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Neuromuscular blocking agents in acute respiratory distress syndrome: a systematic review and meta-analysis of randomized controlled trials

Introduction Randomized trials investigating neuromuscular blocking agents in adult acute respiratory distress syndrome (ARDS) have been inconclusive about effects on mortality, which is very high in this population. Uncertainty also exists about the associated risk of ICU-acquired weakness. Methods We conducted a systematic review and meta-analysis. We searched the Cochrane...

Tips for Teachers of Evidence-Based Medicine: Understanding Odds Ratios and Their Relationship to Risk Ratios

INTRODUCTIONOdds ratios (OR) commonly appear in the medical literature summarizing the comparative effects of interventions and exposures in observational studies, randomized trials, and meta-analyses. Clinicians find it difficult to understand odds and odds ratios as measures of association, although they may be comfortable with the parallel concepts of risk and risk ratios...

Intra-abdominal hypertension and the abdominal compartment syndrome: updated consensus definitions and clinical practice guidelines from the World Society of the Abdominal Compartment Syndrome

Andrew W. Kirkpatrick Derek J. Roberts Jan De Waele Roman Jaeschke Manu L. N. G. Malbrain Bart De Keulenaer Juan Duchesne Martin Bjorck Ari Leppaniemi Janeth C. Ejike Michael Sugrue Michael Cheatham

Surviving Sepsis Campaign: International Guidelines for Management of Severe Sepsis and Septic Shock, 2012

S. Douglas Roman Jaeschke Tiffany M. Osborn Mark E. Nunnally Sean R. Townsend Konrad Reinhart Ruth M. Kleinpell Derek C. Angus Clifford S. Deutschman Flavia R. Machado Gordon D. Rubenfeld Steven Webb

Systems for grading the quality of evidence and the strength of recommendations II: Pilot study of a new system

Flottorp4, Gordon H Guyatt 11 Robin T Harbour 10 Suzanne Hill 9 Roman Jaeschke 14 Alessandro Liberati 13 Nicola Magrini 8 James Mason 5 Dianne O'Connell 3 Andrew D Oxman 12 Bob Phillips 4 Holger

Surviving Sepsis Campaign: International guidelines for management of severe sepsis and septic shock: 2008

Margaret M. Parker Roman Jaeschke Konrad Reinhart Derek C. Angus Christian Brun-Buisson Richard Beale Thierry Calandra Jean-Francois Dhainaut Herwig Gerlach Maurene Harvey John J. Marini John Marshall Marco

Surviving Sepsis Campaign: International guidelines for management of severe sepsis and septic shock: 2008

Objective To provide an update to the original Surviving Sepsis Campaign clinical management guidelines, “Surviving Sepsis Campaign guidelines for management of severe sepsis and septic shock,” published in 2004. Design Modified Delphi method with a consensus conference of 55 international experts, several subsequent meetings of subgroups and key individuals, teleconferences, and...