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The molecular biology and HPV drug responsiveness of cynomolgus macaque papillomaviruses support their use in the development of a relevant in vivo model for antiviral drug testing

, Andres Ma?nnik. Writing ? original draft: Eva-Maria Tombak. Writing ? review & editing: Andres Ma?nnik, Robert D. Burk, Roger Le Grand, Ene Ustav, Mart Ustav. 16 / 20 17 / 20 18 / 20 19 / 20 1. Bernard

Association of an intact E2 gene with higher HPV viral load, higher viral oncogene expression, and improved clinical outcome in HPV16 positive head and neck squamous cell carcinoma

. Anayannis, Nicolas F. Schlecht, Thomas J. Belbin, Thomas J. Ow, Duk M. Blakaj, Robert D. Burk, Sarah M. Leonard, Ciaran B. Woodman, Joanna L. Parish, Michael B. Prystowsky. Data curation: Nicole V ... . Anayannis, Nicolas F. Schlecht, Miriam Ben-Dayan, Thomas J. Belbin, Robert D. Burk, Joanna L. Parish. Formal analysis: Nicole V. Anayannis, Nicolas F. Schlecht, Miriam Ben-Dayan, Thomas J. Belbin, Robert D

T cell receptor repertoire among women who cleared and failed to clear cervical human papillomavirus infection: An exploratory proof-of-principle study

Kuhs, Shih-Wen Lin, Xing Hua, Mark Schiffman, Robert D. Burk, Ana Cecilia Rodriguez, Rolando Herrero, Christian C. Abnet, Neal D. Freedman, Ligia A. Pinto, David Hamm, Harlan Robins, Allan Hildesheim ... . Investigation: Krystle A. Lang Kuhs, Shih-Wen Lin, Xing Hua, Mark Schiffman, Robert D. Burk, Ana Cecilia Rodriguez, Rolando Herrero, Christian C. Abnet, Neal D. Freedman, Ligia A. Pinto, David Hamm, Harlan

Degradation of Human PDZ-Proteins by Human Alphapapillomaviruses Represents an Evolutionary Adaptation to a Novel Cellular Niche

In order to complete their life cycle, papillomaviruses have evolved to manipulate a plethora of cellular pathways. The products of the human Alphapapillomavirus E6 proteins specifically interact with and target PDZ containing proteins for degradation. This viral phenotype has been suggested to play a role in viral oncogenesis. To analyze the association of HPV E6 mediated PDZ...

Human Papillomavirus 16 Non-European Variants Are Preferentially Associated with High-Grade Cervical Lesions

funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Competing Interests: Dr. Robert D. Burk is one of the co-authors and he is a PLOS

Lactobacillus crispatus Dominant Vaginal Microbiome Is Associated with Inhibitory Activity of Female Genital Tract Secretions against Escherichia coli

Objective Female genital tract secretions inhibit E. coli ex vivo and the activity may prevent colonization and provide a biomarker of a healthy microbiome. We hypothesized that high E. coli inhibitory activity would be associated with a Lactobacillus crispatus and/or jensenii dominant microbiome and differ from that of women with low inhibitory activity. Study Design Vaginal...

Characterization of SNPs Associated with Prostate Cancer in Men of Ashkenazic Descent from the Set of GWAS Identified SNPs: Impact of Cancer Family History and Cumulative SNP Risk Prediction

-Frederick, Inc. In addition, the authors note that Dr. Robert D. Burk is an Academic Editor of PLOS ONE. However, the authors declare that there is no conflict of interest and that this does not alter the

Evolution and Taxonomic Classification of Alphapapillomavirus 7 Complete Genomes: HPV18, HPV39, HPV45, HPV59, HPV68 and HPV70

BackgroundThe species Alphapapillomavirus 7 (alpha-7) contains human papillomavirus genotypes that account for 15% of invasive cervical cancers and are disproportionately associated with adenocarcinoma of the cervix. Complete genome analyses enable identification and nomenclature of variant lineages and sublineages. MethodsThe URR/E6 region was sequenced to screen for novel...

Longitudinal Analysis of Carcinogenic Human Papillomavirus Infection and Associated Cytologic Abnormalities in the Guanacaste Natural History Study: Looking Ahead to Cotesting

Background. Few studies have addressed the timing of cervical cytologic abnormalities and human papillomavirus (HPV) positivity during the course of an infection. It remains largely unknown how infections detected by HPV and cytology wax and wane relative to each other. The aim of this analysis was to assess the longitudinal relationship of abnormal cytology and HPV positivity in...

Clustering of Multiple Human Papillomavirus Infections in Women From a Population-Based Study in Guanacaste, Costa Rica

Objective. To evaluate clustering patterns of prevalent infection with multiple human papillomavirus (HPV) types in 8365 nonhysterectomized women from the Guanacaste Study of HPV Natural History. Methods. HPV testing was performed on cervical cells by MY09/M11 L1 degenerate consensus primer polymerase chain reaction method, with dot-blot hybridization for genotyping. Logistic...

Degradation of p53 by Human Alphapapillomavirus E6 Proteins Shows a Stronger Correlation with Phylogeny than Oncogenicity

Background Human Papillomavirus (HPV) E6 induced p53 degradation is thought to be an essential activity by which high-risk human Alphapapillomaviruses (alpha-HPVs) contribute to cervical cancer development. However, most of our understanding is derived from the comparison of HPV16 and HPV11. These two viruses are relatively distinct viruses, making the extrapolation of these...

Methylation of Human Papillomavirus Type 16 Genome and Risk of Cervical Precancer in a Costa Rican Population

Robert D. Burk ) 0 1 0 Executive Blvd, EPS/7101 , Rockville, MD 20892 ( 1 Affiliations of authors: Division of Cancer Epidemiology and Genetics, Department of Health and Human Services, National Cancer

The Cervical Microbiome over 7 Years and a Comparison of Methodologies for Its Characterization

Background The rapidly expanding field of microbiome studies offers investigators a large choice of methods for each step in the process of determining the microorganisms in a sample. The human cervicovaginal microbiome affects female reproductive health, susceptibility to and natural history of many sexually transmitted infections, including human papillomavirus (HPV). At...

Methylation of HPV18, HPV31, and HPV45 Genomes and Cervical Intraepithelial Neoplasia Grade 3

Background Persistent infections with carcinogenic human papillomavirus (HPV) types are the necessary cause of cervical cancer. We recently demonstrated that the HPV16 genome is strongly methylated in cervical precancer compared with transient infections. However, the extent of methylation in other HPV types and its role in progression to cancer is poorly understood.

A population-based cross-sectional study of age-specific risk factors for high risk human papillomavirus prevalence in rural Nigeria

Kayode O Ajenifuja Nicolas A Wentzensen 0 Akinfolarin C Adepiti Sholom Wacholder 0 Robert D Burk Mark Schiffman 0 0 Division of Cancer Epidemiology and Genetics, National Cancer Institute, National

Long-Term Persistence of Prevalently Detected Human Papillomavirus Infections in the Absence of Detectable Cervical Precancer and Cancer

Background. Detailed descriptions of long-term persistence of human papillomavirus (HPV) in the absence of cervical precancer are lacking. Methods. In a large, population-based natural study conducted in Guanacaste, Costa Rica, we studied a subset of 810 initially HPV-positive women with ≥3 years of active follow-up with ≥3 screening visits who had no future evidence of cervical...

The Oral Cavity Contains Abundant Known and Novel Human Papillomaviruses From the Betapapillomavirus and Gammapapillomavirus Genera

Background. Human papillomaviruses (HPVs) primarily sort into 3 genera: Alphapapillomavirus (α-HPV), predominantly isolated from mucosa, and Betapapillomavirus (β-HPV) and Gammapapillomavirus (γ-HPV), predominantly isolated from skin. HPV types might infect body sites that are different from those from which they were originally isolated. Methods. We investigated the spectrum of...

Sequence Imputation of HPV16 Genomes for Genetic Association Studies

Background Human Papillomavirus type 16 (HPV16) causes over half of all cervical cancer and some HPV16 variants are more oncogenic than others. The genetic basis for the extraordinary oncogenic properties of HPV16 compared to other HPVs is unknown. In addition, we neither know which nucleotides vary across and within HPV types and lineages, nor which of the single nucleotide...

Evolution and Taxonomic Classification of Human Papillomavirus 16 (HPV16)-Related Variant Genomes: HPV31, HPV33, HPV35, HPV52, HPV58 and HPV67

Background Human papillomavirus 16 (HPV16) species group (alpha-9) of the Alphapapillomavirus genus contains HPV16, HPV31, HPV33, HPV35, HPV52, HPV58 and HPV67. These HPVs account for 75% of invasive cervical cancers worldwide. Viral variants of these HPVs differ in evolutionary history and pathogenicity. Moreover, a comprehensive nomenclature system for HPV variants is lacking...

A comparison of clinically utilized human papillomavirus detection methods in head and neck cancer

13 Gerard J Nuovo 4 6 8 10 11 12 13 Maomi Li 5 6 8 10 11 12 13 Anne Dunne 6 7 8 10 11 12 13 Nicole Kawachi 6 8 9 10 11 12 13 Richard V Smith 6 8 9 10 11 3 12 13 Robert D Burk 1 6 7 8 10 11 12 13