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Search: authors:"Riekelt H. Houtkooper"

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NAD+ metabolism as a target for metabolic health: have we found the silver bullet?

NAD+ has gone in and out of fashion within the scientific community a number of times since its discovery in the early 1900s. Over the last decade, NAD+ has emerged as a potential target for combatting metabolic disturbances and the mitochondrial dysfunction that is mediated through sirtuin (SIRT) enzymes. The beneficial metabolic effects of the NAD+/SIRT axis have triggered an...

Disorders of mitochondrial long-chain fatty acid oxidation and the carnitine shuttle

Mitochondrial fatty acid oxidation is an essential pathway for energy production, especially during prolonged fasting and sub-maximal exercise. Long-chain fatty acids are the most abundant fatty acids in the human diet and in body stores, and more than 15 enzymes are involved in long-chain fatty acid oxidation. Pathogenic mutations in genes encoding these enzymes result in a long...

Sirtuin activation as a therapeutic approach against inborn errors of metabolism

Protein acylation has emerged as a large family of post translational modifications in which an acyl group can alter the function of a wide variety of proteins, especially in response to metabolic stress. The acylation state is regulated through reversible acylation/deacylation. Acylation occurs enzymatically or non-enzymatically, and responds to acyl-CoA levels. Deacylation on...

Ethnic differences in metabolite signatures and type 2 diabetes: a nested case–control analysis among people of South Asian, African and European origin

Accumulation of metabolites may mark or contribute to the development of type 2 diabetes mellitus (T2D), but there is a lack of data from ethnic groups at high risk. We examined sphingolipids, acylcarnitines and amino acids, and their association with T2D in a nested case–control study among 54 South Asian Surinamese, 54 African Surinamese and 44 Dutch in the Netherlands. Plasma...

Ketones and inborn errors of metabolism: old friends revisited

Hospital, University Medical Centre Utrecht , Utrecht , The Netherlands 1 Laboratory Genetic Metabolic Diseases, Academic Medical Center , Meibergdreef 9, 1105 AZ Amsterdam , The Netherlands 2 Riekelt H ... . Houtkooper - During exercise fat and carbohydrates are the principal substrates that fuel aerobic ATP synthesis in human skeletal muscle. During low-intensity exercise, skeletal muscle relies predominantly

Obesity: New life for antidiabetic drugs

New life for antidiabetic drugs Riekelt H. Houtkooper Johan Auwerx Antidiabetic drugs that activate the protein PPAR? had a bright start but soon lost their appeal because of undesirable side ... . Altogether, Choi and colleagues? work heralds a new era of drug discovery, in which PPAR? activity could be rationally targeted to ameliorate diabetes and avoid side effects. ? Riekelt H. Houtkooper and Johan

Fatty acid oxidation flux predicts the clinical severity of VLCAD deficiency

Sander?M.?Houten Frits?A.?Wijburg A.?Christiaan?Blank Folkert?W.?Asselbergs Riekelt?H.?Houtkooper 0 Gepke?Visser 1 0 Department of Clinical Chemistry, Laboratory Genetic Metabolic Diseases, Academic

The metabolic footprint of aging in mice

Diseases, AMC, 1105 AZ Amsterdam, The NetherlandsSander M. HoutenCenter of Phenogenomics, EPFL, 1015 Lausanne, SwitzerlandCharles Thomas & Raphaël Doenlen AuthorsSearch for Riekelt H. Houtkooper in:Nature

Cardiomyocyte-Specific miRNA-30c Over-Expression Causes Dilated Cardiomyopathy

MicroRNAs (miRNAs) regulate many aspects of cellular function and their deregulation has been implicated in heart disease. MiRNA-30c is differentially expressed in the heart during the progression towards heart failure and in vitro studies hint to its importance in cellular physiology. As little is known about the in vivo function of miRNA-30c in the heart, we generated...