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Epigenetics and the Developmental Origins of Inflammatory Bowel Diseases

Can J Gastroenterol Epigenetics and the developmental origins of inflammatory bowel diseases Richard Kellermayer r Kellermayer. epigenetics and the developmental origins of inflammatory bowel

Epigenetics and the Developmental Origins of Inflammatory Bowel Diseases

Can J Gastroenterol Epigenetics and the developmental origins of inflammatory bowel diseases Richard Kellermayer r Kellermayer. epigenetics and the developmental origins of inflammatory bowel

Pediatric Fecal Microbiota Transplantation

treatment modality for a spectrum of clinical disorders that arise from a dysregulated host microbiota. Disclosure Sabina Mir, Richard Kellermayer, and Ajay S. Gulati declare that they have no conflict of

Colonic Mucosal Epigenome and Microbiome Development in Children and Adolescents

Richard Kellermayer have made substantial contributions to conception and design, or acquisition of data, or analysis and interpretation of data; R. Alan Harris, Rajesh Shah, Emily B. Hollister, Rune Rose ... Tronstad, Nils Hovdenak, Reka Szigeti, and Richard Kellermayer have been involved in drafting the paper or revising it critically for important intellectual content; R. Alan Harris, Rajesh Shah, Emily B

Transcriptional Read-Through Induction Treatment Trial in Intestinal Failure Induced by an EpCAM Nonsense Mutation

Congenital tufting enteropathy (CTE) is a rare autosomal recessive diarrheal disorder where epithelial tufts can be present from the duodenum to the large intestine. CTE has been linked to mutations in the epithelial cell adhesion molecule gene (EpCAM) Sivagnanam et al. (2008). We recently reported the first case with a nonsense mutation in EpCAM Sivagnanam et al. (2010). Here...

Prenatal Methyl-Donor Supplementation Augments Colitis in Young Adult Mice

the nutritional developmental origins of IBD. - Funding: Richard Kellermayer was supported in part by the Broad Medical Research Program, the Broad Foundation (IBD-0252); the Child Health Research

Cellulose Supplementation Early in Life Ameliorates Colitis in Adult Mice

Decreased consumption of dietary fibers, such as cellulose, has been proposed to promote the emergence of inflammatory bowel diseases (IBD: Crohn disease [CD] and ulcerative colitis [UC]) where intestinal microbes are recognized to play an etiologic role. However, it is not known if transient fiber consumption during critical developmental periods may prevent consecutive...

Maternal methyl-donor supplementation induces prolonged murine offspring colitis susceptibility in association with mucosal epigenetic and microbiomic changes

Developmental epigenetic changes, such as DNA methylation, have been recognized as potential pathogenic factors in inflammatory bowel diseases, the hallmark of which is an exaggerated immune response against luminal microbes. A methyl-donor (MD) diet can modify DNA methylation at select murine genomic loci during early development. The components of the MDs are routinely...

Epigenetic maturation in colonic mucosa continues beyond infancy in mice

Monozygotic twin and other epidemiologic studies indicate that epigenetic processes may play an important role in the pathogenesis of inflammatory bowel diseases that commonly affect the colonic mucosa. The peak onset of these disorders in young adulthood suggests that epigenetic changes normally occurring in the colonic mucosa shortly before adulthood could be important...

Season of Conception in Rural Gambia Affects DNA Methylation at Putative Human Metastable Epialleles

Throughout most of the mammalian genome, genetically regulated developmental programming establishes diverse yet predictable epigenetic states across differentiated cells and tissues. At metastable epialleles (MEs), conversely, epigenotype is established stochastically in the early embryo then maintained in differentiated lineages, resulting in dramatic and systemic...

Dissecting Allele Architecture of Early Onset IBD Using High-Density Genotyping

Background The inflammatory bowel diseases (IBD) are common, complex disorders in which genetic and environmental factors are believed to interact leading to chronic inflammatory responses against the gut microbiota. Earlier genetic studies performed in mostly adult population of European descent identified 163 loci affecting IBD risk, but most have relatively modest effect sizes...

Epigenomic profiling indicates a role for DNA methylation in early postnatal liver development

The question of whether DNA methylation contributes to the stabilization of gene expression patterns in differentiated mammalian tissues remains controversial. Using genome-wide methylation profiling, we screened 3757 gene promoters for changes in methylation during postnatal liver development to test the hypothesis that developmental changes in methylation and expression are...