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23 papers found.
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CMR feature tracking in cardiac asymptomatic systemic sclerosis: Clinical implications

: Konstantinos Bratis, H?kan Arheden, Genovefa Kolovou, Sophie Mavrogeni, Ellen Ostenfeld. Data curation: Roger Hesselstrand, Georgia Karabela, Efthymios Stavropoulos, Gikas Katsifis, George D. Kitas, Petros P

Respiratory symptoms are poor predictors of concomitant chronic obstructive pulmonary disease in patients with primary Sjögren’s syndrome

Involvement of the respiratory system, in particular dry airways and chronic obstructive pulmonary disease (COPD), is common in patients with primary Sjögren’s syndrome (pSS). As respiratory symptoms are also common in pSS patients and may have different etiologies, we wanted to evaluate the amount and impact of respiratory symptoms in out-patients with pSS and to assess if such...

Analysis of complement biomarkers in systemic sclerosis indicates a distinct pattern in scleroderma renal crisis

Saxne 4 Anna M. Blom 0 3 Roger Hesselstrand 4 0 Department of Translational Medicine, Section of Medical Protein Chemistry, Lund University , Inga Marie Nilssons Street 53, Malmö S-20502 , Sweden 1

High frequency ultrasound of skin involvement in systemic sclerosis – a follow-up study

Introduction High-frequency ultrasound offers a potential for objective and quantitative assessment of skin thickness and skin echogenicity in systemic sclerosis (SSc). Few studies have however assessed the longitudinal changes of skin involvement using ultrasound. The aim of the study was to investigate changes in skin thickness in early SSc using high frequency ultrasound...

Faecal levels of calprotectin in systemic sclerosis are stable over time and are higher compared to primary Sjögren’s syndrome and rheumatoid arthritis

Introduction Faecal calprotectin (FC) has been proposed to be a biomarker of gastrointestinal (GI) disease in systemic sclerosis (SSc). The purpose of this study was to extend cross-sectional observations and prospectively assess the variability of FC over time in SSc patients. We also aimed to examine FC in relation to immunosuppressive therapy. Finally we wanted to analyse FC...

Pulmonary blood volume indexed to lung volume is reduced in newly diagnosed systemic sclerosis compared to normals – a prospective clinical cardiovascular magnetic resonance study addressing pulmonary vascular changes

Background Pulmonary involvement, manifested as pulmonary arterial hypertension or pulmonary fibrosis, is the most common cause of death in systemic sclerosis (SSc). We aimed to explore the feasibility of detecting early pulmonary involvement in SSc using recently developed non-invasive quantitative measures of pulmonary physiology using cardiovascular magnetic resonance (CMR...

Cartilage oligomeric matrix protein-induced complement activation in systemic sclerosis

Introduction Complexes between cartilage oligomeric matrix protein (COMP) and the complement activation product C3b have been found in the circulation of patients with rheumatoid arthritis and systemic lupus erythematosus. In systemic sclerosis (SSc) COMP expression in the skin is upregulated both in lesional and non-lesional skin, which is also reflected in an increased amount...

Extracellular matrix alterations and acute inflammation; developing in parallel during early induction of pulmonary fibrosis

Rydell-Törmänen, Kristofer Andréasson, Roger Hesselstrand, Dick Heinegård & Tore SaxneSection of LungBiology, Department of Experimental Medical Science, Lund University, Lund, SwedenKristina Rydell ... journals • PubMed • Google ScholarSearch for Kristofer Andréasson in:Nature Research journals • PubMed • Google ScholarSearch for Roger Hesselstrand in:Nature Research journals • PubMed • Google

Serum COMP-C3b complexes in rheumatic diseases and relation to anti-TNF-α treatment

Introduction Cartilage oligomeric matrix protein (COMP) is found at elevated concentrations in sera of patients with joint diseases such as rheumatoid arthritis (RA) and osteoarthritis (OA). We recently showed that COMP activates complement via the alternative pathway and that COMP-C3b complexes are present in sera of RA patients, but not in healthy controls. We now set out to...

The Pronounced Th17 Profile in Systemic Sclerosis (SSc) Together with Intracellular Expression of TGFβ and IFNγ Distinguishes SSc Phenotypes

Background Systemic sclerosis (SSc) is an autoimmune disease where controversy on Th1/Th2 balance dominates. We investigated whether the recently discovered Th17 pattern was present in SSc. Methodology and Principal Findings Patients were subdivided as having limited cutaneous SSc (lcSSc, n = 12) or diffuse cutaneous SSc (dcSSc, n = 24). A further arbitrary subdivision was made...

KCNA5 gene is not confirmed as a systemic sclerosis-related pulmonary arterial hypertension genetic susceptibility factor

Mara Teresa Camps Carlos Tolosa Esther Vicente-Rabaneda Mara Victoria Egurbide for the Spanish Scleroderma Group Annemie J Schuerwegh Roger Hesselstrand Claudio Lunardi Jacob M van Laar Paul Shiels

A multicenter study confirms CD226 gene association with systemic sclerosis-related pulmonary fibrosis

Introduction CD226 genetic variants have been associated with a number of autoimmune diseases and recently with systemic sclerosis (SSc). The aim of this study was to test the influence of CD226 loci in SSc susceptibility, clinical phenotypes and autoantibody status in a large multicenter European population. Methods A total of seven European populations of Caucasian ancestry...