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Risk factors for herpes simplex virus type-1 infection and reactivation: Cross-sectional studies among EPIC-Norfolk participants

Waterboer, Robert Luben, Nicholas J. Wareham, Charlotte Warren-Gash. Formal analysis: Harriet Forbes. Funding acquisition: Nicholas J. Wareham, Charlotte Warren-Gash. Investigation: Harriet Forbes ... , Charlotte Warren-Gash. Methodology: Harriet Forbes, Ben Warne, Lars Doelken, Nicole Brenner, Tim Waterboer, Robert Luben, Nicholas J. Wareham, Charlotte Warren-Gash, Effrossyni Gkrania-Klotsas. Project

Alcohol consumption and future hospital usage: The EPIC-Norfolk prospective population study

women aged 40±79 years 1993±1997. (PDF) Acknowledgments The authors thank the participants, general practitioners, and staff of EPIC-Norfolk. Author Contributions Conceptualization: Robert Luben ... , Shabina Hayat, Angela Mulligan, Marleen Lentjes, Nicholas Wareham, Kay-Tee Khaw. Data curation: Robert Luben. Formal analysis: Robert Luben, Kay-Tee Khaw. Funding acquisition: Nicholas Wareham, Kay-Tee

Understanding the relationship between cognition and death: a within cohort examination of cognitive measures and mortality

Despite several studies demonstrating an independent and inverse association between cognition and mortality, the nature of this association still remains unclear. To examine the association of cognition and mortality after accounting for sociodemographic, health and lifestyle factors and to explore both test and population characteristics influencing this relationship. In a...

Evaluation at scale of microbiome-derived metabolites as biomarker of flavan-3-ol intake in epidemiological studies

. Ensunsa Abigail Britten Debora Lucarelli Robert Luben Philip B. Grace Deborah H. Mawson Amy Tym Antonia Wierzbicki Kay-Tee Khaw Hagen Schroeter Gunter G. C. Kuhnle OPEN Published: xx xx xxxx The accurate

Polyclonal human antibodies against glycans bearing red meat-derived non-human sialic acid N-glycolylneuraminic acid are stable, reproducible, complex and vary between individuals: Total antibody levels are associated with colorectal cancer risk

, Walter Willett, Ajit Varki. Data curation: Annie N. Samraj, Kimberly A. Bertrand, Robert Luben, Zahra Khedri, Dzung Nguyen, Christopher J. Gregg, Sandra L. Diaz, Sherilyn Sawyer, Heather Eliassen, Vered ... Padler-Karavani, Kana Wu, Kay-Tee Khaw, Walter Willett. 22 / 27 Formal analysis: Annie N. Samraj, Kimberly A. Bertrand, Robert Luben, Dzung Nguyen, Heather Eliassen, Vered Padler-Karavani, Kana Wu

Fracture Risk in Relation to Serum 25-Hydroxyvitamin D and Physical Activity: Results from the EPIC-Norfolk Cohort Study

replication analysis. Researchers wishing to request data can contact the Head of Informatics ±Robert Luben, at Department of Public Health and Primary Care, Strangeways Research Laboratory, Wort's Causeway

Fatigue is associated with excess mortality in the general population: results from the EPIC-Norfolk study

Background Significant fatigue is a frequent reason for seeking medical advice in the general population. Patients, however, commonly feel their complaint is ignored. This situation may be because clinicians perceive fatigue to be benign, unrelated to traditional biomedical outcomes such as premature mortality. The present study aimed to investigate whether an association between...

Cross Sectional Associations between Socio-Demographic Factors and Cognitive Performance in an Older British Population: The European Investigation of Cancer in Norfolk (EPIC-Norfolk) Study

Laboratory, Wort's Causeway, Cambridge, UK. Email: , or contact the Head of Informatics at EPIC-Norfolk, Robert Luben E mail: . Funding: The infrastructure for this study was supported by the Medical Research

Distribution of lipid parameters according to different socio-economic indicators- the EPIC-Norfolk prospective population study

Shamarina Shohaimi 0 Matthijs S Boekholdt Robert Luben Nick J Wareham Kay-Tee Khaw 0 Department of Biology, Faculty of Science, Universiti Putra Malaysia , Serdang, Selangor 43400 , Malaysia

Body Mass Index, Smoking, and Alcohol and Risks of Barrett’s Esophagus and Esophageal Adenocarcinoma: A UK Prospective Cohort Study

Background The timing of the risk factors cigarette smoking, alcohol and obesity in the development of Barrett’s esophagus (BE) and esophageal adenocarcinoma (EAC) is unclear. Aims To investigate these exposures in the aetiology of BE and EAC in the same population. Methods The cohort included 24,068 men and women, aged 39–79 years, recruited between 1993 and 1997 into the...

Cognitive function in a general population of men and women: a cross sectional study in the European Investigation of Cancer–Norfolk cohort (EPIC-Norfolk)

Background Although ageing is strongly associated with cognitive decline, a wide range of cognitive ability is observed in older populations with varying rates of change across different cognitive domains. Methods Cognitive function was measured as part of the third health examination of the European Prospective Investigation of Cancer in Norfolk (EPIC-Norfolk 3) between 2006 and...

Cognitive function in a general population of men and women: a cross sectional study in the European Investigation of Cancer–Norfolk cohort (EPIC-Norfolk)

Although ageing is strongly associated with cognitive decline, a wide range of cognitive ability is observed in older populations with varying rates of change across different cognitive domains. Cognitive function was measured as part of the third health examination of the European Prospective Investigation of Cancer in Norfolk (EPIC-Norfolk 3) between 2006 and 2011 (including...

Plasma Phospholipid Fatty Acid Concentration and Incident Coronary Heart Disease in Men and Women: The EPIC-Norfolk Prospective Study

Luben 0 Nicholas Wareham 0 Martijn B. Katan, Vrije Universiteit Amsterdam, Netherlands 0 1 Department of Public Health and Primary Care, University of Cambridge School of Clinical Medicine, Cambridge

Daytime Napping and the Risk of All-Cause and Cause-Specific Mortality: A 13-Year Follow-up of a British Population

, Shabina Hayat, Robert Luben, Carol Brayne, Kay-Tee Khaw); and Division of Mental Health & Wellbeing, Warwick Medical School, University of Warwick, Coventry, UK (Francesco P. Cappuccio). The design and

Seropositivity and Higher Immunoglobulin G Antibody Levels Against Cytomegalovirus Are Associated With Mortality in the Population-Based European Prospective Investigation of Cancer–Norfolk Cohort

Background. The relationship between cytomegalovirus (CMV) infection and mortality among immunocompetent individuals is uncertain. We aimed to examine whether seropositivity for CMV and the level of CMV immunoglobulin G (IgG) antibody are associated with all-cause and cause-specific mortality. Methods. We used data from a random sample of 13 090 participants aged 40–79 years at...

Cross Sectional and Longitudinal Associations between Cardiovascular Risk Factors and Age Related Macular Degeneration in the EPIC-Norfolk Eye Study

Purpose To examine the cross sectional and longitudinal relationship between cardiovascular risk factors and age-related macular degeneration (AMD) in a large British cohort study. Methods The EPIC Norfolk Eye study is nested in a larger prospective cohort study. Data on cardiovascular risk factors were collected at baseline (1993-1997) and follow up (2006-2011) via clinical...

The physical capability of community-based men and women from a British cohort: the European Prospective Investigation into Cancer (EPIC)-Norfolk study

Background The European Working Group for Sarcopenia in Older People (EWGSOP) published a case-finding algorithm for sarcopenia, recommending muscle mass measurement in older adults with low grip strength (women <20 kg; men <30 kg) or slow walking speed (≤0.8 m/s). However, the implications of adopting this algorithm into clinical practice are unclear. Therefore, we aimed to...

Higher Immunoglobulin G Antibody Levels Against Cytomegalovirus Are Associated With Incident Ischemic Heart Disease in the Population-Based EPIC-Norfolk Cohort

Background. Cytomegalovirus (CMV) is associated with ischemic heart disease (IHD) among organ transplant recipients. The relationship between the levels of antibody for CMV with IHD in immunocompetent individuals is uncertain. Methods. We measured baseline CMV immunoglobulin G (IgG) levels in 12 574 participants without IHD from the population-based EPIC-Norfolk cohort, aged 40...

Self-Rated Health and Cardiovascular Disease Incidence: Results from a Longitudinal Population-Based Cohort in Norfolk, UK

Introduction Self-rated health (SRH) predicts chronic disease morbidity including cardiovascular disease (CVD). In a population-based cohort, we examined the association between SRH and incident CVD and whether this association was independent of socio-demographic, clinical and behavioural participant characteristics. Methods Population-based prospective cohort study (European...

Exposure to Ambient Air Pollution and the Risk of Inflammatory Bowel Disease: A European Nested Case–Control Study

Background Industrialization has been linked to the etiology of inflammatory bowel disease (IBD). Aim We investigated the association between air pollution exposure and IBD. Methods The European Prospective Investigation into Cancer and Nutrition cohort was used to identify cases with Crohn’s disease (CD) (n = 38) and ulcerative colitis (UC) (n = 104) and controls (n = 568) from...