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Early impairment of intracranial conduction time predicts mortality in deeply sedated critically ill patients: a prospective observational pilot study

Raphael Porcher Tarek Sharshar 0 0 General Intensive Care Medicine, Raymond Poincaré Hospital (AP‐HP), University of Versailles Saint‐ Quentin en Yvelines , 104, Boulevard Raymond Poincaré, 92380 Garches

Impact of an online writing aid tool for writing a randomized trial report: the COBWEB (Consort-based WEB tool) randomized controlled trial

Background Incomplete reporting is a frequent waste in research. Our aim was to evaluate the impact of a writing aid tool (WAT) based on the CONSORT statement and its extension for non-pharmacologic treatments on the completeness of reporting of randomized controlled trials (RCTs). Methods We performed a ‘split-manuscript’ RCT with blinded outcome assessment. Participants were...

Impact of an online writing aid tool for writing a randomized trial report: the COBWEB (Consort-based WEB tool) randomized controlled trial

Incomplete reporting is a frequent waste in research. Our aim was to evaluate the impact of a writing aid tool (WAT) based on the CONSORT statement and its extension for non-pharmacologic treatments on the completeness of reporting of randomized controlled trials (RCTs). We performed a ‘split-manuscript’ RCT with blinded outcome assessment. Participants were masters and doctoral...

Relationship between Fungal Colonisation of the Respiratory Tract in Lung Transplant Recipients and Fungal Contamination of the Hospital Environment

Background Aspergillus colonisation is frequently reported after lung transplantation. The question of whether aspergillus colonisation is related to the hospital environment is crucial to prevention. Method To elucidate this question, a prospective study of aspergillus colonisation after lung transplantation, along with a mycological survey of the patient environment, was...

Brainstem response patterns in deeply-sedated critically-ill patients predict 28-day mortality

Background and purpose Deep sedation is associated with acute brain dysfunction and increased mortality. We had previously shown that early-assessed brainstem reflexes may predict outcome in deeply sedated patients. The primary objective was to determine whether patterns of brainstem reflexes might predict mortality in deeply sedated patients. The secondary objective was to...

Could Digital PCR Be an Alternative as a Non-Invasive Prenatal Test for Trisomy 21: A Proof of Concept Study

Objective NIPT for fetal aneuploidy by digital PCR has been hampered by the large number of PCR reactions needed to meet statistical requirements, preventing clinical application. Here, we designed an octoplex droplet digital PCR (ddPCR) assay which allows increasing the number of available targets and thus overcomes statistical obstacles. Method After technical optimization of...

ADC Histograms from Routine DWI for Longitudinal Studies in Cerebral Small Vessel Disease: A Field Study in CADASIL

Diffusion tensor imaging (DTI) histogram metrics are correlated with clinical parameters in cerebral small vessel diseases (cSVD). Whether ADC histogram parameters derived from simple diffusion weighted imaging (DWI) can provide relevant markers for long term studies of cSVD remains unknown. CADASIL patients were evaluated by DWI and DTI in a large cohort study overa6-year period...

Response Assessment in Invasive Aspergillosis

disclosed. Anne Bergeron,1 Raphael Porcher,2 Emmanuel Raffoux,3 Annie Sulahian,4 and Patricia Ribaud5 1Service de Pneumologie, 2Dpartement de Biostatistiques, 3Service des Maladies du Sang; 4Parasitologie

Early Standard Electroencephalogram Abnormalities Predict Mortality in Septic Intensive Care Unit Patients

Introduction Sepsis is associated with increased mortality, delirium and long-term cognitive impairment in intensive care unit (ICU) patients. Electroencephalogram (EEG) abnormalities occurring at the acute stage of sepsis may correlate with severity of brain dysfunction. Predictive value of early standard EEG abnormalities for mortality in ICU septic patients remains to be...

Thirst Perception and Osmoregulation of Vasopressin Secretion Are Altered During Recovery From Septic Shock

ObjectiveVasopressin (AVP) secretion during an osmotic challenge is frequently altered in the immediate post-acute phase of septic shock. We sought to determine if this response is still altered in patients recovering from septic shock. DesignProspective interventional study SettingIntensive care unit (ICU) at Raymond Poincaré and Etampes Hospitals. PatientsNormonatremic patients...

A Prospective Study of Bone Marrow Hematopoietic and Mesenchymal Stem Cells in Type 1 Gaucher Disease Patients

Gaucher disease (GD) is an autosomal recessive disorder characterized by lysosomal glucocerebrosidase (GBA) deficiency leading to hematological and skeletal manifestations. Mechanisms underlying these symptoms have not yet been elucidated. In vivo, bone marrow (BM) mesenchymal stem cells (MSCs) have important role in the regulation of bone mass and in the support of hematopoiesis...

β- and α-Cell Dysfunctions in Africans With Ketosis-Prone Atypical Diabetes During Near-Normoglycemic Remission

SIMON-PIERRE CHOUKEM EUGENE SOBNGWI PHD PHILIPPE BOUDOU PHD LILA-SABRINA FETITA RAPHAEL PORCHER PHD FIDAA IBRAHIM OBJECTIVEdKetosis-prone atypical diabetes (KPD) is a subtype of diabetes in which

Long-Term Impact of a Multifaceted Prevention Program on Ventilator-Associated Pneumonia in a Medical Intensive Care Unit

Background. Ventilator-associated pneumonia (VAP), the most common hospital-acquired infection in intensive care units, increases mortality and health care costs. We describe the long-term impact of a multifaceted program for decreasing VAP rates that markedly improved compliance with 8 targeted preventive measures. Methods. We compared VAP rates during a 45-month baseline period...

Hyperglycaemia and apoptosis of microglial cells in human septic shock

Introduction The effect of hyperglycaemia on the brain cells of septic shock patients is unknown. The objective of this study was to evaluate the relationship between hyperglycaemia and apoptosis in the brains of septic shock patients. Methods In a prospective study of 17 patients who died from septic shock, hippocampal tissue was assessed for neuronal ischaemia, neuronal and...

Soluble Isoforms of Vascular Endothelial Growth Factor Are Predictors of Response to Sunitinib in Metastatic Renal Cell Carcinomas

Background Angiogenesis is the target of several agents in the treatment of malignancies, including renal cell carcinoma (RCC). There is a real need for surrogate biomarkers that can predict selection of patients who may benefit from antiangiogenic therapies, prediction of disease outcome and which may improve the knowledge regarding mechanism of action of these treatments...

Fetal Exposure to Maternal Type 1 Diabetes Is Associated With Renal Dysfunction at Adult Age

Charbel Abi Khalil Florence Travert Sabrina Fetita Fran cois Rouzet Raphael Porcher Jean-Pierre Riveline Samy Hadjadj Etienne Larger Ronan Roussel Patrick Vexiau Dominique Le Guludec Jean-Fran cois

Palivizumab Treatment of Respiratory Syncytial Virus Infection after Allogeneic Hematopoietic Stem Cell Transplantation

Flore Sicre de Fontbrune Marie Robin Raphael Porcher Catherine Scieux Re gis Peffault de Latour Christe` le Ferry Vanderson Rocha Karim Boudjedir Agne` s Devergie Anne Bergeron Eliane Gluckman Elie

Temporal Dynamics of Interferon Gamma Responses in Children Evaluated for Tuberculosis

Background Development of T-cells based-Interferon gamma (IFNγ) assays has offered new possibilities for the diagnosis of latent tuberculosis infection (LTBI) and active disease in adults. Few studies have been performed in children, none in France. With reference to the published data on childhood TB epidemiology in the Paris and Ile de France Region, we considered it important...