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Expression and in vitro assessment of tumorigenicity for NOD1 and NOD2 receptors in breast cancer cell lines

. Correa 0 0 Sanford Burnham Prebys Medical Discovery Institute , 10901 North Torrey Pines Rd., La Jolla, CA 92037 , USA 1 Cell and Molecular Therapy Center (NUCEL-NETCEM), Internal Medicine Department

Expression and in vitro assessment of tumorigenicity for NOD1 and NOD2 receptors in breast cancer cell lines

Immune-related pathways have been frequently associated to tumorigenesis. NOD1 and NOD2 are innate immune receptors responsible for sensing a subset of bacterial-derived components, and to further translate these pathogenic signals through pro-inflammatory and survival pathways. NOD1 and NOD2 have been further associated with tumorigenesis, particularly in gastrointestinal...

The crossroads of breast cancer progression: insights into the modulation of major signaling pathways

The crossroads of breast cancer progression: insights into the modulation of major signaling pathways Fernando J Velloso,1,* Arthur FR Bianco,2,* Jessica O Farias,3 Nadia EC Torres,4 Pault YM Ferruzo,3 Valesca Anschau,5 Henrique C Jesus-Ferreira,1 Ted Hung-Tse Chang,6 Mari Cleide Sogayar,1 Luiz F Zerbini,6 Ricardo G Correa7 1Cell and Molecular Therapy Center (NUCEL-NETCEM...

Roles of Commensal Microbiota in Pancreas Homeostasis and Pancreatic Pathologies

FAPESP (São Paulo State Foundation for Research), CNPq (National Research Council), and CAPES (Federal Agency for Superior Education and Training) for the financial support. Ricardo G. Correa was supported

Roles of Commensal Microbiota in Pancreas Homeostasis and Pancreatic Pathologies

FAPESP (São Paulo State Foundation for Research), CNPq (National Research Council), and CAPES (Federal Agency for Superior Education and Training) for the financial support. Ricardo G. Correa was supported

Roles of Commensal Microbiota in Pancreas Homeostasis and Pancreatic Pathologies

FAPESP (São Paulo State Foundation for Research), CNPq (National Research Council), and CAPES (Federal Agency for Superior Education and Training) for the financial support. Ricardo G. Correa was supported

Cloning and characterization of a novel alternatively spliced transcript of the human CHD7 putative helicase

BackgroundThe CHD7 (Chromodomain Helicase DNA binding protein 7) gene encodes a member of the chromodomain family of ATP-dependent chromatin remodeling enzymes. Mutations in the CHD7 gene are found in individuals with CHARGE, a syndrome characterized by multiple birth malformations in several tissues. CHD7 was identified as a binding partner of PBAF complex (Polybromo and BRG...

Dissecting Major Signaling Pathways throughout the Development of Prostate Cancer

Prostate cancer (PCa) is one of the most common malignancies found in males. The development of PCa involves several mutations in prostate epithelial cells, usually linked to developmental changes, such as enhanced resistance to apoptotic death, constitutive proliferation, and, in some cases, to differentiation into an androgen deprivation-resistant phenotype, leading to the...

Interleukin-1 Receptor-Associated Kinase-2 (IRAK2) Is a Critical Mediator of Endoplasmic Reticulum (ER) Stress Signaling

Endoplasmic reticulum (ER) stress occurs when unfolded proteins accumulate in the lumen of the organelle, triggering signal transduction events that contribute either to cellular adaptation and recovery or alternatively to cellular dysfunction and death. ER stress has been implicated in numerous diseases. To identify novel modulators of ER stress, we undertook a siRNA library...

Combinatorial Effect of Non-Steroidal Anti-inflammatory Drugs and NF-κB Inhibitors in Ovarian Cancer Therapy

Effect of Non-Steroidal Anti-inflammatory Drugs and NF-kB Inhibitors in Ovarian Cancer Therapy Luiz F. Zerbini Rodrigo E. Tamura Ricardo G. Correa Akos Czibere Jason Cordeiro Manoj Bhasin Fernando M