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T cell receptor repertoire among women who cleared and failed to clear cervical human papillomavirus infection: An exploratory proof-of-principle study

Kuhs, Shih-Wen Lin, Xing Hua, Mark Schiffman, Robert D. Burk, Ana Cecilia Rodriguez, Rolando Herrero, Christian C. Abnet, Neal D. Freedman, Ligia A. Pinto, David Hamm, Harlan Robins, Allan Hildesheim ... , Jianxin Shi, Mahboobeh Data curation: Xing Hua, Mark Schiffman, Ana Cecilia Rodriguez, Rolando Herrero, David Formal analysis: Xing Hua, David Hamm, Jianxin Shi. Funding acquisition: Mahboobeh Safaeian

Prevalence of and Associated Risk Factors for High Risk Human Papillomavirus among Sexually Active Women, Swaziland

Background High risk human papillomavirus (hr-HPV) infection and the dual burden of HIV remains a huge challenge in some low-income countries (LICs) such as Swaziland with limited or no data. We estimated the prevalence and investigated determinants of hr-HPV, including HIV infection among sexually active women in Swaziland. Methods A total of 655 women aged between 15 and 49...

Human Papillomavirus (HPV) Vaccines: Limited Cross-Protection against Additional HPV Types

Rolando Herrero Proyecto Epidemiolgico Guanacaste Fundacin INCIENSA San Jose Costa Rica - Approximately 15 different human papillomavirus (HPV) types from 5 species (A5, A6, A7, A9, and A11) may ... , analysis, and interpretation of the data and are not funded by vaccine manufacturing companies. Financial support: none reported. Reprints or correspondence: Dr. Rolando Herrero, PO Box 1256151 Santa Ana

An Updated Natural History Model of Cervical Cancer: Derivation of Model Parameters

Genetics, National Cancer Institute, Bethesda, Maryland (Mark Schiffman, Alan Hildesheim); Proyecto Epidemiológica Guanacaste, Fundación INCIENSA, San José, Costa Rica (Ana Cecilia Rodriguez, Rolando Herrero ... ); and Prevention and Implementation Group, International Agency for Research on Cancer, Lyon, France (Rolando Herrero). This work was supported by the National Cancer Institute (grant U54CA164336) and in

Genetic Variants in Nicotine Addiction and Alcohol Metabolism Genes, Oral Cancer Risk and the Propensity to Smoke and Drink Alcohol: A Replication Study in India

Background Genetic variants in nicotinic acetylcholine receptor and alcohol metabolism genes have been associated with propensity to smoke tobacco and drink alcohol, respectively, and also implicated in genetic susceptibility to head and neck cancer. In addition to smoking and alcohol, tobacco chewing is an important oral cancer risk factor in India. It is not known if these...

Performance of Self-Collected Cervical Samples in Screening for Future Precancer Using Human Papillomavirus DNA Testing

instructed participants on how to cist), Paula González (coinvestigator), Diego Guillén (pathologist), collect the self-sample at the clinics. Rolando Herrero (co-principal investigator), Silvia E.  Jiménez

Impact of Human Papillomavirus Vaccination on Cervical Cytology Screening, Colposcopy, and Treatment

(Instituto Costarricense de Investigación y Enseñanza en Nutrición y Salud) Foundation, San José, Costa Rica (Ana Cecilia Rodríguez, Rolando Herrero, Paula González, Carolina Porras, Silvia Jiménez); Division ... , International Agency for Research on Cancer, Lyon, France (Rolando Herrero, Paula González). The Costa Rica Vaccine Trial was part of a longstanding collaboration between investigators in Costa Rica and the US

Human Papillomavirus Vaccine Should Be Given before Sexual Debut for Maximum Benefit

Allan Hildesheim 1 Rolando Herrero 0 0 Proyecto Epidemiologico Guanacaste , Fundacion INCIENSA, San Jose , Costa Rica 1 Division of Cancer Epidemiology and Genetics, National Cancer Institute

Evolution and Taxonomic Classification of Alphapapillomavirus 7 Complete Genomes: HPV18, HPV39, HPV45, HPV59, HPV68 and HPV70

BackgroundThe species Alphapapillomavirus 7 (alpha-7) contains human papillomavirus genotypes that account for 15% of invasive cervical cancers and are disproportionately associated with adenocarcinoma of the cervix. Complete genome analyses enable identification and nomenclature of variant lineages and sublineages. MethodsThe URR/E6 region was sequenced to screen for novel...

A large, population-based study of age-related associations between vaginal pH and human papillomavirus infection

Background Vaginal pH is related to genital tract inflammation and changes in the bacterial flora, both suggested cofactors for persistence of human papillomavirus (HPV) infection. To evaluate the relationship between vaginal pH and HPV, we analyzed data from our large population-based study in Guanacaste, Costa Rica. We examined vaginal pH and the risk of HPV infection...

Longitudinal Analysis of Carcinogenic Human Papillomavirus Infection and Associated Cytologic Abnormalities in the Guanacaste Natural History Study: Looking Ahead to Cotesting

Background. Few studies have addressed the timing of cervical cytologic abnormalities and human papillomavirus (HPV) positivity during the course of an infection. It remains largely unknown how infections detected by HPV and cytology wax and wane relative to each other. The aim of this analysis was to assess the longitudinal relationship of abnormal cytology and HPV positivity in...

Clustering of Multiple Human Papillomavirus Infections in Women From a Population-Based Study in Guanacaste, Costa Rica

Objective. To evaluate clustering patterns of prevalent infection with multiple human papillomavirus (HPV) types in 8365 nonhysterectomized women from the Guanacaste Study of HPV Natural History. Methods. HPV testing was performed on cervical cells by MY09/M11 L1 degenerate consensus primer polymerase chain reaction method, with dot-blot hybridization for genotyping. Logistic...

Methylation of Human Papillomavirus Type 16 Genome and Risk of Cervical Precancer in a Costa Rican Population

Background Previous studies have suggested an association between human papillomavirus type 16 (HPV16) genome methylation and cervical intraepithelial neoplasia grade 3 (CIN3) (ie, cervical precancer) and cancer, but the results have been inconsistent.

The Cervical Microbiome over 7 Years and a Comparison of Methodologies for Its Characterization

Background The rapidly expanding field of microbiome studies offers investigators a large choice of methods for each step in the process of determining the microorganisms in a sample. The human cervicovaginal microbiome affects female reproductive health, susceptibility to and natural history of many sexually transmitted infections, including human papillomavirus (HPV). At...

Long-Term Persistence of Prevalently Detected Human Papillomavirus Infections in the Absence of Detectable Cervical Precancer and Cancer

Background. Detailed descriptions of long-term persistence of human papillomavirus (HPV) in the absence of cervical precancer are lacking. Methods. In a large, population-based natural study conducted in Guanacaste, Costa Rica, we studied a subset of 810 initially HPV-positive women with ≥3 years of active follow-up with ≥3 screening visits who had no future evidence of cervical...

The Oral Cavity Contains Abundant Known and Novel Human Papillomaviruses From the Betapapillomavirus and Gammapapillomavirus Genera

Background. Human papillomaviruses (HPVs) primarily sort into 3 genera: Alphapapillomavirus (α-HPV), predominantly isolated from mucosa, and Betapapillomavirus (β-HPV) and Gammapapillomavirus (γ-HPV), predominantly isolated from skin. HPV types might infect body sites that are different from those from which they were originally isolated. Methods. We investigated the spectrum of...

Sequence Imputation of HPV16 Genomes for Genetic Association Studies

Background Human Papillomavirus type 16 (HPV16) causes over half of all cervical cancer and some HPV16 variants are more oncogenic than others. The genetic basis for the extraordinary oncogenic properties of HPV16 compared to other HPVs is unknown. In addition, we neither know which nucleotides vary across and within HPV types and lineages, nor which of the single nucleotide...

Effect of Different Human Papillomavirus Serological and DNA Criteria on Vaccine Efficacy Estimates

Rodriguez, Paula Gonzalez, Rolando Herrero); Prevention and Implementation Group, International Agency for Research on Cancer, Lyon, France (Paula Gonzalez, Rolando Herrero); Public Health Foundation of India

Evolution and Taxonomic Classification of Human Papillomavirus 16 (HPV16)-Related Variant Genomes: HPV31, HPV33, HPV35, HPV52, HPV58 and HPV67

Background Human papillomavirus 16 (HPV16) species group (alpha-9) of the Alphapapillomavirus genus contains HPV16, HPV31, HPV33, HPV35, HPV52, HPV58 and HPV67. These HPVs account for 75% of invasive cervical cancers worldwide. Viral variants of these HPVs differ in evolutionary history and pathogenicity. Moreover, a comprehensive nomenclature system for HPV variants is lacking...