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Search: authors:"Rebecca L. Brocato"

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Three asymptomatic animal infection models of hemorrhagic fever with renal syndrome caused by hantaviruses

manuscript. Conceptualization: Casey C. Perley, Rebecca L. Brocato, Jay W. Hooper. Formal analysis: Casey C. Perley, Rebecca L. Brocato, Steven A. Kwilas, Sharon Daye, Alicia Moreau, Donald K. Nichols, Jay W ... . Hooper. Funding acquisition: Casey C. Perley, Rebecca L. Brocato, Jay W. Hooper. Investigation: Casey C. Perley, Rebecca L. Brocato, Steven A. Kwilas, Sharon Daye, Alicia Moreau, Donald K. Nichols

Antiviral Biologic Produced in DNA Vaccine/Goose Platform Protects Hamsters Against Hantavirus Pulmonary Syndrome When Administered Post-exposure

Andes virus (ANDV) and ANDV-like viruses are responsible for most hantavirus pulmonary syndrome (HPS) cases in South America. Recent studies in Chile indicate that passive transfer of convalescent human plasma shows promise as a possible treatment for HPS. Unfortunately, availability of convalescent plasma from survivors of this lethal disease is very limited. We are interested...

Pichinde virus induces microvascular endothelial cell permeability through the production of nitric oxide

This report is the first to demonstrate infection of human endothelial cells by Pichinde virus (PIC). PIC infection induces an upregulation of the inducible nitric oxide synthase gene; as well as an increase in detectable nitric oxide (NO). PIC induces an increase in permeability in endothelial cell monolayers which can be abrogated at all measured timepoints with the addition of...