood Pressure and Attenuates Oxidative Stress and Cardiac Hypertrophy in Spontaneously Hypertensive Rats

Gallic acid (GA) has been reported to have beneficial effects on cancer, vascular calcification, and diabetes-induced myocardial dysfunction. We hypothesized that GA controls hypertension via oxidative stress response regulation in an animal model for essential hypertension. Spontaneously hypertensive rats (SHRs) were administered GA for 16 weeks. GA treatment lowered elevated...

Single nucleotide polymorphisms at miR-146a/196a2 and their primary ovarian insufficiency-related target gene regulation in granulosa cells

Cho, Woo Sik Lee, Nam Keun Kim. Formal analysis: Sung Hwan Cho, Hui Jeong An, Kyung Ah Kim, Ji Hyang Kim, Young Ran Kim. Funding acquisition: Nam Keun Kim. Methodology: Hui Jeong An, Kyung Ah Kim ... , HyungChul Rah. Resources: Ji Hyang Kim, Young Ran Kim, Eun Hee Ahn, HyungChul Rah. Validation: Sung Hwan Cho. Visualization: Sung Hwan Cho. Writing ± original draft: Sung Hwan Cho, Jung Jae Ko, Woo Sik Lee

Long-term PGC1β overexpression leads to apoptosis, autophagy and muscle wasting

Medical School, Houston, TX, 77030, USADanesh H. Sopariwala, Vikas Yadav, Pierre-Marie Badin, Neah Likhite, Megha Sheth, Sabina Lorca, Eun Ran Kim, Qingchun Tong & Vihang A. NarkarDepartment of Biochemistry ... Search for Sabina Lorca in:Nature Research journals • PubMed • Google Scholar Search for Isabelle K. Vila in:Nature Research journals • PubMed • Google Scholar Search for Eun Ran Kim in:Nature Research

An Essential Role for TAGLN2 in Phagocytosis of Lipopolysaccharide-activated Macrophages

), Korea, and the GIST Research Institute (GRI) in 2017. Author information AffiliationsSchool of Life Sciences, Gwangju, 500-712, KoreaHye-Ran Kim, Hyun-Su Lee, Kyung-Sik Lee, Min-Sung Kwon, Chang-Hyun ... Kim & Chang-Duk JunImmune Synapse and Cell Therapy Research Center, GIST, Gwangju, 500-712, KoreaHye-Ran Kim, Hyun-Su Lee, Kyung-Sik Lee, Min-Sung Kwon, Chang-Hyun Kim & Chang-Duk JunSchool of Materials

An Indirect Action Contributes to C-Fos Induction in Paraventricular Hypothalamic Nucleus by Neuropeptide Y

Neuropeptide Y (NPY) is a well-established orexigenic peptide and hypothalamic paraventricular nucleus (PVH) is one major brain site that mediates the orexigenic action of NPY. NPY induces abundant expression of C-Fos, an indicator for neuronal activation, in the PVH, which has been used extensively to examine the underlying NPY orexigenic neural pathways. However, PVH C-Fos...

Therapeutic Potential of Stem Cells Strategy for Cardiovascular Diseases

after CVDs. Competing Interests The authors report no conflict of interests in this work. Authors’ Contributions Chang Youn Lee, Ran Kim, and Onju Ham contributed equally to this work. Acknowledgments

HerDing: herb recommendation system to treat diseases using genes and chemicals

In recent years, herbs have been researched for new drug candidates because they have a long empirical history of treating diseases and are relatively free from side effects. Studies to scientifically prove the medical efficacy of herbs for target diseases often spend a considerable amount of time and effort in choosing candidate herbs and in performing experiments to measure...

Larvicidal activity and possible mode of action of four flavonoids and two fatty acids identified in Millettia pinnata seed toward three mosquito species

Background Aedes aegypti and Aedes albopictus and Culex pipiens pallens mosquitoes transmit dengue fever and West Nile virus diseases, respectively. This study was conducted to determine the toxicity and mechanism of action of four flavonoids and two fatty acids from Millettia pinnata (Fabaceae) seed as well as six pure fatty acids and four fatty acid esters toward third instar...